Lipid-based delivery systems and intestinal lymphatic drug transport: a mechanistic update (Q37043914)

17 August 2017

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title

Lipid-based delivery systems and intestinal lymphatic drug transport: a mechanistic update (English)

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17 August 2017

Natalie L Trevaskis

1

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17 August 2017

William N Charman

series ordinal

2

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17 August 2017

Christopher J H Porter

series ordinal

3

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17 August 2017

language of work or name

English

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publication date

7 November 2007

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Advanced Drug Delivery Reviews

17 August 2017

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17 August 2017

60

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17 August 2017

6

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17 August 2017

702-716

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Origin and characteristics of endogenous lipid in thoracic duct lymph in rat

17 August 2017

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12 December 2020

Dietary fat inhibits the intestinal metabolism of the carcinogen benzo[a]pyrene in fish

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12 December 2020

Synthesis and biological evaluation of two glycerolipidic prodrugs of didanosine for direct lymphatic delivery against HIV

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12 December 2020

Apolipoprotein B synthesis in rat small intestine: regulation by dietary triglyceride and biliary lipid.

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12 December 2020

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12 December 2020

Biosynthesis of triacylglycerols

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12 December 2020

Intestinal lipoprotein metabolism.

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12 December 2020

The effect of oils on the lymphatic absorption of DDT

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12 December 2020

VIP21/caveolin is a cholesterol-binding protein

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12 December 2020

Fatty acid-binding protein and its relation to fatty acid oxidation

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12 December 2020

Intestinal lipid absorption and transport

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12 December 2020

Membrane binding proteins are the major determinants for the hepatocellular transmembrane flux of long-chain fatty acids bound to albumin

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12 December 2020

Effect of different surfactants in biorelevant medium on the secretion of a lipophilic compound in lipoproteins using Caco-2 cell culture

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12 December 2020

Hepatitis B virus infection in lymphatic tissues in inactive hepatitis B carriers.

1 reference

12 December 2020

Intestinal lymphatic drug transport: an update

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12 December 2020

The origin of cholesterol in the mesenteric lymph of the rat

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12 December 2020

Factors influencing triacylglycerol delivery into mesenteric lymph

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12 December 2020

ESTIMATION AND SUBCELLULAR DISTRIBUTION OF LECITHINASE ACTIVITY IN RAT INTESTINAL MUCOSA

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12 December 2020

Sterol carrier protein-2: not just for cholesterol any more

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12 December 2020

1,3-dipalmitoylglycerol ester of chlorambucil as a lymphotropic, orally administrable antineoplastic agent

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12 December 2020

Uptake of lipophilic drugs by plasma derived isolated chylomicrons: linear correlation with intestinal lymphatic bioavailability

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12 December 2020

Biosynthesis of chylomicron triacylglycerols by rats fed glyceryl or alkyl esters of menhaden oil fatty acids

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12 December 2020

Evidence for separate pathways of chylomicron and very low-density lipoprotein assembly and transport by rat small intestine

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12 December 2020

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12 December 2020

Mechanisms of digestion and absorption of dietary vitamin A.

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12 December 2020

Partitioning of polar fatty acids into lymph and portal vein after intestinal absorption in the rat.

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12 December 2020

Cholesteryl ester absorption by small intestinal brush border membrane is protein-mediated

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12 December 2020

Contribution of lymphatically transported testosterone undecanoate to the systemic exposure of testosterone after oral administration of two andriol formulations in conscious lymph duct-cannulated dogs.

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12 December 2020

The portal transport of absorbed fatty acids

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12 December 2020

Incorporation of Dietary Lecithin and Lysolecithin into Lymph Chylomicrons in the Rat

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12 December 2020

Human ABC transporter ABCG2 in xenobiotic protection and redox biology

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12 December 2020

Postprandial chylomicron formation and fat absorption in multidrug resistance gene 2 P-glycoprotein-deficient mice.

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12 December 2020

Apparent convergence (at 2-monoacylglycerol level) of phosphatidic acid and 2-monoacylglycerol pathways of synthesis of chylomicron triacylglycerols

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12 December 2020

Lipid vehicles for intestinal lymphatic drug absorption

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12 December 2020

[Lymphatic delivery of drugs and its application to cancer chemotherapy (author's transl)]

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12 December 2020

An examination of the interplay between enterocyte-based metabolism and lymphatic drug transport in the rat.

