Molecular and cellular aspects of sepsis-induced immunosuppression (Q37079814)

18 August 2017

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title

Molecular and cellular aspects of sepsis-induced immunosuppression (English)

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18 August 2017

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Tisha S Wang

1

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PubMed ID

18259721

18 August 2017

Jane C Deng

series ordinal

2

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18 August 2017

8 February 2008

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Journal of Molecular Medicine

18 August 2017

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18 August 2017

86

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18 August 2017

495-506

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18 August 2017

5

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https://scigraph.springernature.com/pub.10.1007/s00109-007-0300-4

18 August 2017

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Intrapulmonary TNF gene therapy reverses sepsis-induced suppression of lung antibacterial host defense

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Regulation of the class II MHC pathway in primary human monocytes by granulocyte-macrophage colony-stimulating factor.

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Characterization of the systemic loss of dendritic cells in murine lymph nodes during polymicrobial sepsis

21 January 2018

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Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease

21 January 2018

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Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells

21 January 2018

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NF-kappaB expression in mononuclear cells of patients with sepsis resembles that observed in lipopolysaccharide tolerance

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Chronic sepsis mortality characterized by an individualized inflammatory response

21 January 2018

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Normal responses to injury prevent systemic inflammation and can be immunosuppressive

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A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock

21 January 2018

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Effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis

21 January 2018

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Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels

21 January 2018

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Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock

21 January 2018

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12 December 2020

Down-modulation of granulocyte macrophage-colony stimulating factor receptor on monocytes during human septic shock.

1 reference

12 December 2020

Gamma interferon and granulocyte/monocyte colony-stimulating factor prevent endotoxin tolerance in human monocytes by promoting interleukin-1 receptor-associated kinase expression and its association to MyD88 and not by modulating TLR4 expression

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12 December 2020

Clinical review: immunodepression in the surgical patient and increased susceptibility to infection

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12 December 2020

Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms

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12 December 2020

IRAK-M is a negative regulator of Toll-like receptor signaling

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12 December 2020

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

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12 December 2020

Laboratory models of sepsis and septic shock

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12 December 2020

Anti-inflammatory cytokines

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12 December 2020

Reversal of long-term sepsis-induced immunosuppression by dendritic cells.

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12 December 2020

The anti-inflammatory response dominates after septic shock: association of low monocyte HLA-DR expression and high interleukin-10 concentration

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12 December 2020

Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans

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12 December 2020

A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways.

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12 December 2020

Endotoxin shock. Hemodynamic and survival effects of methylprednisolone

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12 December 2020

Magnitude and duration of the effect of sepsis on survival. Department of Veterans Affairs Systemic Sepsis Cooperative Studies Group

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12 December 2020

Monocyte deactivation--rationale for a new therapeutic strategy in sepsis

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12 December 2020

Lymphocyte counts and the development of nosocomial sepsis

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12 December 2020

Statins and sepsis in patients with cardiovascular disease: a population-based cohort analysis

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12 December 2020

Genomic variations and susceptibility to sepsis

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12 December 2020

Lower levels of whole blood LPS-stimulated cytokine release are associated with poorer clinical outcomes in surgical ICU patients.

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12 December 2020

A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection

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12 December 2020

The -260 C-->T promoter polymorphism of the lipopolysaccharide receptor CD14 and severe sepsis in trauma patients.

1 reference

12 December 2020

Anti-inflammatory cytokine profile and mortality in febrile patients.

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12 December 2020

Toll-like receptor (TLR) response tolerance: a key physiological "damage limitation" effect and an important potential opportunity for therapy.

1 reference

12 December 2020

Gram-negative sepsis. Background, clinical features, and intervention

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12 December 2020

Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock

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12 December 2020

Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis

1 reference

12 December 2020

1 reference

12 December 2020

Immunosuppressive effects of apoptotic cells

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12 December 2020

Injury induces deficient interleukin-12 production, but interleukin-12 therapy after injury restores resistance to infection

1 reference

12 December 2020

Altered leukocyte immunophenotypes in septic shock. Studies of HLA-DR, CD11b, CD14, and IL-2R expression

1 reference

12 December 2020

Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways

1 reference

12 December 2020

Innate immunity SNPs are associated with risk for severe sepsis after burn injury

1 reference

12 December 2020

Bench-to-bedside review: endotoxin tolerance as a model of leukocyte reprogramming in sepsis

1 reference

12 December 2020

Interferon gamma-1b in the treatment of compensatory anti-inflammatory response syndrome. A new approach: proof of principle.

