Beta cell mass in diabetes: a realistic therapeutic target? (Q37101311)

18 August 2017

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title

Beta cell mass in diabetes: a realistic therapeutic target? (English)

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18 August 2017

J J Meier

1

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18 August 2017

4 March 2008

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18 August 2017

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18 August 2017

51

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18 August 2017

5

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18 August 2017

703-713

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https://scigraph.springernature.com/pub.10.1007/s00125-008-0936-9

18 August 2017

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Effects of hemipancreatectomy on insulin secretion and glucose tolerance in healthy humans.

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Functional Maturation and Proliferation of Fetal Pancreatic β-Cells

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Decrease in beta-cell mass leads to impaired pulsatile insulin secretion, reduced postprandial hepatic insulin clearance, and relative hyperglucagonemia in the minipig

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12 December 2020

Compensatory Growth of Pancreatic -Cells in Adult Rats After Short-Term Glucose Infusion

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12 December 2020

Quantitative study of insulin secretion and clearance in normal and obese subjects

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12 December 2020

In humans at least 75% of insulin secretion arises from punctuated insulin secretory bursts

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12 December 2020

Cyclosporine delays but does not prevent clinical onset in glucose intolerant pre-type 1 diabetic children

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12 December 2020

Pathologic anatomy of the pancreas in juvenile diabetes mellitus

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12 December 2020

Morphometric evidence for a striking B-cell reduction at the clinical onset of type 1 diabetes

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12 December 2020

Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid

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12 December 2020

Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets

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12 December 2020

A morphological study of the endocrine pancreas in human pregnancy

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12 December 2020

Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin.

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12 December 2020

Plasma Insulin Responses to Oral and Intravenous Glucose: Studies in Normal and Diabetic Subjects*

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12 December 2020

Restoration of early rise in plasma insulin levels improves the glucose tolerance of type 2 diabetic patients

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12 December 2020

Postprandial suppression of glucagon secretion depends on intact pulsatile insulin secretion: further evidence for the intraislet insulin hypothesis.

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12 December 2020

beta-cell turnover: its assessment and implications

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12 December 2020

Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes

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12 December 2020

Glucokinase as pancreatic beta cell glucose sensor and diabetes gene

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12 December 2020

The genetic basis of type 2 diabetes mellitus: impaired insulin secretion versus impaired insulin sensitivity.

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12 December 2020

Hyperinsulinemic hypoglycemia after gastric bypass surgery is not accompanied by islet hyperplasia or increased beta-cell turnover

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12 December 2020

Regulation of pancreatic beta-cell regeneration in the normoglycemic 60% partial-pancreatectomy mouse.

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12 December 2020

Sulfonylurea induced beta-cell apoptosis in cultured human islets

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12 December 2020

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

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12 December 2020

Measurement of pancreatic islet cell proliferation by heavy water labeling.

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12 December 2020

A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development

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12 December 2020

Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model.

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12 December 2020

Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release

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12 December 2020

Relationship between beta-cell mass and fasting blood glucose concentration in humans

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12 December 2020

Involvement of capsaicin-sensitive nerves in regulation of insulin secretion and glucose tolerance in conscious mice

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12 December 2020

Normal relationship of beta- and non-beta-cells not needed for successful islet transplantation.

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12 December 2020

Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration

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12 December 2020

Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells

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12 December 2020

Residual insulin positivity and pancreatic atrophy in relation to duration of chronic Type 1 (insulin-dependent) diabetes mellitus and microangiopathy

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12 December 2020

Nicotinamide protects human beta cells against chemically-induced necrosis, but not against cytokine-induced apoptosis

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12 December 2020

UKPDS 26: Sulphonylurea failure in non-insulin-dependent diabetic patients over six years. UK Prospective Diabetes Study (UKPDS) Group.

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12 December 2020

Extra-insular beta cells associated with ductules are frequent in adult human pancreas.

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12 December 2020

Regulation of alpha-cell function by the beta-cell during hypoglycemia in Wistar rats: the "switch-off" hypothesis

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12 December 2020

Proliferation and differentiation in the human fetal endocrine pancreas

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12 December 2020

Exenatide augments first- and second-phase insulin secretion in response to intravenous glucose in subjects with type 2 diabetes

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12 December 2020

Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus

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12 December 2020

Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus

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12 December 2020

Islet transplantation as a treatment for diabetes - a work in progress

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12 December 2020

The order of islet microvascular cellular perfusion is B----A----D in the perfused rat pancreas

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12 December 2020

Pulsatile insulin secretion dictates systemic insulin delivery by regulating hepatic insulin extraction in humans

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12 December 2020

Estimation of beta-cell mass by metabolic tests: necessary, but how sufficient?

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12 December 2020

The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

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12 December 2020

Successful islet transplantation for patients with diabetes--fact or fantasy?

