Mutations in ligands and receptors of the leptin-melanocortin pathway that lead to obesity (Q37263858)

19 August 2017

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title

Mutations in ligands and receptors of the leptin-melanocortin pathway that lead to obesity (English)

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19 August 2017

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Stephen O'Rahilly

2

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author name string

I Sadaf Farooqi

series ordinal

1

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19 August 2017

9 September 2008

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Nature Clinical Practice Endocrinology and Metabolism

19 August 2017

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19 August 2017

4

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19 August 2017

569-577

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19 August 2017

10

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Regulation of Fto/Ftm gene expression in mice and humans

19 August 2017

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

Genetics of body-weight regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Variation in FTO contributes to childhood obesity and severe adult obesity

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Obesity associated genetic variation in FTO is associated with diminished satiety

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Lack of Association of Fatness-Related FTO Gene Variants with Energy Expenditure or Physical Activity

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Common variants near MC4R are associated with fat mass, weight and risk of obesity

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Positional cloning of the mouse obese gene and its human homologue

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Role of leptin in the neuroendocrine response to fasting

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Mechanisms of leptin action and leptin resistance

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Central nervous system control of food intake

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Pro-opiomelanocortin processing in the hypothalamus: impact on melanocortin signalling and obesity

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Congenital leptin deficiency is associated with severe early-onset obesity in humans

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptin therapy

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

A leptin missense mutation associated with hypogonadism and morbid obesity.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Partial leptin deficiency and human adiposity.

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Soluble leptin receptor in serum of subjects with complete resistance to leptin: relation to fat mass.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Effects of recombinant leptin therapy in a child with congenital leptin deficiency.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Leptin regulates striatal regions and human eating behavior

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Protein tyrosine phosphatase 1B negatively regulates leptin signaling in a hypothalamic cell line

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

The Central Melanocortin System and Energy Homeostasis

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Proopiomelanocortin and energy balance: insights from human and murine genetics

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Obesity due to proopiomelanocortin deficiency: three new cases and treatment trials with thyroid hormone and ACTH4-10.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Heterozygosity for aPOMC-Null Mutation and Increased Obesity Risk in Humans

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Mutational analysis of the proopiomelanocortin gene in Caucasians with early onset obesity

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

A role for beta-melanocyte-stimulating hormone in human body-weight regulation

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Interactions of human melanocortin 4 receptor with nonpeptide and peptide agonists

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Prevalence and functionality of paucimorphic and privateMC4Rmutations in a large, unselected European British population, scanned by meltMADGE

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

The central melanocortin system directly controls peripheral lipid metabolism

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

BDNF regulates eating behavior and locomotor activity in mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

A de novo mutation affecting human TrkB associated with severe obesity and developmental delay

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Development of a pharmacologically improved peptide agonist of the leptin receptor

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

A novel and selective beta-melanocyte-stimulating hormone-derived peptide agonist for melanocortin 4 receptor potently decreased food intake and body weight gain in diet-induced obese rats.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Melanocortin-4 receptor agonists for the treatment of obesity

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https://api.crossref.org/works/10.1038%2FNCPENDMET0966

7 January 2021

Identifiers

DOI

10.1038/NCPENDMET0966

1 reference

19 August 2017

1 reference

PubMed ID

18779842