Mechanisms of disease: sodium channels and neuroprotection in multiple sclerosis-current status (Q37070221)

18 August 2017

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title

Mechanisms of disease: sodium channels and neuroprotection in multiple sclerosis-current status (English)

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18 August 2017

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Stephen G Waxman

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18 August 2017

29 January 2008

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Nature Clinical Practice Neurology

18 August 2017

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18 August 2017

4

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18 August 2017

3

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18 August 2017

159-169

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Lidocaine unmasks silent demyelinative lesions in multiple sclerosis

18 August 2017

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0735

Protective effects of antiarrhythmic agents against anoxic injury in CNS white matter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0735

Preferential loss of myelin-associated glycoprotein reflects hypoxia-like white matter damage in stroke and inflammatory brain diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0735

Expression of the voltage-gated sodium channel NaV1.5 in the macrophage late endosome regulates endosomal acidification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0735

Treatment of paroxysmal disorders in multiple sclerosis with carbamazepine (Tegretol)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Trigeminal neuralgia in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Positive symptoms in multiple sclerosis: their treatment with sodium channel blockers, lidocaine and mexiletine.

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https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Slow sodium-dependent potential oscillations contribute to ectopic firing in mammalian demyelinated axons.

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https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Impulse conduction in multiple sclerosis: a theoretical basis for modification by temperature and pharmacological agents

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https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Antiepileptic medications in multiple sclerosis: adverse effects in a three-year follow-up study

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https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na(+)-Ca2+ exchanger.

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https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Calmodulin binds to the C terminus of sodium channels Nav1.4 and Nav1.6 and differentially modulates their functional properties.

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https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Na+-dependent sources of intra-axonal Ca2+ release in rat optic nerve during in vitro chemical ischemia.

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https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Calpain-dependent neurofilament breakdown in anoxic and ischemic rat central axons.

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https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Molecular changes in neurons in multiple sclerosis: altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na+/Ca2+ exchanger

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https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Remyelination in multiple sclerosis

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https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Remyelination is extensive in a subset of multiple sclerosis patients.

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https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Axonal protection in multiple sclerosis--a particular need during remyelination?

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https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Tertiary and quaternary local anesthetics protect CNS white matter from anoxic injury at concentrations that do not block excitability.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Correlation between electrophysiological effects of mexiletine and ischemic protection in central nervous system white matter.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Electrically active axons degenerate when exposed to nitric oxide

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https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

The role of nitric oxide in multiple sclerosis

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https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Nitric oxide-mediated mitochondrial damage in the brain: mechanisms and implications for neurodegenerative diseases.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Inhibition of brain macrophage/microglial respiratory chain enzyme activity in experimental autoimmune encephalomyelitis of the Lewis rat

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https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Blockers of sodium and calcium entry protect axons from nitric oxide-mediated degeneration

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https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Nitric oxide toxicity in CNS white matter: an in vitro study using rat optic nerve

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Co-localization of sodium channel Nav1.6 and the sodium-calcium exchanger at sites of axonal injury in the spinal cord in EAE.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Axonal damage in acute multiple sclerosis lesions.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Axonal transection in the lesions of multiple sclerosis

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https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Evidence for widespread axonal damage at the earliest clinical stage of multiple sclerosis.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Persistent functional deficit in multiple sclerosis and autosomal dominant cerebellar ataxia is associated with axon loss

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Spinal cord atrophy and disability in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis. Results of a longitudinal magnetic resonance spectroscopy study.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Neurological disability correlates with spinal cord axonal loss and reduced N-acetyl aspartate in chronic multiple sclerosis patients

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Hypoxia-like tissue injury as a component of multiple sclerosis lesions

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Axonal degeneration in multiple sclerosis: is it time for neuroprotective strategies?

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Neuroprotection of axons with phenytoin in experimental allergic encephalomyelitis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Phenytoin protects spinal cord axons and preserves axonal conduction and neurological function in a model of neuroinflammation in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Axonal protection using flecainide in experimental autoimmune encephalomyelitis.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Axonal protection achieved in a model of multiple sclerosis using lamotrigine

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Sodium channels contribute to microglia/macrophage activation and function in EAE and MS.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Neuroprotection in multiple sclerosis: therapeutic strategies and clinical trial design

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Exacerbation of experimental autoimmune encephalomyelitis after withdrawal of phenytoin and carbamazepine

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https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

T-lymphocyte invasiveness: control by voltage-gated Na+ channel activity.

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https://api.crossref.org/works/10.1038%2FNCPNEURO0735

7 January 2021

Identifiers

DOI

10.1038/NCPNEURO0735

1 reference

18 August 2017

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PubMed ID

18227822