Costimulatory pathways: physiology and potential therapeutic manipulation in systemic lupus erythematosus (Q37127290)

18 August 2017

8 references

12 March 2019

13 March 2019

17 June 2019

30 June 2019

31 July 2019

15 December 2019

26 August 2020

3 May 2021

Costimulatory pathways: physiology and potential therapeutic manipulation in systemic lupus erythematosus (English)

1 reference

systemic lupus erythematosus

18 August 2017

7 references

12 March 2019

13 March 2019

17 June 2019

30 June 2019

31 July 2019

15 December 2019

26 August 2020

cell surface receptor

1 reference

31 July 2019

1 reference

15 December 2019

1 reference

26 August 2020

1 reference

3 May 2021

0 references

Nien Yee Kow

1

1 reference

PMCID

3755444

18 August 2017

Anselm Mak

series ordinal

2

1 reference

PMCID

3755444

18 August 2017

language of work or name

1 reference

29 July 2013

9 references

Clinical and Developmental Immunology

18 August 2017

12 March 2019

13 March 2019

17 June 2019

30 June 2019

31 July 2019

15 December 2019

26 August 2020

3 May 2021

9 references

18 August 2017

12 March 2019

13 March 2019

17 June 2019

30 June 2019

31 July 2019

15 December 2019

26 August 2020

3 May 2021

2013

1 reference

18 August 2017

245928

1 reference

Creative Commons Attribution 3.0 Unported

18 August 2017

8 references

12 March 2019

13 March 2019

17 June 2019

30 June 2019

31 July 2019

15 December 2019

26 August 2020

on focus list of Wikimedia project

3 May 2021

copyright status

copyrighted

0 references

ScienceSource

0 references

cites work

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Impact of intravenous abatacept on synovitis, osteitis and structural damage in patients with rheumatoid arthritis and an inadequate response to methotrexate: the ASSET randomised controlled trial

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Abatacept for lupus nephritis: alternative definitions of complete response support conflicting conclusions

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A novel monoclonal antibody against human CD80 and its immune protection in a mouse lupus-like disease

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Pathogenesis of systemic lupus erythematosus revisited 2011: end organ resistance to damage, autoantibody initiation and diversification, and HLA-DR.

14 September 2017

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Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 family

14 September 2017

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Species difference of CD137 ligand signaling in human and murine monocytes

14 September 2017

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Significantly higher percentage of circulating CD27(high) plasma cells in systemic lupus erythematosus patients with infection than with disease flare-up

14 September 2017

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Role of CD27/CD70 pathway of activation in immunity and tolerance

14 September 2017

1 reference

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Increased expression of costimulatory markers CD134 and CD80 on interleukin-17 producing T cells in patients with systemic lupus erythematosus.

14 September 2017

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CD137 enhances monocyte-ICAM-1 interactions in an E-selectin-dependent manner under flow conditions.

14 September 2017

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Control of immunity by the TNFR-related molecule OX40 (CD134)

14 September 2017

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OX40 (CD134) and OX40L.

1 reference

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T cell CD40LG gene expression and the production of IgG by autologous B cells in systemic lupus erythematosus

14 September 2017

1 reference

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Molecular mechanism and function of CD40/CD40L engagement in the immune system.

14 September 2017

1 reference

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CD28 and CTLA-4 coreceptor expression and signal transduction

14 September 2017

1 reference

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Outside inside signalling in CD40-mediated B cell activation

14 September 2017

1 reference

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Altered signal transduction in SLE T cells

14 September 2017

1 reference

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OX40 ligand shuts down IL-10-producing regulatory T cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3755444

CD27 and CD70 in T cell and B cell activation

14 September 2017

1 reference

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Block and tackle: CTLA4Ig takes on lupus

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3755444

Costimulatory molecules and T-cell-B-cell interactions

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3755444

Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis

14 September 2017

1 reference

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CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB x NZW F1 mice

14 September 2017

1 reference

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Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

14 September 2017

1 reference

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CD137 is expressed by follicular dendritic cells and costimulates B lymphocyte activation in germinal centers

14 September 2017

1 reference

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T-cell regulation by CD28 and CTLA-4.

14 September 2017

1 reference

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ICOS is critical for CD40-mediated antibody class switching

14 September 2017

1 reference

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Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS

14 September 2017

1 reference

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Strong and selective glomerular localization of CD134 ligand and TNF receptor-1 in proliferative lupus nephritis

14 September 2017

1 reference

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CTLA4Ig inhibits T cell-dependent B-cell maturation in murine systemic lupus erythematosus

14 September 2017

1 reference

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Characterization of human inducible costimulator ligand expression and function

14 September 2017

1 reference

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B7-1 engagement of cytotoxic T lymphocyte antigen 4 inhibits T cell activation in the absence of CD28.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3755444

CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3755444

Cytotoxic T-lymphocyte-associated antigen-4.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3755444

The role of the ICOS-B7h T cell costimulatory pathway in transplantation immunity.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3755444

CD80, CD86 and CD40 provide accessory signals in a multiple-step T-cell activation model.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3755444

