Ascomycin and FK506: pharmacology and therapeutic potential as anticonvulsants and neuroprotectants (Q37164694)

18 August 2017

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title

Ascomycin and FK506: pharmacology and therapeutic potential as anticonvulsants and neuroprotectants (English)

1 reference

18 August 2017

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Germán Sierra-Paredes

series ordinal

1

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PubMed ID

18482098

18 August 2017

Germán Sierra-Marcuño

series ordinal

2

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18 August 2017

1 January 2008

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CNS Neuroscience & Therapeutics

18 August 2017

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18 August 2017

14

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18 August 2017

1

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18 August 2017

36-46

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Systemic toxicity of tacrolimus given by various routes and the response to dose reduction

18 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Involvement of phosphatase activities in the run-down of GABA(A) receptor function in rat cerebellar granule cells in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Calcium channel regulation by calcineurin, a Ca2+-activated phosphatase in mammalian brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Macrolactam immunomodulators for topical treatment of inflammatory skin diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

A modulatory role for protein phosphatase 2B (calcineurin) in the regulation of Ca2+ entry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Intracellular calcium homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

The mitochondrial permeability transition pore and its role in cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Pathobiology of ischaemic stroke: an integrated view

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Calcineurin anchoring and cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

FK506, an immunosuppressant targeting calcineurin function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Expression of the inducible form of nitric oxide synthase by reactive astrocytes after transient global ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

FK506 and the role of immunophilins in nerve regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Dephosphorylation of microtubule-associated protein 2, tau factor, and tubulin by calcineurin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Calcineurin regulation of neuronal plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Factors affecting the pharmacokinetics of tacrolimus (FK506) in hematopoietic cell transplant (HCT) patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Molecular mechanisms of neuroprotective action of immunosuppressants--facts and hypotheses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Brain-derived neurotrophic factor prevents neuronal death and glial activation after global ischemia in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Regulation of the calmodulin-stimulated protein phosphatase, calcineurin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

A significant increase in both basal and maximal calcineurin activity following fluid percussion injury in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

A significant increase in both basal and maximal calcineurin activity in the rat pilocarpine model of status epilepticus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Pharmacokinetics of tacrolimus after multidose oral administration and efficacy in the prevention of allograft rejection in cats with renal transplants

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Regulation of NMDA channel function by endogenous Ca(2+)-dependent phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Mitochondrial targeted cyclophilin D protects cells from cell death by peptidyl prolyl isomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Calcineurin-mediated LTD of GABAergic inhibition underlies the increased excitability of CA1 neurons associated with LTP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

21 January 2018

GABAA receptor channels

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Chemokines and their receptors in the brain: pathophysiological roles in ischemic brain injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Regulation of ion channel localization and phosphorylation by neuronal activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Immunosupressants and calcineurin inhibitors, cyclosporin A and FK506, reversibly inhibit epileptogenesis in amygdaloid kindled rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Characterization of microglial reaction after middle cerebral artery occlusion in rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

On-chip micro-flow polystyrene bead-based immunoassay for quantitative detection of tacrolimus (FK506).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Cyclosporin A limits calcium-induced axonal damage following traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

In vitro status epilepticus causes sustained elevation of intracellular calcium levels in hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

A multifunctional calmodulin-stimulated phosphatase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Tacrolimus clearance is age-dependent within the pediatric population

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Cyclosporin A-sensitive signaling pathway involving calcineurin regulates survival of reactive astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

The immunosuppressant FK506 uncovers a positive regulatory cross-talk between the Hog1p and Gcn2p pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

AMPA/kainate receptor-mediated downregulation of GABAergic synaptic transmission by calcineurin after seizures in the developing rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Protection provided by cyclosporin A against excitotoxic neuronal death is genotype dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Tacrolimus: a further update of its use in the management of organ transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Activity-dependent induction of tonic calcineurin activity mediates a rapid developmental downregulation of NMDA receptor currents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Protective effect of FK506 (tacrolimus) in pentylenetetrazol-induced kindling in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

The immunophilin ligand FK506 attenuates axonal injury in an impact-acceleration model of traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Neural actions of immunophilin ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

FK506 facilitates chemical kindling induced by pentylenetetrazole in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Amelioration by cyclosporin A of brain damage in transient forebrain ischemia in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Anticonvulsant effect of the calcineurin inhibitor ascomycin on seizures induced by picrotoxin microperfusion in the rat hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Brain inflammation in epilepsy: experimental and clinical evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Presynaptic modulation of cortical synaptic activity by calcineurin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

In vitro metabolism of FK-506 in rat, rabbit, and human liver microsomes: identification of a major metabolite and of cytochrome P450 3A as the major enzymes responsible for its metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Dose-dependent, protective effect of FK506 against white matter changes in the rat brain after chronic cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Inhibition of the mitochondrial permeability transition by the nonimmunosuppressive cyclosporin derivative NIM811.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Expression of interleukin-1 alpha, tumor necrosis factor alpha and interleukin-6 genes in astrocytes under ischemic injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

A novel mechanism of FK506-mediated neuroprotection: downregulation of cytokine expression in glial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Current and Future Therapeutic Strategies to Target Inflammation in Stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Perspectives on the mitochondrial permeability transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-5949.2008.00036.X

Regulation of the γ-aminobutyric acid transporter activity by protein phosphatases in synaptic plasma membranes

21 January 2018

1 reference

12 December 2020

Glutamate-induced neuron death requires mitochondrial calcium uptake

1 reference

12 December 2020

Immunophilin FK506-binding protein 52 (not FK506-binding protein 12) mediates the neurotrophic action of FK506.