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12 December 2020

Secretion of apolipoprotein B-containing lipoproteins from HeLa cells is dependent on expression of the microsomal triglyceride transfer protein and is regulated by lipid availability

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12 December 2020

New insights in the lymphatic spread of oesophageal cancer and its implications for the extent of surgical resection

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12 December 2020

The structure of lymphatic capillaries in lymph formation

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12 December 2020

Oral testosterone, a reappraisal

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12 December 2020

Comparative analyses of canine distemper viral isolates from clinical cases of canine distemper in vaccinated dogs

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12 December 2020

The role of the lymphatic transport in the enteral absorption of naftifine by the rat

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12 December 2020

Monoacylglycerol metabolism in human intestinal Caco-2 cells: evidence for metabolic compartmentation and hydrolysis

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12 December 2020

CD36 is a receptor for oxidized low density lipoprotein

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12 December 2020

Sterol carrier protein-2

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12 December 2020

Intestinal lymphatic absorption of cyclosporin A following oral administration in an olive oil solution in rats

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12 December 2020

Role of ABCG1 and other ABCG family members in lipid metabolism

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12 December 2020

Pentadecanoic acid-5-C14; its absorption and lymphatic transport

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12 December 2020

Lipid-based formulations for intestinal lymphatic delivery

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12 December 2020

Effect of Pluronic L81, a hydrophobic surfactant, on intestinal mucosal cholesterol homeostasis

1 reference

12 December 2020

Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system

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12 December 2020

Identification of a receptor mediating absorption of dietary cholesterol in the intestine

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12 December 2020

Reduced cholesterol transmucosal transport in rats with inhibited mucosal acyl CoA:cholesterol acyltransferase and normal pancreatic function

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12 December 2020

The entry of foreign compounds into the thoracic duct lymph of the rat.

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12 December 2020

Localization and regulation of the putative membrane fatty-acid transporter (FAT) in the small intestine. Comparison with fatty acid-binding proteins (FABP)

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12 December 2020

The lymph lipid precursor pool is a key determinant of intestinal lymphatic drug transport.

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12 December 2020

Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly

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12 December 2020

Intestinal absorption of lecithin and lysolecithin by lymph fistula rats

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12 December 2020

Different impacts of intestinal lymphatic transport on the oral bioavailability of structurally similar synthetic lipophilic cannabinoids: dexanabinol and PRS-211,220

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12 December 2020

Uptake and metabolism of circulating fatty acids by rat intestine

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12 December 2020

Nuclear receptors and lipid physiology: opening the X-files

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12 December 2020

Accelerated lipid absorption in mice overexpressing intestinal SR-BI.

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12 December 2020

Lipoproteins associated with the Golgi apparatus isolated from epithelial cells of rat small intestine

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12 December 2020

Bile increases intestinal lymphatic drug transport in the fasted rat.

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12 December 2020

Liver Fatty Acid-binding Protein Initiates Budding of Pre-chylomicron Transport Vesicles from Intestinal Endoplasmic Reticulum

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12 December 2020

Hydrocarbon transport in chylomicrons and high‐density lipoproteins in rat

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12 December 2020

Fatty acid binding protein in locust and mammalian muscle. Comparison of structure, function and regulation

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12 December 2020

Intestinal cholesterol transport proteins: an update and beyond

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12 December 2020

Effect of increasing lipid loads on the ability of the endoplasmic reticulum to transport lipid to the Golgi

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12 December 2020

Successful in silico predicting of intestinal lymphatic transfer

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12 December 2020

Uptake of fatty acids by jejunal mucosal cells is mediated by a fatty acid binding membrane protein

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12 December 2020

ABC transporters in lipid transport

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12 December 2020

The effects of pluronics block copolymers and Cremophor EL on intestinal lipoprotein processing and the potential link with P-glycoprotein in Caco-2 cells

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12 December 2020

Lymph flow pattern in the intact thoracic duct in sheep.

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12 December 2020

Isolation and characterization of a mucosal triacylglycerol pool undergoing hydrolysis

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12 December 2020

Lipid-based delivery systems for improving the bioavailability and lymphatic transport of a poorly water-soluble LTB4 inhibitor

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12 December 2020

Receptor (SLAM [CD150]) recognition and the V protein sustain swift lymphocyte-based invasion of mucosal tissue and lymphatic organs by a morbillivirus

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12 December 2020

Scavenger receptor class B type I is a multiligand HDL receptor that influences diverse physiologic systems

1 reference

12 December 2020

Stimulation of Triglyceride-Rich Lipoprotein Secretion by Polysorbate 80: In Vitro and in Vivo Correlation Using Caco-2 Cells and a Cannulated Rat Intestinal Lymphatic Model

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12 December 2020

Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption

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12 December 2020

Intestinal lymphatic transport of halofantrine occurs after oral administration of a unit-dose lipid-based formulation to fasted dogs

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12 December 2020

Role of lymphoid organs in the pathogenesis of human immunodeficiency virus (HIV) infection

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12 December 2020

Intracellular lipid binding proteins of the small intestine

1 reference

12 December 2020

Important effect of food on the bioavailability of oral testosterone undecanoate

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12 December 2020

Differences in the lipoprotein binding profile of halofantrine in fed and fasted human or beagle plasma are dictated by the respective masses of core apolar lipoprotein lipid.

