Molecular dynamics suggest multifunctionality of an adenine imino group in acid-base catalysis of the hairpin ribozyme. (Q37142097)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19223444%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

title

Molecular dynamics suggest multifunctionality of an adenine imino group in acid-base catalysis of the hairpin ribozyme (English)

1 reference

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21 January 2020

0 references

0 references

1

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21 January 2020

Jirí Sponer

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19223444%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Nils G Walter

3

1 reference

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21 January 2020

author name string

Mark A Ditzler

1

1 reference

18 August 2017

Jirí Sponer

2

1 reference

18 August 2017

Nils G Walter

3

1 reference

18 August 2017

language of work or name

English

0 references

publication date

17 February 2009

1 reference

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21 January 2020

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21 January 2020

volume

15

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21 January 2020

issue

4

1 reference

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21 January 2020

page(s)

560-575

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describes a project that uses

21 January 2020

ImageQuant

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11 June 2022

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inferred from PubMed Central ID database lookup

cites work

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Structural effects of nucleobase variations at key active site residue Ade38 in the hairpin ribozyme

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Electrostatic interactions in the hairpin ribozyme account for the majority of the rate acceleration without chemical participation by nucleobases

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Structural roles of monovalent cations in the HDV ribozyme

6 September 2017

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The genomic HDV ribozyme utilizes a previously unnoticed U-turn motif to accomplish fast site-specific catalysis

6 September 2017

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The QM/MM molecular dynamics and free energy simulations of the acylation reaction catalyzed by the serine-carboxyl peptidase kumamolisin-As

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Structural investigation of the GlmS ribozyme bound to Its catalytic cofactor

6 September 2017

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Active site labeling of G8 in the hairpin ribozyme: implications for structure and mechanism

6 September 2017

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Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease

6 September 2017

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6 September 2017

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Structural basis of glmS ribozyme activation by glucosamine-6-phosphate

6 September 2017

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Trapped water molecules are essential to structural dynamics and function of a ribozyme

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Water in the active site of an all-RNA hairpin ribozyme and effects of Gua8 base variants on the geometry of phosphoryl transfer

6 September 2017

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The tRNase Z family of proteins: physiological functions, substrate specificity and structural properties

6 September 2017

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Conformational heterogeneity at position U37 of an all-RNA hairpin ribozyme with implications for metal binding and the catalytic structure of the S-turn

6 September 2017

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Structural evidence for a two-metal-ion mechanism of group I intron splicing

6 September 2017

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The catalytic diversity of RNAs

6 September 2017

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Role of an active site adenine in hairpin ribozyme catalysis

6 September 2017

1 reference

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Ribozyme catalysis: not different, just worse

6 September 2017

1 reference

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Single-molecule enzymology of RNA: essential functional groups impact catalysis from a distance

6 September 2017

1 reference

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Simulation and modeling of nucleic acid structure, dynamics and interactions

6 September 2017

1 reference

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Control of gene expression by a natural metabolite-responsive ribozyme

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2661834

Crystallographic and biochemical investigations of kumamolisin-As, a serine-carboxyl peptidase with collagenase activity.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2661834

Single-molecule transition-state analysis of RNA folding

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2661834

Mechanistic considerations for general acid-base catalysis by RNA: revisiting the mechanism of the hairpin ribozyme

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2661834

Transition state stabilization by a catalytic RNA

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2661834

Comparative analysis of hairpin ribozyme structures and interference data

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2661834

Functional involvement of G8 in the hairpin ribozyme cleavage mechanism

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2661834

Investigation of adenosine base ionization in the hairpin ribozyme by nucleotide analog interference mapping

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2661834

Crystal structure of a hairpin ribozyme-inhibitor complex with implications for catalysis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2661834

Relationship between internucleotide linkage geometry and the stability of RNA.

6 September 2017

1 reference

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The hammerhead, hairpin and VS ribozymes are catalytically proficient in monovalent cations alone

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2661834

Essential nucleotide sequences and secondary structure elements of the hairpin ribozyme

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2661834

Dissection of the role of the conserved G.U pair in group I RNA self-splicing

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2661834

Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2661834

The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2661834

Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2661834

Nucleobase catalysis in the hairpin ribozyme

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2661834

Structure, dynamics, and elasticity of free 16s rRNA helix 44 studied by molecular dynamics simulations

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2661834

Rescue of an abasic hairpin ribozyme by cationic nucleobases: evidence for a novel mechanism of RNA catalysis

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2661834

Molecular Dynamics and Free Energy Study of the Conformational Equilibria in the UUUU RNA Hairpin

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2661834

Functional analysis of hairpin ribozyme active site architecture

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2661834

Impact of an extruded nucleotide on cleavage activity and dynamic catalytic core conformation of the hepatitis delta virus ribozyme.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2661834

Calculation of pKas in RNA: on the structural origins and functional roles of protonated nucleotides.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2661834

Structural dynamics of precursor and product of the RNA enzyme from the hepatitis delta virus as revealed by molecular dynamics simulations

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2661834

Role of an active site guanine in hairpin ribozyme catalysis probed by exogenous nucleobase rescue

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2661834

A conformational switch controls hepatitis delta virus ribozyme catalysis

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2661834

Significant kinetic solvent isotope effects in folding of the catalytic RNA from the hepatitis delta virus

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2661834

Probing non-selective cation binding in the hairpin ribozyme with Tb(III).

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2661834

Nucleophilic attack on phosphate diesters: a density functional study of in-line reactivity in dianionic, monoanionic, and neutral systems

3 September 2018

1 reference

12 December 2020

A modified version of the Cornell et al. force field with improved sugar pucker phases and helical repeat

1 reference

12 December 2020

A unique mechanism for RNA catalysis: the role of metal cofactors in hairpin ribozyme cleavage

1 reference

12 December 2020

A conformational change in the "loop E-like" motif of the hairpin ribozyme is coincidental with domain docking and is essential for catalysis

1 reference

12 December 2020

Optimization of an anti-HIV hairpin ribozyme by in vitro selection

1 reference

12 December 2020

Identifiers

DOI

10.1261/RNA.1416709

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19223444%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19223444%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference