The polyol pathway as a mechanism for diabetic retinopathy: attractive, elusive, and resilient (Q37068700)

18 August 2017

8 references

13 March 2019

14 March 2019

24 March 2019

25 April 2019

17 June 2019

7 November 2019

18 November 2019

19 July 2022

The polyol pathway as a mechanism for diabetic retinopathy: attractive, elusive, and resilient (English)

1 reference

18 August 2017

7 references

13 March 2019

14 March 2019

24 March 2019

25 April 2019

17 June 2019

7 November 2019

18 November 2019

1 reference

7 November 2019

1 reference

18 November 2019

Mara Lorenzi

1

1 reference

PMCID

1950230

18 August 2017

language of work or name

1 reference

1 January 2007

1 reference

Experimental Diabetes Research

18 August 2017

9 references

18 August 2017

13 March 2019

14 March 2019

24 March 2019

25 April 2019

17 June 2019

7 November 2019

18 November 2019

19 July 2022

2007

1 reference

18 August 2017

61038

1 reference

Creative Commons Attribution 3.0 Unported

18 August 2017

8 references

13 March 2019

14 March 2019

24 March 2019

25 April 2019

17 June 2019

7 November 2019

18 November 2019

on focus list of Wikimedia project

19 July 2022

copyright status

copyrighted

0 references

ScienceSource

0 references

cites work

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A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners

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Human aldose reductase expression accelerates diabetic atherosclerosis in transgenic mice

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Aldose reductase in diabetic microvascular complications

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Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications

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Surgical and other treatments of diabetic macular edema: an update

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Polymorphisms of the aldose reductase gene and susceptibility to diabetic microvascular complications

29 September 2017

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Vascular NAD(P)H oxidases: specific features, expression, and regulation

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Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy

29 September 2017

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Polyol pathway and diabetic peripheral neuropathy

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Effect of intensive therapy on the microvascular complications of type 1 diabetes mellitus

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Early cellular and molecular changes induced by diabetes in the retina

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Pharmacological inhibition of diabetic retinopathy: aminoguanidine and aspirin

29 September 2017

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A mouse model of galactose-induced cataracts

29 September 2017

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Aldose reductase-deficient mice develop nephrogenic diabetes insipidus

29 September 2017

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Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin

29 September 2017

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Glia cells of the monkey retina--II. Müller cells

29 September 2017

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Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy

29 September 2017

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Identity of a major 3-deoxyglucosone-reducing enzyme with aldehyde reductase in rat liver established by amino acid sequencing and cDNA expression

29 September 2017

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Hyperglycemic pseudohypoxia and diabetic complications.

29 September 2017

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The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group

29 September 2017

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Aldose reductase catalysis and crystallography. Insights from recent advances in enzyme structure and function

29 September 2017

1 reference

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An (A-C)n dinucleotide repeat polymorphic marker at the 5' end of the aldose reductase gene is associated with early-onset diabetic retinopathy in NIDDM patients

29 September 2017

1 reference

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Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens

29 September 2017

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Mechanism of human aldehyde reductase: characterization of the active site pocket

29 September 2017

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The sorbitol pathway and the complications of diabetes

29 September 2017

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Aldose reductase expression in human diabetic retina and retinal pigment epithelium

29 September 2017

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Pathogenesis of diabetic retinopathy

29 September 2017

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Identification of fructose 3-phosphate in the lens of diabetic rats

29 September 2017

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Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy

29 September 2017

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Developmental and physiological regulation of aldose reductase mRNA expression in renal medulla

29 September 2017

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GLUT1 glucose transporter expression in the diabetic and nondiabetic human eye.

29 September 2017

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Localization of aldose reductase in the human eye.

27 June 2018

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Aldose reductase in the BB rat: isolation, immunological identification and localization in the retina and peripheral nerve

27 June 2018

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Prevention of hemodynamic and vascular albumin filtration changes in diabetic rats by aldose reductase inhibitors.

27 June 2018

1 reference

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Prevention of retinal vessel changes associated with diabetic retinopathy in galactose-fed dogs by aldose reductase inhibitors

27 June 2018

1 reference

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27 June 2018

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Dissociation between biochemical and functional effects of the aldose reductase inhibitor, ponalrestat, on peripheral nerve in diabetic rats

27 June 2018

1 reference

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IGF-I specifically enhances axon outgrowth of corticospinal motor neurons.

