Oligonucleotide antiviral therapeutics: antisense and RNA interference for highly pathogenic RNA viruses (Q37079391)

18 August 2017

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title

Oligonucleotide antiviral therapeutics: antisense and RNA interference for highly pathogenic RNA viruses (English)

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18 August 2017

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4

Sina Bavari

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18 August 2017

Kevin B Spurgers

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18 August 2017

C Matthew Sharkey

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2

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18 August 2017

Kelly L Warfield

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3

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18 August 2017

language of work or name

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14 January 2008

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18 August 2017

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18 August 2017

78

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18 August 2017

1

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18 August 2017

26-36

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Marburg and Ebola viruses as aerosol threats

18 August 2017

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12 December 2020

Induction and suppression of RNA silencing: insights from viral infections

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12 December 2020

Inhibition of SARS-CoV replication cycle by small interference RNAs silencing specific SARS proteins, 7a/7b, 3a/3b and S.

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12 December 2020

Construction of influenza virus siRNA expression vectors and their inhibitory effects on multiplication of influenza virus

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12 December 2020

Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway

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12 December 2020

Pharmacokinetics, biodistribution, stability and toxicity of a cell-penetrating peptide-morpholino oligomer conjugate.

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12 December 2020

MicroRNAs: genomics, biogenesis, mechanism, and function

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12 December 2020

Inhibition of multiple subtypes of influenza A virus in cell cultures with morpholino oligomers

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12 December 2020

Specific inhibition of influenza virus RNA polymerase and nucleoprotein genes expression by liposomally endocapsulated antisense phosphorothioate oligonucleotides: penetration and localization of oligonucleotides in clone 76 cells

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12 December 2020

siRNAs targeting terminal sequences of the SARS-associated coronavirus membrane gene inhibit M protein expression through degradation of M mRNA.

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12 December 2020

Treatment of Marburg and Ebola hemorrhagic fevers: a strategy for testing new drugs and vaccines under outbreak conditions

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12 December 2020

Evidence that HIV-1 encodes an siRNA and a suppressor of RNA silencing.

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12 December 2020

A single siRNA suppresses fatal encephalitis induced by two different flaviviruses

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12 December 2020

Protection against lethal influenza virus challenge by RNA interference in vivo.

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12 December 2020

Nucleic-acid-based antiviral agents against positive single-stranded RNA viruses

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12 December 2020

Prophylactic and therapeutic effects of small interfering RNA targeting SARS-coronavirus

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12 December 2020

Toxicology of antisense therapeutics

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12 December 2020

Problems in interpretation of data derived from in vitro and in vivo use of antisense oligodeoxynucleotides

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12 December 2020

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12 December 2020

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

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12 December 2020

Inhibition of multiple strains of Venezuelan equine encephalitis virus by a pool of four short interfering RNAs

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12 December 2020

2'-Modified oligonucleotides for antisense therapeutics

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12 December 2020

Innate immune defense through RNA interference

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12 December 2020

Effective small interfering RNAs targeting matrix and nucleocapsid protein gene inhibit influenza A virus replication in cells and mice

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12 December 2020

Inhibition of dengue virus serotypes 1 to 4 in vero cell cultures with morpholino oligomers

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12 December 2020

Marburg hemorrhagic fever--the forgotten cousin strikes.

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12 December 2020

Significance in Replication of the Terminal Nucleotides of the Flavivirus Genome

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12 December 2020

Antisense peptide-phosphorodiamidate morpholino oligomer conjugate: dose-response in mice infected with Escherichia coli.

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12 December 2020

Inhibition of Marburg virus protein expression and viral release by RNA interference

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12 December 2020

Antisense oligonucleotides directed against the viral RNA polymerase gene enhance survival of mice infected with influenza A.

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12 December 2020

Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models

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12 December 2020

Broad-spectrum antiviral activity of small interfering RNA targeting the conserved RNA termini of Lassa virus

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12 December 2020

Antiviral applications of RNAi for coronavirus

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12 December 2020

Venezuelan equine encephalitis

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12 December 2020

Identification of a novel coronavirus in patients with severe acute respiratory syndrome

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12 December 2020

An Ebola epidemic simmers in Africa: in remote region, outbreak shows staying power

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12 December 2020

Inhibition of influenza virus RNA polymerase and nucleoprotein genes expression by unmodified, phosphorothioated, and liposomally encapsulated oligonucleotides

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12 December 2020

Analysis of gene function in somatic mammalian cells using small interfering RNAs

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12 December 2020

Technology evaluation: fomivirsen, Isis Pharmaceuticals Inc/CIBA vision

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12 December 2020

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

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12 December 2020

Inhibition of highly pathogenic avian H5N1 influenza virus replication by RNA oligonucleotides targeting NS1 gene.