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12 December 2020

Increased islet beta cell replication adjacent to intrapancreatic gastrinomas in humans.

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12 December 2020

Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration?

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12 December 2020

Effect of intensive therapy on residual beta-cell function in patients with type 1 diabetes in the diabetes control and complications trial. A randomized, controlled trial. The Diabetes Control and Complications Trial Research Group

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12 December 2020

A comparison of twice-daily exenatide and biphasic insulin aspart in patients with type 2 diabetes who were suboptimally controlled with sulfonylurea and metformin: a non-inferiority study.

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12 December 2020

Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective po

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12 December 2020

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

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12 December 2020

Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice

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12 December 2020

Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats.

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12 December 2020

Effect of exenatide on beta cell function after islet transplantation in type 1 diabetes

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12 December 2020

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

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12 December 2020

Combined pancreas and kidney transplantation in a lean type 2 diabetic patient. Effects on insulin secretion and sensitivity

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12 December 2020

Long-term treatment with rosiglitazone and metformin reduces the extent of, but does not prevent, islet amyloid deposition in mice expressing the gene for human islet amyloid polypeptide

1 reference

12 December 2020

Effect of strict blood glucose control on residual B-cell function in insulin-dependent diabetics.

1 reference

12 December 2020

Apoptosis participates in the remodeling of the endocrine pancreas in the neonatal rat.

1 reference

12 December 2020

Insulin secretion in diabetes mellitus

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12 December 2020

Effects of age, duration and treatment of insulin-dependent diabetes mellitus on residual beta-cell function: observations during eligibility testing for the Diabetes Control and Complications Trial (DCCT). The DCCT Research Group

1 reference

12 December 2020

Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus

1 reference

12 December 2020

Five-year follow-up after clinical islet transplantation

1 reference

12 December 2020

Prevalence of residual B cell function and its metabolic consequences in Type 1 (insulin-dependent) diabetes

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12 December 2020

Increased beta-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse.

1 reference

12 December 2020

Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes

1 reference

12 December 2020

Safety and efficacy of normalizing fasting glucose with bedtime NPH insulin alone in NIDDM.

1 reference

12 December 2020

High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes

1 reference

12 December 2020

Diazoxide treatment at onset preserves residual insulin secretion in adults with autoimmune diabetes

1 reference

12 December 2020

Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial

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12 December 2020

Gestational diabetes mellitus

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12 December 2020

The rise and fall of insulin secretion in type 1 diabetes mellitus

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12 December 2020

Effects of a 48-h fat infusion on insulin secretion and glucose utilization

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12 December 2020

The potential for stem cell therapy in diabetes.

1 reference

12 December 2020

Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3'-kinase-dependent pathway.

1 reference

12 December 2020

The direct effects of the angiotensin-converting enzyme inhibitors, zofenoprilat and enalaprilat, on isolated human pancreatic islets

1 reference

12 December 2020

Successful islet autotransplantation in humans: functional insulin secretory reserve as an estimate of surviving islet cell mass

1 reference

12 December 2020

Modestly increased beta cell apoptosis but no increased beta cell replication in recent-onset type 1 diabetic patients who died of diabetic ketoacidosis

1 reference

12 December 2020

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats

1 reference

12 December 2020

Successful islet transplantation: continued insulin reserve provides long-term glycemic control

1 reference

12 December 2020

Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes

1 reference

12 December 2020

Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes

1 reference

12 December 2020

Pancreatic beta cells in insulin-dependent diabetes

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12 December 2020

Banting lecture 1988. Role of insulin resistance in human disease

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12 December 2020

Overnight inhibition of insulin secretion restores pulsatility and proinsulin/insulin ratio in type 2 diabetes.

1 reference

12 December 2020

Induction of beta-cell rest by a Kir6.2/SUR1-selective K(ATP)-channel opener preserves beta-cell insulin stores and insulin secretion in human islets cultured at high (11 mM) glucose

1 reference

12 December 2020

On the track to the beta-cell

1 reference

12 December 2020

Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones

1 reference

12 December 2020

Very slow turnover of beta-cells in aged adult mice

1 reference

12 December 2020

Beneficial effects of insulin versus sulphonylurea on insulin secretion and metabolic control in recently diagnosed type 2 diabetic patients

1 reference

12 December 2020

Beta-cell deficit due to increased apoptosis in the human islet amyloid polypeptide transgenic (HIP) rat recapitulates the metabolic defects present in type 2 diabetes.

1 reference

12 December 2020

Outcomes of pancreas transplants for patients with type 2 diabetes mellitus

1 reference

12 December 2020

Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy

1 reference

12 December 2020

Insulin insensitivity in type 1 diabetes

1 reference

12 December 2020

10.1007/S00125-008-0936-9

Identifiers

DOI

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18 August 2017

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PubMed ID

18317728