27 June 2018

1 reference

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A selective aldose reductase inhibitor of a new structural class prevents or reverses early retinal abnormalities in experimental diabetic retinopathy.

4 September 2018

1 reference

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Long-term effects of ranirestat (AS-3201) on peripheral nerve function in patients with diabetic sensorimotor polyneuropathy

4 September 2018

1 reference

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Vascular damage in a mouse model of diabetic retinopathy: relation to neuronal and glial changes.

4 September 2018

1 reference

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Aldose reductase deficiency prevents diabetes-induced blood-retinal barrier breakdown, apoptosis, and glial reactivation in the retina of db/db mice.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950230

The Ins2Akita mouse as a model of early retinal complications in diabetes

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950230

Expression of acute-phase response proteins in retinal Müller cells in diabetes

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950230

Poly(ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950230

Aldose reductase inhibition by AS-3201 in sural nerve from patients with diabetic sensorimotor polyneuropathy

4 September 2018

1 reference

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Studies of rat and human retinas predict a role for the polyol pathway in human diabetic retinopathy

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950230

Exogenous surfactant replacement in ARDS--one day, someday, or never?

4 September 2018

1 reference

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Death of retinal neurons in streptozotocin-induced diabetic mice

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950230

Long-term treatment with fidarestat suppresses the development of diabetic retinopathy in STZ-induced diabetic rats

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950230

Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950230

A role for the polyol pathway in the early neuroretinal apoptosis and glial changes induced by diabetes in the rat.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950230

Early complement activation and decreased levels of glycosylphosphatidylinositol-anchored complement inhibitors in human and experimental diabetic retinopathy

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950230

The AGE inhibitor pyridoxamine inhibits development of retinopathy in experimental diabetes.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950230

Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled double-blind parallel group study

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950230

The role of Müller cells in the formation of the blood-retinal barrier.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1950230

Retinal capillaries: basement membrane thickening by galactosemia prevented with aldose reductase inhibitor

4 September 2018

1 reference

12 December 2020

Experimental Galactosemia Produces Diabetic-like Retinopathy

1 reference

12 December 2020

The effect of oxidation on sorbitol pathway kinetics

1 reference

12 December 2020

31P NMR studies of the diabetic lens

1 reference

12 December 2020

The absence of cataracts in mice with congenital hyperglycemia

1 reference

12 December 2020

Immunohistochemical localization of aldose reductase. II. Rat eye and kidney

1 reference

12 December 2020

Distribution of aldose reductase in ocular tissues

1 reference

12 December 2020

Increased renal aldose reductase activity, immunoreactivity, and mRNA in streptozocin-induced diabetic rats

1 reference

12 December 2020

Effect of aldose reductase inhibition and insulin treatment on retinal capillary basement membrane thickening in BB rats

1 reference

12 December 2020

A randomized trial of sorbinil, an aldose reductase inhibitor, in diabetic retinopathy. Sorbinil Retinopathy Trial Research Group

1 reference

12 December 2020

Glucose modulation of aldose reductase mRNA expression and its activity in cultured calf pulmonary artery endothelial cells

1 reference

12 December 2020

Aldose reductase inhibition fails to prevent retinopathy in diabetic and galactosemic dogs

1 reference

12 December 2020

Human kidney aldose and aldehyde reductases

1 reference

12 December 2020

Dose-dependent reduction of retinal vessel changes associated with diabetic retinopathy in galactose-fed dogs by the aldose reductase inhibitor M79175

1 reference

12 December 2020

Müller cell changes in human diabetic retinopathy

1 reference

12 December 2020

Glial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy. Penn State Retina Research Group

1 reference

12 December 2020

Z-2 microsatellite allele is linked to increased expression of the aldose reductase gene in diabetic nephropathy

1 reference

12 December 2020

A novel polymorphism in the aldose reductase gene promoter region is strongly associated with diabetic retinopathy in adolescents with type 1 diabetes

1 reference

12 December 2020

Response of capillary cell death to aminoguanidine predicts the development of retinopathy: comparison of diabetes and galactosemia

1 reference

12 December 2020

Identifiers

DOI

10.1155/2007/61038

1 reference

18 August 2017

1 reference

18 August 2017

1 reference

PMCID

1950230