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12 December 2020

Inhibition of influenza virus production in virus-infected mice by RNA interference

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12 December 2020

Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide

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12 December 2020

Morpholino, siRNA, and S-DNA compared: impact of structure and mechanism of action on off-target effects and sequence specificity

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12 December 2020

The effect of the methods for producing an experimental Marburg virus infection on the characteristics of the course of the disease in green monkeys

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12 December 2020

The promise of siRNAs for the treatment of influenza

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12 December 2020

Ribonuclease H levels during the response of bovine lymphocytes to concanavalin A

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12 December 2020

Fomivirsen: clinical pharmacology and potential drug interactions

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12 December 2020

Purification, subunit structure, and serologicai analysis of calf thymus ribonuclease H I

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12 December 2020

Morpholino antisense oligomers: the case for an RNase H-independent structural type

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12 December 2020

Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque

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12 December 2020

Biology of influenza a virus.

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12 December 2020

Substrate specificity of human RNase H1 and its role in excision repair of ribose residues misincorporated in DNA

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12 December 2020

Enzymatic completion of mammalian lagging-strand DNA replication

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12 December 2020

Antisense oligonucleotides: from design to therapeutic application

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12 December 2020

Gene-specific countermeasures against Ebola virus based on antisense phosphorodiamidate morpholino oligomers.

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12 December 2020

Current and future antiviral therapy of severe seasonal and avian influenza

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12 December 2020

Assembly and function of RNA silencing complexes

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12 December 2020

DEQOR: a web-based tool for the design and quality control of siRNAs

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12 December 2020

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12 December 2020

Immense promises for tiny molecules: uncovering miRNA functions

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12 December 2020

The molecular biology of SARS coronavirus

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12 December 2020

Phosphorothioate oligodeoxynucleotides: antisense or anti-protein?

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12 December 2020

RNA interference and innate immunity

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12 December 2020

In vitro resistance selection and in vivo efficacy of morpholino oligomers against West Nile virus

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12 December 2020

Interfering with disease: a progress report on siRNA-based therapeutics

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12 December 2020

Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomers

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12 December 2020

Does antiviral therapy have a role in the control of Japanese encephalitis?

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12 December 2020

The nuclear RNase III Drosha initiates microRNA processing

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12 December 2020

Inhibition of dengue virus translation and RNA synthesis by a morpholino oligomer targeted to the top of the terminal 3' stem-loop structure

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12 December 2020

The microRNA: overview of the RNA gene that modulates gene functions

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12 December 2020

Postexposure protection of guinea pigs against a lethal ebola virus challenge is conferred by RNA interference

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12 December 2020

Inhibition of West Nile virus replication by short interfering RNAs.

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12 December 2020

New opportunities for field research on the pathogenesis and treatment of Lassa fever

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12 December 2020

Pathogenesis of West Nile Virus Infection: a Balance between Virulence, Innate and Adaptive Immunity, and Viral Evasion

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12 December 2020

Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication

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12 December 2020

Characterization of a novel coronavirus associated with severe acute respiratory syndrome

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12 December 2020

Control of HIV-1 replication by RNA interference

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12 December 2020

Transvascular delivery of small interfering RNA to the central nervous system.

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12 December 2020

On the art of identifying effective and specific siRNAs

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12 December 2020

Cell penetration by transportan.

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12 December 2020

VP35 knockdown inhibits Ebola virus amplification and protects against lethal infection in mice

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12 December 2020

The Ebola virus VP35 protein is a suppressor of RNA silencing

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12 December 2020

Phenotypic silencing of cytoplasmic genes using sequence-specific double-stranded short interfering RNA and its application in the reverse genetics of wild type negative-strand RNA viruses

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12 December 2020

siRNA--getting the message out.

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12 December 2020

Expression of vector-based small interfering RNA against West Nile virus effectively inhibits virus replication

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12 December 2020

Coronavirus as a possible cause of severe acute respiratory syndrome

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12 December 2020

sIR: siRNA Information Resource, a web-based tool for siRNA sequence design and analysis and an open access siRNA database

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12 December 2020

Chemical modifications to improve the cellular uptake of oligonucleotides

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12 December 2020

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

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12 December 2020

Updating the Accounts: Global Mortality of the 1918-1920 "Spanish" Influenza Pandemic

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12 December 2020

Human cytomegalovirus DNA replication: antiviral targets and drugs

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12 December 2020

10.1016/J.ANTIVIRAL.2007.12.008

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DOI

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18 August 2017

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