Mechanism of synergistic activation of Arp2/3 complex by cortactin and N-WASP (Q37145133)

18 August 2017

Mechanism of synergistic activation of Arp2/3 complex by cortactin and N-WASP (English)

1 reference

18 August 2017

Luke A Helgeson

1

1 reference

18 August 2017

Brad J Nolen

series ordinal

2

1 reference

18 August 2017

language of work or name

English

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publication date

3 September 2013

1 reference

18 August 2017

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18 August 2017

2

1 reference

18 August 2017

e00884

1 reference

describes a project that uses

18 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3762189/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Arp2/3 complex is bound and activated by two WASP proteins

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GMF is a cofilin homolog that binds Arp2/3 complex to stimulate filament debranching and inhibit actin nucleation

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Actin, a central player in cell shape and movement

6 September 2017

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N-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cells

6 September 2017

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The actin-binding domain of cortactin is dynamic and unstructured and affects lateral and longitudinal contacts in F-actin

6 September 2017

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Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia

6 September 2017

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6 September 2017

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Capping protein increases the rate of actin-based motility by promoting filament nucleation by the Arp2/3 complex

6 September 2017

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Arp2/3 complex interactions and actin network turnover in lamellipodia.

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Cortactin binding to F-actin revealed by electron microscopy and 3D reconstruction

6 September 2017

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Actin binding to the central domain of WASP/Scar proteins plays a critical role in the activation of the Arp2/3 complex

6 September 2017

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6 September 2017

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6 September 2017

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Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin

6 September 2017

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Cortactin regulates cell migration through activation of N-WASP

6 September 2017

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Real-time measurements of actin filament polymerization by total internal reflection fluorescence microscopy

6 September 2017

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6 September 2017

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Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP

6 September 2017

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Sequential interaction of actin-related proteins 2 and 3 (Arp2/3) complex with neural Wiscott-Aldrich syndrome protein (N-WASP) and cortactin during branched actin filament network formation

6 September 2017

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Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion

6 September 2017

1 reference

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Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation

6 September 2017

1 reference

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Activation of Arp2/3 complex-mediated actin polymerization by cortactin

6 September 2017

1 reference

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Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex

6 September 2017

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Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex

6 September 2017

1 reference

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Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex

6 September 2017

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The kinetic mechanism of myosin V.

6 September 2017

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Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex

6 September 2017

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Pak1 phosphorylation enhances cortactin-N-WASP interaction in clathrin-caveolin-independent endocytosis

6 September 2017

1 reference

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Cortactin promotes cell motility by enhancing lamellipodial persistence

14 September 2017

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Mechanism of actin network attachment to moving membranes: barbed end capture by N-WASP WH2 domains

14 September 2017

1 reference

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Rate constants for the reactions of ATP- and ADP-actin with the ends of actin filaments

27 June 2018

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Cortactin releases the brakes in actin- based motility by enhancing WASP-VCA detachment from Arp2/3 branches.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3762189

A "primer"-based mechanism underlies branched actin filament network formation and motility

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3762189

On the mechanism of Trolox as antiblinking and antibleaching reagent

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3762189

Pathway of actin filament branch formation by Arp2/3 complex.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3762189

Interaction of cortactin and N-WASp with Arp2/3 complex

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3762189

Interactions of ADF/cofilin, Arp2/3 complex, capping protein and profilin in remodeling of branched actin filament networks

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3762189

An exact mathematical expression for describing competitive binding of two different ligands to a protein molecule.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3762189

Rate of binding of tropomyosin to actin filaments

3 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24015358

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.7554/ELIFE.00884

1 reference

18 August 2017

1 reference

18 August 2017

PubMed publication ID

24015358

1 reference