1 reference

12 December 2020

Statins and outcomes in patients admitted to hospital with community acquired pneumonia: population based prospective cohort study

1 reference

12 December 2020

Role of interleukin-10 in the intracellular sequestration of human leukocyte antigen-DR in monocytes during septic shock

1 reference

12 December 2020

Failure of neutrophil chemotactic function in septic patients.

1 reference

12 December 2020

Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction

1 reference

12 December 2020

Depletion of dendritic cells, but not macrophages, in patients with sepsis

1 reference

12 December 2020

Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M.

1 reference

12 December 2020

Dysregulation of the immune response in severe sepsis

1 reference

12 December 2020

Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. The Soluble TNF Receptor Sepsis Study Group

1 reference

12 December 2020

Severe sepsis exacerbates cell-mediated immunity in the lung due to an altered dendritic cell cytokine profile

1 reference

12 December 2020

Monocyte response to bacterial toxins, expression of cell surface receptors, and release of anti-inflammatory cytokines during sepsis

1 reference

12 December 2020

Functional significance of CXCR2 downregulation on neutrophils from patients with severe sepsis

1 reference

12 December 2020

Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections

1 reference

12 December 2020

Multicenter, double-blind, placebo-controlled study of the use of filgrastim in patients hospitalized with pneumonia and severe sepsis

1 reference

12 December 2020

Surgical trauma and immunosuppression: pathophysiology and potential immunomodulatory approaches

1 reference

12 December 2020

Role of nitric oxide in the failure of neutrophil migration in sepsis

1 reference

12 December 2020

CXC chemokine receptor CXCR2 is essential for protective innate host response in murine Pseudomonas aeruginosa pneumonia

1 reference

12 December 2020

Genetic influence on cytokine production and fatal meningococcal disease

1 reference

12 December 2020

Differential effects of necrotic or apoptotic cell uptake on antigen presentation by macrophages

1 reference

12 December 2020

Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care

1 reference

12 December 2020

Gram-negative flagellin-induced self-tolerance is associated with a block in interleukin-1 receptor-associated kinase release from toll-like receptor 5.

1 reference

12 December 2020

Statins and sepsis: multiple modifications at multiple levels.

1 reference

12 December 2020

IL-10 is a major mediator of sepsis-induced impairment in lung antibacterial host defense

1 reference

12 December 2020

Cytokine promoter polymorphisms in severe sepsis

1 reference

12 December 2020

Tolerance to lipopolysaccharide involves mobilization of nuclear factor kappa B with predominance of p50 homodimers

1 reference

12 December 2020

The pathophysiology and treatment of sepsis

1 reference

12 December 2020

Gender differences in the innate immune response and vascular reactivity following the administration of endotoxin to human volunteers.

1 reference

12 December 2020

Dysregulation of in vitro cytokine production by monocytes during sepsis

1 reference

12 December 2020

Monocytes/macrophages and sepsis

1 reference

12 December 2020

Induction of bacterial lipoprotein tolerance is associated with suppression of toll-like receptor 2 expression

1 reference

12 December 2020

Corticosteroid treatment for sepsis: a critical appraisal and meta-analysis of the literature.

1 reference

12 December 2020

Monocyte deactivation in septic patients: restoration by IFN-gamma treatment

1 reference

12 December 2020

Response of tumour necrosis factor-alpha to delayed in vitro monocyte stimulation in patients with septic shock is related to outcome

1 reference

12 December 2020

Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine

1 reference

12 December 2020

Characterization of interleukin-1 receptor-associated kinase in normal and endotoxin-tolerant cells

1 reference

12 December 2020

Delayed hypersensitivity: indicator of acquired failure of host defenses in sepsis and trauma

1 reference

12 December 2020

Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock

1 reference

12 December 2020

Mechanisms of mortality in early and late sepsis.