1 reference

12 December 2020

If phosphatases go up, memory goes down

1 reference

12 December 2020

High level calcineurin activity predisposes neuronal cells to apoptosis

1 reference

12 December 2020

Mitochondria and neuronal survival

1 reference

12 December 2020

Tacrolimus: a further update of its pharmacology and therapeutic use in the management of organ transplantation

1 reference

12 December 2020

Pilocarpine-induced status epilepticus causes N-methyl-D-aspartate receptor-dependent inhibition of microsomal Mg(2+)/Ca(2+) ATPase-mediated Ca(2+) uptake

1 reference

12 December 2020

Fas (CD95/APO-1) plays a role in the pathophysiology of focal cerebral ischemia

1 reference

12 December 2020

Calcineurin-mediated BAD dephosphorylation activates the caspase-3 apoptotic cascade in traumatic spinal cord injury

1 reference

12 December 2020

Attenuation and augmentation of ischaemia-related neuronal death by tumour necrosis factor-alpha in vitro

1 reference

12 December 2020

Ascomycin: an advance in the management of atopic dermatitis

1 reference

12 December 2020

Therapeutic neutralization of CD95-ligand and TNF attenuates brain damage in stroke

1 reference

12 December 2020

FK506 attenuates early ischemic neuronal death in a monkey model of stroke

1 reference

12 December 2020

In vitro hypoxia and excitotoxicity in human brain induce calcineurin-Bcl-2 interactions

1 reference

12 December 2020

Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat

1 reference

12 December 2020

Ascomycin, an antifungal antibiotic

1 reference

12 December 2020

Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses

1 reference

12 December 2020

An astrocytic basis of epilepsy

1 reference

12 December 2020

The immunosuppressant FK506 increases functional recovery and nerve regeneration following peripheral nerve injury

1 reference

12 December 2020

FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro

1 reference

12 December 2020

Tacrolimus. A review of its pharmacology, and therapeutic potential in hepatic and renal transplantation

1 reference

12 December 2020

Pharmacokinetics of FK506 after intravenous and oral administration in patients awaiting renal transplantation

1 reference

12 December 2020

Suppression of GABAA receptor responses by NMDA application in hippocampal neurones acutely isolated from the adult guinea-pig

1 reference

12 December 2020

Synaptic desensitization of NMDA receptors by calcineurin

1 reference

12 December 2020

Mechanisms of secondary brain damage in global and focal ischemia: a speculative synthesis

1 reference

12 December 2020

Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability

1 reference

12 December 2020

Mitochondrial dysfunction is a primary event in glutamate neurotoxicity

1 reference

12 December 2020

Calcineurin modulates G protein-mediated inhibition of N-type calcium channels in rat sympathetic neurons

1 reference

12 December 2020

Discovery of less nephrotoxic FK506 analogs and determining immunophilin dependence of immunosuppressant nephrotoxicity with a novel single-dose rat cisplatin potentiation assay

1 reference

12 December 2020

Tacrolimus. An update of its pharmacology and clinical efficacy in the management of organ transplantation

1 reference

12 December 2020

Decreased expression of calmodulin kinase II and calcineurin messenger RNAs in the mouse hippocampus after kainic acid-induced seizures.

1 reference

12 December 2020

Cyclosporin A, but not FK 506, protects mitochondria and neurons against hypoglycemic damage and implicates the mitochondrial permeability transition in cell death.

1 reference

12 December 2020

Maintenance of recombinant type A gamma-aminobutyric acid receptor function: role of protein tyrosine phosphorylation and calcineurin.

1 reference

12 December 2020

Relationship between in vivo FK506 clearance and in vitro 13-demethylation activity in living-related liver transplantation

1 reference

12 December 2020

Regulation of F-actin stability in dendritic spines by glutamate receptors and calcineurin.

1 reference

12 December 2020

Altered patterns of Ca2+/calmodulin-dependent protein kinase II and calcineurin immunoreactivity in the hippocampus of patients with temporal lobe epilepsy.

1 reference

12 December 2020

Cytokine actions in the central nervous system

1 reference

12 December 2020

Calcineurin inhibitors FK506 and SDZ ASM 981 alleviate the outcome of focal cerebral ischemic/reperfusion injury.

1 reference

12 December 2020

10.1111/J.1755-5949.2008.00036.X

Identifiers

DOI

1 reference

release_hzdnu6gebzeoxcv6n2a5kuaxci

18 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/hzdnu6gebzeoxcv6n2a5kuaxci

24 November 2022

mapped directly with Wikidata item

PubMed ID

18482098

1 reference

PubMed ID

18482098