Intraspinal AAV Injections Immediately Rostral to a Thoracic Spinal Cord Injury Site Efficiently Transduces Neurons in Spinal Cord and Brain. (Q37065567)

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scientific article published on 23 July 2013

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English	Intraspinal AAV Injections Immediately Rostral to a Thoracic Spinal Cord Injury Site Efficiently Transduces Neurons in Spinal Cord and Brain.	scientific article published on 23 July 2013

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scholarly article

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5 March 2020

Intraspinal AAV Injections Immediately Rostral to a Thoracic Spinal Cord Injury Site Efficiently Transduces Neurons in Spinal Cord and Brain (English)

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5 March 2020

Michelle C Klaw

1

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author name string

Chen Xu

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23 July 2013

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Molecular Therapy. Nucleic acids

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e108

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5 March 2020

Intramuscular scAAV9-SMN injection mediates widespread gene delivery to the spinal cord and decreases disease severity in SMA mice.

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29 September 2017

Rho signaling and axon regeneration

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29 September 2017

Molecular control of axon growth: insights from comparative gene profiling and high-throughput screening

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Exogenous BDNF enhances the integration of chronically injured axons that regenerate through a peripheral nerve grafted into a chondroitinase-treated spinal cord injury site

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Viral vectors and delivery strategies for CNS gene therapy

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Krüppel-like Factor 7 engineered for transcriptional activation promotes axon regeneration in the adult corticospinal tract

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The assessment of adeno-associated vectors as potential intrinsic treatments for brainstem axon regeneration

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Neuronal intrinsic mechanisms of axon regeneration.

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Intramuscular AAV delivery of NT-3 alters synaptic transmission to motoneurons in adult rats

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PTEN deletion enhances the regenerative ability of adult corticospinal neurons

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Neuronal intrinsic barriers for axon regeneration in the adult CNS.

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Timing of decompressive surgery of spinal cord after traumatic spinal cord injury: an evidence-based examination of pre-clinical and clinical studies

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29 September 2017

Combining peripheral nerve grafts and chondroitinase promotes functional axonal regeneration in the chronically injured spinal cord.

1 reference

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29 September 2017

KLF family members regulate intrinsic axon regeneration ability.

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Efficient retrograde transport of adeno-associated virus type 8 to spinal cord and dorsal root ganglion after vector delivery in muscle

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Efficient gene therapy-based method for the delivery of therapeutics to primate cortex

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Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway

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29 September 2017

Intraspinal microinjection of chondroitinase ABC following injury promotes axonal regeneration out of a peripheral nerve graft bridge

1 reference

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Adeno-associated virus serotypes: vector toolkit for human gene therapy

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Intramuscular injection of AAV-GDNF results in sustained expression of transgenic GDNF, and its delivery to spinal motoneurons by retrograde transport

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A new millenium for spinal cord regeneration: growth-associated genes

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Recombinant adeno-associated virus type 2, 4, and 5 vectors: transduction of variant cell types and regions in the mammalian central nervous system.

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Interactions of colchicine with tubulin

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High content screening of cortical neurons identifies novel regulators of axon growth

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Axonal transport of adeno-associated viral vectors is serotype-dependent

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Combining peripheral nerve grafting and matrix modulation to repair the injured rat spinal cord

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27 June 2018

Naturally occurring singleton residues in AAV capsid impact vector performance and illustrate structural constraints.

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Oligodendrocyte-specific gene expression in mouse brain: use of a myelin-forming cell type-specific promoter in an adeno-associated virus

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Differences in horseradish peroxidase labeling of sensory, motor and sympathetic neurons following chronic axotomy of the rat sural nerve.

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Neutralization of inhibitory molecule NG2 improves synaptic transmission, retrograde transport, and locomotor function after spinal cord injury in adult rats.

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Local and retrograde gene transfer into primate neuronal pathways via adeno-associated virus serotype 8 and 9.

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Cell survival or cell death: differential vulnerability of long descending and thoracic propriospinal neurons to low thoracic axotomy in the adult rat.

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Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6.

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Muscle injection of AAV-NT3 promotes anatomical reorganization of CST axons and improves behavioral outcome following SCI.

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Adeno-associated virus-mediated L1 expression promotes functional recovery after spinal cord injury.

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4 September 2018

Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system

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Adeno-associated viral vector-mediated gene transfer of brain-derived neurotrophic factor reverses atrophy of rubrospinal neurons following both acute and chronic spinal cord injury.

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The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats

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Control of membrane sealing in injured mammalian spinal cord axons.

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4 September 2018

Combining an autologous peripheral nervous system "bridge" and matrix modification by chondroitinase allows robust, functional regeneration beyond a hemisection lesion of the adult rat spinal cord

1 reference

https://pubmed.ncbi.nlm.nih.gov/23881451

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficient retrograde neuronal transduction utilizing self-complementary AAV1

1 reference

https://pubmed.ncbi.nlm.nih.gov/23881451

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraneural colchicine inhibition of adenoviral and adeno-associated viral vector remote spinal cord gene delivery

1 reference

https://pubmed.ncbi.nlm.nih.gov/23881451

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adeno-associated viral vector gene expression in the adult rat spinal cord following remote vector delivery

1 reference

https://pubmed.ncbi.nlm.nih.gov/23881451

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adeno-Associated Virus (AAV) Vectors in the CNS

1 reference

https://pubmed.ncbi.nlm.nih.gov/23881451

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/MTNA.2013.34

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5 March 2020

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5 March 2020

1 reference

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5 March 2020

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