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12 December 2020

Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs

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12 December 2020

Intestinal lipoprotein synthesis and secretion

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12 December 2020

Aminopeptidase N (CD13) is a molecular target of the cholesterol absorption inhibitor ezetimibe in the enterocyte brush border membrane

1 reference

12 December 2020

Phosphatidylcholine inhibits and lysophosphatidylcholine enhances the lymphatic absorption of alpha-tocopherol in adult rats

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12 December 2020

Intestinal lymph as pathway for transport of absorbed fatty acids of different chain lengths

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12 December 2020

Acyl-CoA oxidase activity and peroxisomal fatty acid oxidation in rat tissues.

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12 December 2020

A dual, concentration-dependent absorption mechanism of linoleic acid by rat jejunum in vitro

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12 December 2020

Role of pancreatic cholesterol esterase in the uptake and esterification of cholesterol by isolated intestinal cells

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12 December 2020

Portal transport of absorbed lipids in rats

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12 December 2020

Absorption of a pharmacological dose of vitamin D3 from two different lipid vehicles in man: comparison of peanut oil and a medium chain triglyceride

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12 December 2020

Animal models for the study of intestinal lymphatic drug transport

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12 December 2020

Portal transport of long acyl chain lipids: effect of phosphatidylcholine and low infusion rates

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12 December 2020

Uptake of micellar long-chain fatty acid and sn-2-monoacylglycerol into human intestinal Caco-2 cells exhibits characteristics of protein-mediated transport

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12 December 2020

Interactions between microsomal triglyceride transfer protein and apolipoprotein B within the endoplasmic reticulum in a heterologous expression system.

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12 December 2020

Fatty acid regulation of fatty acid-binding protein expression in the small intestine

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12 December 2020

Steady-state kinetic analysis of triacylglycerol delivery into mesenteric lymph

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12 December 2020

The lymphatic route. 1) Albumin and hyaluronidase modify the normal distribution of interferon in lymph and plasma

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12 December 2020

Long-chain fatty acid uptake into adipocytes depends on lipid raft function

1 reference

12 December 2020

Evaluation of a chylomicron flow blocking approach to investigate the intestinal lymphatic transport of lipophilic drugs

1 reference

12 December 2020

Drug-like properties and the causes of poor solubility and poor permeability

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12 December 2020

Effect of oily vehicles on absorption of mepitiostane by the lymphatic system in rats

1 reference

12 December 2020

The pharmacology and metabolism of testosterone undecanoate (TU), a new orally active androgen

1 reference

12 December 2020

Recombinant lipoproteins: implications for structure and assembly of native lipoproteins

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12 December 2020

Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters

1 reference

12 December 2020

Microsomal triglyceride transfer protein: a multifunctional protein

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12 December 2020

Common mechanisms of monoacylglycerol and fatty acid uptake by human intestinal Caco-2 cells

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12 December 2020

ROLE OF BILE AND PANCREATIC JUICE IN CHOLESTEROL ABSORPTION AND ESTERIFICATION

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12 December 2020

Electron microscopic study of intestinal fat absorption in vitro from mixed micelles containing linolenic acid, monoolein, and bile salt

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12 December 2020

Formation and transport of chylomicrons by enterocytes to the lymphatics

1 reference

12 December 2020

Comparison of total oral bioavailability and the lymphatic transport of halofantrine from three different unsaturated triglycerides in lymph-cannulated conscious rats

1 reference

12 December 2020

The metastatic cascade in prostate cancer

1 reference

12 December 2020

Effect of short-, medium-, and long-chain fatty acid-based vehicles on the absolute oral bioavailability and intestinal lymphatic transport of halofantrine and assessment of mass balance in lymph-cannulated and non-cannulated rats

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12 December 2020

Effect of bile on absorption of mepitiostane by the lymphatic system in rats

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12 December 2020

Role of the intestine in chylomicron remnant clearance

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12 December 2020

Chylomicron assembly and catabolism: role of apolipoproteins and receptors.

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12 December 2020

The PPARs: from orphan receptors to drug discovery

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12 December 2020

Uptake of long-chain fatty acids in HepG2 cells involves caveolae: analysis of a novel pathway.

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12 December 2020

Intestinal triacylglycerol storage pool size changes under differing physiological conditions

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12 December 2020

Differential involvement of peroxisome-proliferator-activated receptors alpha and delta in fibrate and fatty-acid-mediated inductions of the gene encoding liver fatty-acid-binding protein in the liver and the small intestine

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12 December 2020

Dietary saturated fatty acid content affects lymph lipoproteins: studies in the rat

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12 December 2020

Bioavailability of oral testosterone in males

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12 December 2020

Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers

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12 December 2020

The importance of the lysophosphatidylcholine and choline moiety of bile phosphatidylcholine in lymphatic transport of fat

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12 December 2020

Caco-2 cells as a model for intestinal lipoprotein synthesis and secretion.

