Long-chain carboxychromanols, metabolites of vitamin E, are potent inhibitors of cyclooxygenases (Q37068624)

18 August 2017

Long-chain carboxychromanols, metabolites of vitamin E, are potent inhibitors of cyclooxygenases (English)

1 reference

18 August 2017

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Helene Freiser

5

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author name string

Qing Jiang

1

1 reference

18 August 2017

Xinmin Yin

2

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18 August 2017

Markus A Lill

3

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18 August 2017

Matthew L Danielson

4

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18 August 2017

Jianjie Huang

6

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18 August 2017

language of work or name

English

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publication date

11 December 2008

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Proceedings of the National Academy of Sciences of the United States of America

18 August 2017

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18 August 2017

105

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18 August 2017

51

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18 August 2017

20464-20469

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Gamma-tocopherol supplementation alone and in combination with alpha-tocopherol alters biomarkers of oxidative stress and inflammation in subjects with metabolic syndrome.

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Ozone enhancement of lower airway allergic inflammation is prevented by gamma-tocopherol

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Anti-inflammatory properties of alpha- and gamma-tocopherol

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Identification and quantitation of novel vitamin E metabolites, sulfated long-chain carboxychromanols, in human A549 cells and in rats

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Influence of major structural features of tocopherols and tocotrienols on their omega-oxidation by tocopherol-omega-hydroxylase

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Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities

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Vitamin E, oxidative stress, and inflammation

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1 reference

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Long-chain carboxychromanols are the major metabolites of tocopherols and tocotrienols in A549 lung epithelial cells but not HepG2 cells.

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1 reference

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gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis

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The role of vitamin E in atherosclerosis

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Mechanism of free radical oxygenation of polyunsaturated fatty acids by cyclooxygenases

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Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2.

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Cyclooxygenase enzymes: catalysis and inhibition

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1 reference

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gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention

29 September 2017

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gamma-tocopherol and its major metabolite, in contrast to alpha-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells

29 September 2017

1 reference

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1 reference

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Vitamin E: function and metabolism

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1 reference

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Cyclooxygenase in biology and disease

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1 reference

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Cyclooxygenases 1 and 2

1 reference

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Sodium salicylate inhibits cyclo-oxygenase-2 activity independently of transcription factor (nuclear factor kappaB) activation: role of arachidonic acid

29 September 2017

1 reference

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Involvement of arginine 120, glutamate 524, and tyrosine 355 in the binding of arachidonate and 2-phenylpropionic acid inhibitors to the cyclooxygenase active site of ovine prostaglandin endoperoxide H synthase-1.

29 September 2017

1 reference

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Gamma-tocopherol supplementation inhibits protein nitration and ascorbate oxidation in rats with inflammation

29 September 2017

1 reference

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Mechanism of action of antiinflammatory drugs

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1 reference

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Empirical scoring functions: I. The development of a fast empirical scoring function to estimate the binding affinity of ligands in receptor complexes.

27 June 2018

1 reference

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Vitamin E in the prevention of prostate cancer: where are we today?

27 June 2018

1 reference

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Anti-inflammatory effects of tocopherol metabolites

4 September 2018

1 reference

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Alpha and gamma tocopherol metabolism in healthy subjects and patients with end-stage renal disease

4 September 2018

1 reference

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γ‐Tocopherol, but not α‐tocopherol, decreases proinflammatory eicosanoids and inflammation damage in rats

4 September 2018

1 reference

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Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes.

4 September 2018

1 reference

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gamma-tocopherol, but not alpha-tocopherol, potently inhibits neointimal formation induced by vascular injury in insulin resistant rats

4 September 2018

1 reference

12 December 2020

Mixed tocopherols inhibit azoxymethane-induced aberrant crypt foci in rats

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12 December 2020

Cytochrome P4503A-dependent metabolism of tocopherols and inhibition by sesamin

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12 December 2020

Purification of PGH synthase from sheep vesicular glands

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Arginine 120 of prostaglandin G/H synthase-1 is required for the inhibition by nonsteroidal anti-inflammatory drugs containing a carboxylic acid moiety

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0810962106

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18 August 2017

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1 reference

18 August 2017

PubMed publication ID

19074288

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