Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1 (Q37068663)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23842089%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

title

Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1 (English)

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4 March 2020

1

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author name string

Haruhiro Toko

2

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4 March 2020

Shirin Doroudgar

3

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4 March 2020

Shabana Din

4

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4 March 2020

Pearl Quijada

5

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4 March 2020

Anya Y Joyo

6

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4 March 2020

Luis Ornelas

7

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4 March 2020

Eri Joyo

8

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4 March 2020

Donna J Thuerauf

9

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4 March 2020

Mathias H Konstandin

10

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4 March 2020

Natalie Gude

11

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4 March 2020

Christopher C Glembotski

12

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4 March 2020

Mark A Sussman

13

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language of work or name

English

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publication date

10 July 2013

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Proceedings of the National Academy of Sciences of the United States of America

4 March 2020

published in

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4 March 2020

volume

110

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4 March 2020

issue

31

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4 March 2020

page(s)

12661-12666

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Preservation of myocardial structure is enhanced by pim-1 engineering of bone marrow cells

4 March 2020

cites work

1 reference

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mTOR signaling in growth control and disease

29 September 2017

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Role of PRAS40 in Akt and mTOR signaling in health and disease.

29 September 2017

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Orai1 deficiency leads to heart failure and skeletal myopathy in zebrafish

29 September 2017

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SUMO1-dependent modulation of SERCA2a in heart failure

29 September 2017

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In search of new therapeutic targets and strategies for heart failure: recent advances in basic science

29 September 2017

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AAV vectors for cardiac gene transfer: experimental tools and clinical opportunities

29 September 2017

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Nucleolar stress is an early response to myocardial damage involving nucleolar proteins nucleostemin and nucleophosmin

29 September 2017

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Cardiac progenitor cell commitment is inhibited by nuclear Akt expression

29 September 2017

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Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation.

29 September 2017

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mTOR: from growth signal integration to cancer, diabetes and ageing

29 September 2017

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The inotropic peptide βARKct improves βAR responsiveness in normal and failing cardiomyocytes through G(βγ)-mediated L-type calcium current disinhibition.

29 September 2017

1 reference

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Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

29 September 2017

1 reference

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Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies

29 September 2017

1 reference

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Reducing the risk of left ventricular hypertrophy in kidney transplant recipients: the potential role of mammalian target of rapamycin

29 September 2017

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Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID Trial), a first-in-human phase 1/2 clinical trial.

29 September 2017

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Pim-1 kinase antagonizes aspects of myocardial hypertrophy and compensation to pathological pressure overload

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732982

The binding of PRAS40 to 14-3-3 proteins is not required for activation of mTORC1 signalling by phorbol esters/ERK.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732982

Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface

29 September 2017

1 reference

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PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732982

The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1

29 September 2017

1 reference

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PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732982

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

29 September 2017

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Restoration of mechanical and energetic function in failing aortic-banded rat hearts by gene transfer of calcium cycling proteins

29 September 2017

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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732982

Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats

29 September 2017

1 reference

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Large-scale characterization of HeLa cell nuclear phosphoproteins

29 September 2017

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Hypertrophy of the heart: a new therapeutic target?

29 September 2017

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Phosphoinositide 3-kinase(p110α) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy

29 September 2017

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Identification of a proline-rich Akt substrate as a 14-3-3 binding partner

29 September 2017

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Erythropoietin activates mitochondrial biogenesis and couples red cell mass to mitochondrial mass in the heart

29 September 2017

1 reference

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Beneficial effects of Mammalian target of rapamycin inhibition on left ventricular remodeling after myocardial infarction

27 June 2018

1 reference

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Pim-1 regulates cardiomyocyte survival downstream of Akt.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732982

Adeno-associated virus-mediated expression of thyroid hormone receptor isoforms-alpha1 and -beta1 improves contractile function in pressure overload-induced cardiac hypertrophy

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732982

Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3732982

Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress.

4 September 2018

1 reference

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4 September 2018

Identifiers

DOI

10.1073/PNAS.1301455110

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23842089%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

0 references

1 reference

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4 March 2020

PubMed publication ID

23842089

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23842089%20AND%20SRC:MED&resulttype=core&format=json