Hypothalamic inflammation: marker or mechanism of obesity pathogenesis? (Q37031049)

17 August 2017

4 references

19 March 2019

24 March 2019

12 September 2019

5 July 2021

Hypothalamic inflammation: marker or mechanism of obesity pathogenesis? (English)

1 reference

17 August 2017

0 references

0 references

3 references

19 March 2019

24 March 2019

12 September 2019

1 reference

12 September 2019

1 reference

5 July 2021

2

Stephan J Guyenet

1 reference

17 August 2017

Joshua P Thaler

1

1 reference

17 August 2017

Mauricio D Dorfman

series ordinal

3

1 reference

17 August 2017

Brent E Wisse

series ordinal

4

1 reference

17 August 2017

Michael W Schwartz

series ordinal

5

1 reference

17 August 2017

language of work or name

English

0 references

publication date

1 August 2013

5 references

17 August 2017

19 March 2019

24 March 2019

12 September 2019

5 July 2021

5 references

17 August 2017

19 March 2019

24 March 2019

12 September 2019

5 July 2021

62

1 reference

17 August 2017

2629-2634

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17 August 2017

8

1 reference

Creative Commons Attribution-NonCommercial-NoDerivatives

17 August 2017

4 references

19 March 2019

24 March 2019

12 September 2019

5 July 2021

on focus list of Wikimedia project

ScienceSource

0 references

cites work

Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes.

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Neuron-specific deletion of peroxisome proliferator-activated receptor delta (PPARδ) in mice leads to increased susceptibility to diet-induced obesity

29 September 2017

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Increased hypothalamic inflammation associated with the susceptibility to obesity in rats exposed to high-fat diet

29 September 2017

1 reference

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Alterations in mouse hypothalamic adipokine gene expression and leptin signaling following chronic spinal cord injury and with advanced age

29 September 2017

1 reference

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Leptin action through hypothalamic nitric oxide synthase-1-expressing neurons controls energy balance

29 September 2017

1 reference

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High-fat-diet exposure induces IgG accumulation in hypothalamic microglia

29 September 2017

1 reference

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Obesity is associated with hypothalamic injury in rodents and humans

29 September 2017

1 reference

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Neuroprotection by leptin in a rat model of permanent cerebral ischemia: effects on STAT3 phosphorylation in discrete cells of the brain.

29 September 2017

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Synaptic pruning by microglia is necessary for normal brain development

29 September 2017

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Inflammatory links between obesity and metabolic disease

29 September 2017

1 reference

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Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice

29 September 2017

1 reference

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Altered hypothalamic function in diet-induced obesity

29 September 2017

1 reference

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Leptin resistance and desensitization of hypophagia during prolonged inflammatory challenge

29 September 2017

1 reference

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Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress

29 September 2017

1 reference

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Low-grade hypothalamic inflammation leads to defective thermogenesis, insulin resistance, and impaired insulin secretion

29 September 2017

1 reference

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Inflammatory mechanisms in obesity

29 September 2017

1 reference

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AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Obesity-mediated inflammation may damage the brain circuit that regulates food intake

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Obesity and leptin resistance: distinguishing cause from effect

29 September 2017

1 reference

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Energy intake in weight-reduced humans

29 September 2017

1 reference

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Minireview: Inflammation and obesity pathogenesis: the hypothalamus heats up.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Changes in melanocortin expression and inflammatory pathways in fetal offspring of nonhuman primates fed a high-fat diet

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Uncoupling of inflammation and insulin resistance by NF-kappaB in transgenic mice through elevated energy expenditure

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Molecular dissection of reactive astrogliosis and glial scar formation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Receptors for tumor necrosis factor-alpha play a protective role against obesity and alter adipose tissue macrophage status

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

High-fat diet induces apoptosis of hypothalamic neurons

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Mutations in ligands and receptors of the leptin-melanocortin pathway that lead to obesity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Mechanisms of leptin action and leptin resistance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Activity-dependent regulation of energy metabolism by astrocytes: an update

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Increased hypothalamic protein tyrosine phosphatase 1B contributes to leptin resistance with age

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Microglia provide neuroprotection after ischemia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Physical activity and long-term maintenance of weight loss

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Astrocyte activation and reactive gliosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Obesity is associated with macrophage accumulation in adipose tissue

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Central nervous system control of food intake

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Role of the CNS melanocortin system in the response to overfeeding

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Obesity and diabetes in TNF-alpha receptor- deficient mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Responses of leptin to short-term fasting and refeeding in humans: a link with ketogenesis but not ketones themselves

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Diet, behavior modification, and exercise: a review of obesity treatments from a long-term perspective

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

The energy budget, thermogenic capacity and behavior in Swiss mice exposed to a consecutive decrease in temperatures

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Region-specific leptin resistance within the hypothalamus of diet-induced obese mice.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Effects of fasting and glucose infusion on basal and overnight leptin concentrations in normal-weight women.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Acute and long-term suppression of feeding behavior by POMC neurons in the brainstem and hypothalamus, respectively.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Nuclear factor κB (NF-κB) suppresses food intake and energy expenditure in mice by directly activating the Pomc promoter.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Exercise protects against high-fat diet-induced hypothalamic inflammation.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Transgenic mice with astrocyte-targeted production of interleukin-6 are resistant to high-fat diet-induced increases in body weight and body fat.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Endoplasmic reticulum stress plays a central role in development of leptin resistance

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Long-term persistence of adaptive thermogenesis in subjects who have maintained a reduced body weight.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Control of glutamate clearance and synaptic efficacy by glial coverage of neurons

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Experimental obesity in man.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Metabolic response to experimental overfeeding in lean and overweight healthy volunteers.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3717869

Decreased fat mass in interleukin-1 receptor antagonist-deficient mice: impact on adipogenesis, food intake, and energy expenditure

4 September 2018

1 reference

12 December 2020

Combined Interleukin-6 and Interleukin-1 Deficiency Causes Obesity in Young Mice

1 reference

12 December 2020

Mature-Onset Obesity in Interleukin-1 Receptor I Knockout Mice

1 reference

12 December 2020

Activation of Microglia in Specific Hypothalamic Nuclei and the Cerebellum of Adult Rats Exposed to Neonatal Overnutrition

1 reference

12 December 2020

Treatment of obesity by very low calorie diet, behavior therapy, and their combination: a five-year perspective

1 reference

12 December 2020

Lean-body-mass composition and resting energy expenditure before and after long-term overfeeding

1 reference

12 December 2020

Identifiers

DOI

10.2337/DB12-1605

1 reference

17 August 2017

1 reference

17 August 2017

1 reference