AZ-4217: a high potency BACE inhibitor displaying acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice. (Q42710724)

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scientific article published on June 2013

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English	AZ-4217: a high potency BACE inhibitor displaying acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice.	scientific article published on June 2013

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scholarly article

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3 March 2020

AZ-4217: a high potency BACE inhibitor displaying acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice (English)

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3 March 2020

author name string

Susanna Eketjäll

1

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3 March 2020

Juliette Janson

2

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3 March 2020

Fredrik Jeppsson

3

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3 March 2020

Alexander Svanhagen

4

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3 March 2020

Karin Kolmodin

5

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3 March 2020

Susanne Gustavsson

6

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3 March 2020

Ann-Cathrin Radesäter

7

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3 March 2020

Kristina Eliason

8

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3 March 2020

Sveinn Briem

9

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3 March 2020

Paulina Appelkvist

10

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3 March 2020

Camilla Niva

11

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3 March 2020

Anna-Lena Berg

12

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3 March 2020

Sofia Karlström

13

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3 March 2020

Britt-Marie Swahn

14

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3 March 2020

Johanna Fälting

15

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3 March 2020

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publication date

1 June 2013

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3 March 2020

Journal of Neuroscience

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3 March 2020

33

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3 March 2020

24

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3 March 2020

10075-10084

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3 March 2020

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of amyloid beta peptides from brain extracts of transgenic mice overexpressing the London mutant of human amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of peripheral nerve myelination by the beta-secretase BACE1

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macrocyclic inhibitors of beta-secretase: functional activity in an animal model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bace1 modulates myelination in the central and peripheral nervous system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of a high-throughput brain slice method for studying drug distribution in the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-beta in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design and synthesis of aminohydantoins as potent and selective human β-secretase (BACE1) inhibitors with enhanced brain permeability

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased clearance of CNS beta-amyloid in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced sodium channel Na(v)1.1 levels in BACE1-null mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Species independence in brain tissue binding using brain homogenates

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The precision of axon targeting of mouse olfactory sensory neurons requires the BACE1 protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Advances in the identification of γ-secretase inhibitors for the treatment of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small-molecule BACE1 inhibitors: a patent literature review (2006 - 2011).

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

γ-Secretase modulator in Alzheimer's disease: shifting the end.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design and synthesis of β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors with in vivo brain reduction of β-amyloid peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure- and property-based design of aminooxazoline xanthenes as selective, orally efficacious, and CNS penetrable BACE inhibitors for the treatment of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of four basic models of indirect pharmacodynamic responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitation of amyloid beta-protein (A beta) in the cortex during aging and in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23761903

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.1165-13.2013

1 reference

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3 March 2020

1 reference

Europe PubMed Central

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3 March 2020

1 reference

Europe PubMed Central

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3 March 2020

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