Application of metabonomics in drug development (Q37074082)

18 August 2017

1 reference

title

Application of metabonomics in drug development (English)

1 reference

18 August 2017

Hector C Keun

1

1 reference

PubMed ID

18240906

18 August 2017

Toby J Athersuch

series ordinal

2

1 reference

18 August 2017

1 July 2007

1 reference

18 August 2017

1 reference

18 August 2017

8

1 reference

18 August 2017

7

1 reference

18 August 2017

731-741

1 reference

'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data

18 August 2017

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Metabolomics – the link between genotypes and phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Metabolic profiling of genetic disorders: a multitissue (1)H nuclear magnetic resonance spectroscopic and pattern recognition study into dystrophic tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Metabonomics in toxicology: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Metabonomic modeling of drug toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Choline phospholipid metabolism in cancer: consequences for molecular pharmaceutical interventions.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Therapeutic targets and biomarkers identified in cancer choline phospholipid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Tumour metabolomics in animal models of human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Real-time changes in 1H and 31P NMR spectra of malignant human mammary epithelial cells during treatment with the anti-inflammatory agent indomethacin.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Phospholipid metabolism and resistance to glucocorticoid-induced apoptosis in a human leukemic cell line: a 31P-NMR study using a phosphonium analog of choline

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

High-resolution (1)H NMR and magic angle spinning NMR spectroscopic investigation of the biochemical effects of 2-bromoethanamine in intact renal and hepatic tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

The Consortium for Metabonomic Toxicology (COMET): aims, activities and achievements

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Application of metabonomics in a compound ranking study in early drug development revealing drug-induced excretion of choline into urine.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Pharmaco-metabonomic phenotyping and personalized drug treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Metabolic profiling of CSF: evidence that early intervention may impact on disease progression and outcome in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Metabonomic identification of two distinct phenotypes in Sprague-Dawley (Crl:CD(SD)) rats

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Urine profiling using capillary electrophoresis-mass spectrometry and multivariate data analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Urinary electrophoretic profiles from chronic fatigue syndrome and chronic fatigue syndrome/fibromyalgia patients: a pilot study for achieving their normalization

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Increasing conclusiveness of metabonomic studies by chem-informatic preprocessing of capillary electrophoretic data on urinary nucleoside profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Metabolic fingerprinting in disease diagnosis: biomedical applications of infrared and Raman spectroscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

New modes of data partitioning based on PARS peak alignment for improved multivariate biomarker/biopattern detection in (1)H-NMR spectroscopic metabolic profiling of urine.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Scaling and normalization effects in NMR spectroscopic metabonomic data sets

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Negative impact of noise on the principal component analysis of NMR data

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Statistical total correlation spectroscopy: an exploratory approach for latent biomarker identification from metabolic 1H NMR data sets

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Statistical heterospectroscopy, an approach to the integrated analysis of NMR and UPLC-MS data sets: application in metabonomic toxicology studies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Statistically integrated metabonomic-proteomic studies on a human prostate cancer xenograft model in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Correlation of Ki-67 and gelsolin expression to clinical outcome in renal clear cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Cell motility as a prognostic factor in Stage I nonsmall cell lung carcinoma: the role of gelsolin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Prognostic significance of gelsolin expression level and variability in non-small cell lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Correlation between protein and mRNA abundance in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Analytical reproducibility in (1)H NMR-based metabonomic urinalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Understanding 'Global' Systems Biology: Metabonomics and the Continuum of Metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Summary recommendations for standardization and reporting of metabolic analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Detection ofin vivo biomarkers of phospholipidosis using NMR-based metabonomic approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Nuclear Magnetic Resonance Spectroscopic and Principal Components Analysis Investigations into Biochemical Effects of Three Model Hepatotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Susceptibility of Human Metabolic Phenotypes to Dietary Modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Improved analysis of multivariate data by variable stability scaling: application to NMR-based metabolic profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

Systems Toxicology: Integrated Genomic, Proteomic and Metabonomic Analysis of Methapyrilene Induced Hepatotoxicity in the Rat

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.8.7.731

21 January 2018

Identifiers

DOI

10.2217/14622416.8.7.731

1 reference

18 August 2017

1 reference

PubMed ID

18240906