Oncogenic AKT1(E17K) mutation induces mammary hyperplasia but prevents HER2-driven tumorigenesis. (Q37109462)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27004402%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

title

Oncogenic AKT1(E17K) mutation induces mammary hyperplasia but prevents HER2-driven tumorigenesis (English)

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30 March 2020

2

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30 March 2020

author name string

Maria L Mancini

series ordinal

1

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30 March 2020

Alex Toker

series ordinal

3

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30 March 2020

language of work or name

English

0 references

publication date

1 April 2016

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30 March 2020

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30 March 2020

volume

7

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30 March 2020

issue

14

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30 March 2020

page(s)

17301-17313

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Antagonism of EGFR and HER3 enhances the response to inhibitors of the PI3K-Akt pathway in triple-negative breast cancer

30 March 2020

cites work

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PIK3CA and AKT1 mutations have distinct effects on sensitivity to targeted pathway inhibitors in an isogenic luminal breast cancer model system.

14 September 2017

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Cancer associated E17K mutation causes rapid conformational drift in AKT1 pleckstrin homology (PH) domain

14 September 2017

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14 September 2017

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Sequence analysis of mutations and translocations across breast cancer subtypes

14 September 2017

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14 September 2017

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Differential effects of AKT1(p.E17K) expression on human mammary luminal epithelial and myoepithelial cells

14 September 2017

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Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancer

14 September 2017

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AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity

14 September 2017

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The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration

14 September 2017

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14 September 2017

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Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations

14 September 2017

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AKT1 pleckstrin homology domain E17K activating mutation in endometrial carcinoma

14 September 2017

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14 September 2017

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The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas

14 September 2017

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Phosphatidylinositol-3-kinase and AKT1 mutations occur early in breast carcinoma

14 September 2017

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AKT1 E17 K pleckstrin homology domain mutation in urothelial carcinoma

14 September 2017

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Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer.

14 September 2017

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Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain

14 September 2017

1 reference

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A novel AKT3 mutation in melanoma tumours and cell lines

14 September 2017

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The role of PTEN signaling perturbations in cancer and in targeted therapy

14 September 2017

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Activated Akt1 accelerates MMTV-c-ErbB2 mammary tumourigenesis in mice without activation of ErbB3.

14 September 2017

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An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer

14 September 2017

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A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

14 September 2017

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AKT/PKB signaling: navigating downstream

14 September 2017

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Molecular and cellular determinants of estrogen receptor alpha expression

14 September 2017

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Oestrogen exposure and breast cancer risk

14 September 2017

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Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression

14 September 2017

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Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase

14 September 2017

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Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin

14 September 2017

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E17K substitution in AKT1 in prostate cancer

14 September 2017

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AKT1 mutations in bladder cancer: identification of a novel oncogenic mutation that can co-operate with E17K.

29 September 2017

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Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung

29 September 2017

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Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin.

29 September 2017

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Mechanism of activation and function of protein kinase B.

27 June 2018

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Conditional gene expression in secretory tissues and skin of transgenic mice using the MMTV-LTR and the tetracycline responsive system

27 June 2018

1 reference

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Estrogen-dependent, tamoxifen-resistant tumorigenic growth of MCF-7 cells transfected with HER2/neu

27 June 2018

1 reference

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AKT1(E17K) in human solid tumours

27 June 2018

1 reference

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Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951213

Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951213

Mice expressing myrAKT1 in the mammary gland develop carcinogen-induced ER-positive mammary tumors that mimic human breast cancer

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951213

4 December 2018

Identifiers

DOI

10.18632/ONCOTARGET.8191

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27004402%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27004402%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

1 reference