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12 December 2020

A comparison of absorption of glycerol tristearate and glycerol trioleate by rat small intestine

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12 December 2020

Intestinal absorption of polyunsaturated phosphatidylcholine in the rat

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12 December 2020

A re-examination of the fate of glyceride-glycerol in neutral lipid absorption and transport

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12 December 2020

Very low density lipoproteins in intestinal lymph: origin, composition, and role in lipid transport in the fasting state

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12 December 2020

Electron microscopic studies of the assembly, intracellular transport, and secretion of chylomicrons by rat intestine

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12 December 2020

Physiochemical and physiological mechanisms for the effects of food on drug absorption: the role of lipids and pH.

1 reference

12 December 2020

Protein-mediated transfer of fluorescent-labeled phospholipids across brush border of rabbit intestine

1 reference

12 December 2020

The effect of different oils on the absorption of probucol in the rat

1 reference

12 December 2020

The interaction of lipophilic drugs with intestinal fatty acid-binding protein.

1 reference

12 December 2020

Transport of proteins across the endoplasmic reticulum membrane

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12 December 2020

An examination of the factors affecting intestinal lymphatic transport of dietary lipids

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12 December 2020

The role of the lymphatic system in subcutaneous absorption of macromolecules in the rat model

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12 December 2020

Role of Biliary Lecithin in Lymphatic Transport of Fat

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12 December 2020

Factors regulating the formation of chylomicrons and very-low-density lipoproteins by the rat small intestine.

1 reference

12 December 2020

Pharmacokinetics of recombinant human leukemia inhibitory factor in sheep.

1 reference

12 December 2020

Portal venous transport of long-chain fatty acids absorbed from rat intestine.

1 reference

12 December 2020

The cellular fatty acid binding proteins: aspects of structure, regulation, and function

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12 December 2020

An Acute and Coincident Increase in FABP Expression and Lymphatic Lipid and Drug Transport Occurs During Intestinal Infusion of Lipid-Based Drug Formulations to Rats

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12 December 2020

Biopharmaceutical challenges associated with drugs with low aqueous solubility--the potential impact of lipid-based formulations.

1 reference

12 December 2020

Scavenger receptor class B, type I-mediated uptake of various lipids into cells. Influence of the nature of the donor particle interaction with the receptor

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12 December 2020

New insights into the fatty acid-binding protein (FABP) family in the small intestine

1 reference

12 December 2020

Intestinal triglycerides are derived from both endogenous and exogenous sources

1 reference

12 December 2020

Contribution of lymphatic transport to the systemic exposure of orally administered moxidectin in conscious lymph duct-cannulated dogs

1 reference

12 December 2020

Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis

1 reference

12 December 2020

Prechylomicron transport vesicle: isolation and partial characterization

1 reference

12 December 2020

The role of lymphoid organs in the immunopathogenesis of HIV infection.

1 reference

12 December 2020

A proposed model for the assembly of chylomicrons

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12 December 2020

Examination of the role of intestinal fatty acid-binding protein in drug absorption using a parallel artificial membrane permeability assay.

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12 December 2020

Differences in the Intestinal Absorption of Saturated and Unsaturated Long Chain Fatty Acids

1 reference

12 December 2020

CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism

1 reference

12 December 2020

Coassimilation of dietary fat and benzo(a)pyrene in the small intestine: an absorption model using the killifish.

1 reference

12 December 2020

Interaction of severe acute respiratory syndrome-associated coronavirus with dendritic cells

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12 December 2020

Evidence for vesicles that mediate long-chain fatty acid uptake by human microvascular endothelial cells.

1 reference

12 December 2020

The Metabolic Fate of Lysolecithin Administered into Rat Duodenal Lumen

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12 December 2020

Triglyceride biosynthesis in the intestinal mucosa

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12 December 2020

A new concept of cellular uptake and intracellular trafficking of long-chain fatty acids

1 reference

12 December 2020

Influence of dietary fat saturation on lipid absorption in the rat

1 reference

12 December 2020

A conscious dog model for assessing the absorption, enterocyte-based metabolism, and intestinal lymphatic transport of halofantrine.

1 reference

12 December 2020

Mechanism of the intestinal absorption of drugs from oil-in-water emulsions. VII. Role of bile in the lymphatic transport of lipid-soluble compounds from triolein emulsions

1 reference

12 December 2020

Intracellular movement of triacylglycerols in the intestine.

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12 December 2020

10.1016/J.ADDR.2007.09.007

Identifiers

DOI

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17 August 2017

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