Use of the Rad51 promoter for targeted anti-cancer therapy (Q37081622)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19106292%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

title

Use of the Rad51 promoter for targeted anti-cancer therapy (English)

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19 January 2020

1

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19 January 2020

Vera Gorbunova

series ordinal

3

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19 January 2020

author name string

Andrei Seluanov

series ordinal

2

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19 January 2020

language of work or name

English

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publication date

23 December 2008

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Proceedings of the National Academy of Sciences of the United States of America

19 January 2020

published in

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19 January 2020

volume

105

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19 January 2020

issue

52

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19 January 2020

page(s)

20810-20815

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RAD51 135G-->C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies

19 January 2020

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Rad51 overexpression contributes to chemoresistance in human soft tissue sarcoma cells: a role for p53/activator protein 2 transcriptional regulation

29 September 2017

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Telomerase-specific oncolytic virotherapy for human cancer with the hTERT promoter

29 September 2017

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29 September 2017

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Characterisation of the promoter region of the human DNA-repair gene Rad51

29 September 2017

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Properties of a telomerase-specific Cre/Lox switch for transcriptionally targeted cancer gene therapy.

29 September 2017

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p53 modulates homologous recombination by transcriptional regulation of the RAD51 gene

29 September 2017

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29 September 2017

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High-level expression of Rad51 is an independent prognostic marker of survival in non-small-cell lung cancer patients

29 September 2017

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The RAD51 gene family, genetic instability and cancer

29 September 2017

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RAD51, genomic stability, and tumorigenesis

29 September 2017

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The life and death of DNA-PK.

29 September 2017

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Midkine promoter-driven suicide gene expression and -mediated adenovirus replication produced cytotoxic effects to immortalised and tumour cells

29 September 2017

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Gleevec-mediated inhibition of Rad51 expression and enhancement of tumor cell radiosensitivity

29 September 2017

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Transcriptionally targeted gene therapy to detect and treat cancer

29 September 2017

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Telomerase promoter-driven cancer gene therapy

29 September 2017

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p53 interacts with hRAD51 and hRAD54, and directly modulates homologous recombination

29 September 2017

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Fusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair, prolongation of G(2)/M phase, and protection from apoptosis

29 September 2017

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Elevated levels of Rad51 recombination protein in tumor cells.

29 September 2017

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BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance

29 September 2017

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The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promoters

29 September 2017

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Ribozyme minigene-mediated RAD51 down-regulation increases radiosensitivity of human prostate cancer cells

29 September 2017

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RAD51 supports spontaneous non-homologous recombination in mammalian cells, but not the corresponding process induced by topoisomerase inhibitors

29 September 2017

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Use of transcriptional regulatory sequences of telomerase (hTER and hTERT) for selective killing of cancer cells

29 September 2017

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Over-expression of wild-type Rad51 correlates with histological grading of invasive ductal breast cancer

29 September 2017

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DNA repair and recombination factor Rad51 is over-expressed in human pancreatic adenocarcinoma

29 September 2017

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Prostate-specific antigen promoter/enhancer driven gene therapy for prostate cancer: construction and testing of a tissue-specific adenovirus vector.

29 September 2017

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In vitro and in vivo potentiation of radiosensitivity of malignant gliomas by antisense inhibition of the RAD51 gene

29 September 2017

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Elevated recombination in immortal human cells is mediated by HsRAD51 recombinase

29 September 2017

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Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro

29 September 2017

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Role of the human RAD51 protein in homologous recombination and double-stranded-break repair

29 September 2017

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27 June 2018

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27 June 2018

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Cancer-specific activation of the survivin promoter and its potential use in gene therapy

3 September 2018

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Rad51 overexpression promotes alternative double-strand break repair pathways and genome instability

3 September 2018

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Direct interstitial infusion of NK1-targeted neurotoxin into the spinal cord: a computational model

3 September 2018

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Tumor-specific activation of hTERT-derived promoters by tumor suppressive E1A-mutants involves recruitment of p300/CBP/HAT and suppression of HDAC-1 and defines a combined tumor targeting and suppression system

3 September 2018

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Novel oncolytic adenoviruses targeted to melanoma: specific viral replication and cytolysis by expression of E1A mutants from the tyrosinase enhancer/promoter

3 September 2018

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Treatment of malignant glioma cells with the transfer of constitutively active caspase-6 using the human telomerase catalytic subunit (human telomerase reverse transcriptase) gene promoter.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2634908

Tumor-specific transgene expression from the human telomerase reverse transcriptase promoter enables targeting of the therapeutic effects of the Bax gene to cancers.

3 September 2018

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A novel telomerase-specific gene therapy: gene transfer of caspase-8 utilizing the human telomerase catalytic subunit gene promoter

3 September 2018

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A telomerase-dependent conditionally replicating adenovirus for selective treatment of cancer

3 September 2018

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12 December 2020

One molecule of diphtheria toxin fragment A introduced into a cell can kill the cell

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12 December 2020

Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

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12 December 2020

Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells

1 reference

12 December 2020

Characterization of the human Rad51 genomic locus and examination of tumors with 15q14-15 loss of heterozygosity (LOH)

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0807990106

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19 January 2020

0 references

1 reference

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19 January 2020

PubMed publication ID

19106292

1 reference