1 reference

12 December 2020

Differential expression of interleukin-1 and tumor necrosis factor in murine septic shock models

1 reference

12 December 2020

The epidemiology of sepsis in the United States from 1979 through 2000

1 reference

12 December 2020

Decreased monocyte human leukocyte antigen-DR expression after severe burn injury: Correlation with severity and secondary septic shock

1 reference

12 December 2020

Dendritic cells during polymicrobial sepsis rapidly mature but fail to initiate a protective Th1-type immune response

1 reference

12 December 2020

Genetic polymorphisms and sepsis.

1 reference

12 December 2020

Effects of CD14-159 C/T polymorphism on CD14 expression and the balance between proinflammatory and anti-inflammatory cytokines in whole blood culture

1 reference

12 December 2020

Impaired neutrophil adherence as an early marker of systemic inflammatory response syndrome and severe sepsis

1 reference

12 December 2020

Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice

1 reference

12 December 2020

Harmful and protective roles of neutrophils in sepsis

1 reference

12 December 2020

Involvement of IRAK-M in peptidoglycan-induced tolerance in macrophages

1 reference

12 December 2020

Reversal of immunoparalysis by recombinant human granulocyte-macrophage colony-stimulating factor in patients with severe sepsis

1 reference

12 December 2020

Sepsis induces apoptosis and profound depletion of splenic interdigitating and follicular dendritic cells

1 reference

12 December 2020

Induction of cross-tolerance by lipopolysaccharide and highly purified lipoteichoic acid via different Toll-like receptors independent of paracrine mediators

1 reference

12 December 2020

Trauma-hemorrhage induces depressed splenic dendritic cell functions in mice

1 reference

12 December 2020

Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-gamma : a molecular basis for priming and synergism with bacterial lipopolysaccharide

1 reference

12 December 2020

Pattern of cytokines and pharmacomodulation in sepsis induced by cecal ligation and puncture compared with that induced by endotoxin.

1 reference

12 December 2020

Tumor necrosis factor and interleukin-1 in the serum of children with severe infectious purpura

1 reference

12 December 2020

Interleukin-12 treatment restores normal resistance to bacterial challenge after burn injury

1 reference

12 December 2020

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans

1 reference

12 December 2020

Cytokines and anticytokines in the pathogenesis of sepsis

1 reference

12 December 2020

Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options

1 reference

12 December 2020

A randomized phase II trial of granulocyte-macrophage colony-stimulating factor therapy in severe sepsis with respiratory dysfunction.

1 reference

12 December 2020

Severe sepsis in managed care: analysis of incidence, one-year mortality, and associated costs of care

1 reference

12 December 2020

Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte

1 reference

12 December 2020

Cytokine therapeutics for the treatment of sepsis: why has nothing worked?

1 reference

12 December 2020

Sepsis-induced immunosuppression: from bad to worse

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12 December 2020

Genetics of individualizing patient care

1 reference

12 December 2020

Association between a genomic polymorphism within the CD14 locus and septic shock susceptibility and mortality rate

1 reference

12 December 2020

Leukocyte activation in sepsis; correlations with disease state and mortality

1 reference

12 December 2020

Is the measurement of monocytes HLA-DR expression useful in patients with sepsis?

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12 December 2020

Polymicrobial sepsis induces divergent effects on splenic and peritoneal dendritic cell function in mice

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12 December 2020

Rapid up-regulation of IRAK-M expression following a second endotoxin challenge in human monocytes and in monocytes isolated from septic patients

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12 December 2020

Prevention of lymphocyte cell death in sepsis improves survival in mice

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12 December 2020

Pre- and postoperative cytokine release after in vitro whole blood lipopolysaccharide stimulation and frequent toll-like receptor 4 polymorphisms.

1 reference

12 December 2020

10.1007/S00109-007-0300-4

Identifiers

DOI

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18 August 2017

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PubMed ID

18259721