Engagement of CD27 with its ligand CD70 provides a second signal for T cell activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3755444

ILA, the human 4-1BB homologue, is inducible in lymphoid and other cell lineages

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3755444

NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3755444

The efficacy and safety of abatacept in patients with non-life-threatening manifestations of systemic lupus erythematosus: results of a twelve-month, multicenter, exploratory, phase IIb, randomized, double-blind, placebo-controlled trial

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3755444

Epigenetics and SLE: RFX1 downregulation causes CD11a and CD70 overexpression by altering epigenetic modifications in lupus CD4+ T cells.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3755444

Fyn and CD70 expression in CD4+ T cells from patients with systemic lupus erythematosus.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3755444

ERK/p38 MAP-kinases and PI3K are involved in the differential regulation of B7-H1 expression in DC subsets.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3755444

Effect of anti-CD134L mAb and CTLA4Ig on ConA-induced proliferation, Th cytokine secretion, and anti-dsDNA antibody production in spleen cells from lupus-prone BXSB mice.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3755444

Demethylation of CD40LG on the inactive X in T cells from women with lupus

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3755444

Effects of CD134 monoclonal antibody on hemolysis activities and expression of perforin in peripheral blood mononuclear cells of systemic lupus erythematosus patients.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3755444

CD137 is expressed on blood vessel walls at sites of inflammation and enhances monocyte migratory activity.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3755444

Role of inducible costimulator in the development of lupus in MRL/lpr mice.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3755444

Human ICOS deficiency abrogates the germinal center reaction and provides a monogenic model for common variable immunodeficiency.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3755444

Increased prevalence of activated CD70+CD4+ T cells in the periphery of patients with systemic lupus erythematosus.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3755444

Demethylation of the same promoter sequence increases CD70 expression in lupus T cells and T cells treated with lupus-inducing drugs

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3755444

B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3755444

4-1BB and OX40 dual costimulation synergistically stimulate primary specific CD8 T cells for robust effector function.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3755444

Overexpression of CD70 and overstimulation of IgG synthesis by lupus T cells and T cells treated with DNA methylation inhibitors

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3755444

Hyperexpression of inducible costimulator and its contribution on lamina propria T cells in inflammatory bowel disease.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3755444

Affinity and kinetics of the interaction between soluble trimeric OX40 ligand, a member of the tumor necrosis factor superfamily, and its receptor OX40 on activated T cells.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3755444

Treatment of murine lupus with CTLA4Ig

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3755444

Long-term inhibition of murine lupus by brief simultaneous blockade of the B7/CD28 and CD40/gp39 costimulation pathways

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3755444

Anti-CD40 ligand antibody treatment prevents the development of lupus-like nephritis in a subset of New Zealand black x New Zealand white mice. Response correlates with the absence of an anti-antibody response

20 October 2018

1 reference

12 December 2020

Histone modifications and methyl-CpG-binding domain protein levels at the TNFSF7 (CD70) promoter in SLE CD4+ T cells

1 reference

12 December 2020

Expression of CD40 and CD40 ligand among cell populations within rheumatoid synovial compartment

1 reference

12 December 2020

CD40L overexpression on T cells and monocytes from patients with systemic lupus erythematosus is resistant to calcineurin inhibition

1 reference

12 December 2020

CD4 T cell traffic control: in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles

1 reference

12 December 2020

CD134 expression on CD4+ T cells is associated with nephritis and disease activity in patients with systemic lupus erythematosus

1 reference

12 December 2020

ICOS and B7 costimulatory molecule expression identifies activated cellular subsets in rheumatoid arthritis

1 reference

12 December 2020

Defective DNA methylation and CD70 overexpression in CD4+ T cells in MRL/lpr lupus-prone mice

1 reference

12 December 2020

Role of endogenous 4-1BB in the development of systemic lupus erythematosus

1 reference

12 December 2020

CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice

1 reference

12 December 2020

Targeting the CD134-CD134L interaction using anti-CD134 and/or rhCD134 fusion protein as a possible strategy to prevent lupus nephritis

1 reference

12 December 2020

Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease

1 reference

12 December 2020

Treatment of systemic lupus erythematosus by inhibition of T cell costimulation with anti-CD154: a randomized, double-blind, placebo-controlled trial

1 reference

12 December 2020

Expression and costimulatory effects of the TNF receptor superfamily members CD134 (OX40) and CD137 (4-1BB), and their role in the generation of anti-tumor immune responses

1 reference

12 December 2020

A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis

1 reference

12 December 2020

Involvement of inducible costimulator in the exaggerated memory B cell and plasma cell generation in systemic lupus erythematosus

1 reference

12 December 2020

Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis

1 reference

12 December 2020

5-Methylcytosine content of DNA in blood, synovial mononuclear cells and synovial tissue from patients affected by autoimmune rheumatic diseases

1 reference

12 December 2020

CD27 is a signal-transducing molecule involved in CD45RA+ naive T cell costimulation

1 reference

12 December 2020

Identifiers

DOI

10.1155/2013/245928

1 reference

18 August 2017

1 reference

18 August 2017

1 reference

PMCID

3755444