AZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics (Q37053876)

17 August 2017

AZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics (English)

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17 August 2017

Susanna Eketjäll

1

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17 August 2017

Juliette Janson

2

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17 August 2017

Karin Kaspersson

3

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17 August 2017

Anna Bogstedt

4

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17 August 2017

Fredrik Jeppsson

5

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17 August 2017

Johanna Fälting

6

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17 August 2017

Samantha Budd Haeberlein

7

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17 August 2017

Alan R Kugler

8

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17 August 2017

Robert C Alexander

9

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17 August 2017

Gvido Cebers

10

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17 August 2017

3 February 2016

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Journal of Alzheimer's Disease

17 August 2017

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17 August 2017

50

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17 August 2017

4

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17 August 2017

1109-1123

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Creative Commons Attribution-NonCommercial 4.0 International

17 August 2017

start time

22 February 2016

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Prediction and modeling of effects on the QTc interval for clinical safety margin assessment, based on single-ascending-dose study data with AZD3839.

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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27 June 2018

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27 June 2018

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27 June 2018

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Alzheimer's disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy

4 September 2018

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4 September 2018

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4 September 2018

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First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates

4 September 2018

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Extensions to the visual predictive check to facilitate model performance evaluation

4 September 2018

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Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice

4 September 2018

1 reference

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Macrocyclic inhibitors of beta-secretase: functional activity in an animal model

4 September 2018

1 reference

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Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4927864

Evidence that A beta 42 is the real culprit in Alzheimer's disease.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4927864

Species independence in brain tissue binding using brain homogenates

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4927864

20 October 2018

Identifiers

DOI

10.3233/JAD-150834

1 reference

17 August 2017

1 reference

17 August 2017

PubMed publication ID

26890753

1 reference