Tumour-stroma interactions in colorectal cancer: converging on beta-catenin activation and cancer stemness (Q37174369)

18 August 2017

1 reference

25 September 2020

Tumour-stroma interactions in colorectal cancer: converging on beta-catenin activation and cancer stemness (English)

1 reference

18 August 2017

5 references

12 October 2019

20 November 2019

11 December 2019

22 December 2019

25 September 2020

neoplastic stem cells

1 reference

12 October 2019

1 reference

25 September 2020

1 reference

1 reference

R Fodde

3

0 references

author name string

N H Le

series ordinal

1

1 reference

18 August 2017

P Franken

series ordinal

2

1 reference

18 August 2017

language of work or name

English

0 references

publication date

27 May 2008

1 reference

British Journal of Cancer

18 August 2017

17 June 2008

7 references

21 March 2019

3 April 2019

12 October 2019

20 November 2019

11 December 2019

22 December 2019

25 September 2020

8 references

18 August 2017

21 March 2019

3 April 2019

12 October 2019

20 November 2019

11 December 2019

22 December 2019

25 September 2020

98

1 reference

18 August 2017

12

1 reference

18 August 2017

1886-1893

1 reference

https://scigraph.springernature.com/pub.10.1038/sj.bjc.6604401

18 August 2017

0 references

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6 September 2017

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TGF-beta receptor 2 downregulation in tumour-associated stroma worsens prognosis and high-grade tumours show more tumour-associated macrophages and lower TGF-beta1 expression in colon carcinoma: a retrospective study

6 September 2017

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6 September 2017

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Hypoxia-driven selection of the metastatic phenotype

6 September 2017

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Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation

6 September 2017

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6 September 2017

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Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia

6 September 2017

1 reference

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CD4+CD25+FOXP3+ regulatory T cells suppress anti-tumor immune responses in patients with colorectal cancer

6 September 2017

1 reference

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Adipocytes and preadipocytes promote the proliferation of colon cancer cells in vitro.

6 September 2017

1 reference

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Targeting the expression of platelet-derived growth factor receptor by reactive stroma inhibits growth and metastasis of human colon carcinoma.

6 September 2017

1 reference

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Type, density, and location of immune cells within human colorectal tumors predict clinical outcome

6 September 2017

1 reference

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Improving antitumor immune responses by circumventing immunoregulatory cells and mechanisms

6 September 2017

1 reference

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Stromal fibroblasts in cancer: a novel tumor-promoting cell type

6 September 2017

1 reference

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Organizing cell renewal in the intestine: stem cells, signals and combinatorial control

6 September 2017

1 reference

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6 September 2017

Fibroblasts in cancer

1 reference

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Paradoxical roles of the immune system during cancer development

6 September 2017

1 reference

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Effector memory T cells, early metastasis, and survival in colorectal cancer

6 September 2017

1 reference

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VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

6 September 2017

1 reference

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Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression

6 September 2017

1 reference

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The role of TGF-beta and Wnt signaling in gastrointestinal stem cells and cancer

6 September 2017

1 reference

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Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441948

Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441948

Functional interaction between beta-catenin and FOXO in oxidative stress signaling

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441948

Wnt signalling induces maturation of Paneth cells in intestinal crypts

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441948

Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis

6 September 2017

1 reference

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Immune regulation in the intestine: a balancing act between effector and regulatory T cell responses

6 September 2017

1 reference

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The stroma reaction myofibroblast: a key player in the control of tumor cell behavior

6 September 2017

1 reference

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APC dosage effects in tumorigenesis and stem cell differentiation

6 September 2017

1 reference

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IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

6 September 2017

1 reference

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TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441948

Smad4 and β-Catenin Co-activators Functionally Interact with Lymphoid-enhancing Factor to Regulate Graded Expression of Msx2

6 September 2017

1 reference

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The myofibroblast in wound healing and fibrocontractive diseases

6 September 2017

1 reference

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Role of tissue stroma in cancer cell invasion

6 September 2017

1 reference

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Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes

6 September 2017

1 reference

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APC, signal transduction and genetic instability in colorectal cancer

6 September 2017

1 reference

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Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441948

Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441948

Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441948

Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441948

The host inflammatory response promotes liver metastasis by increasing tumor cell arrest and extravasation.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441948

PDGF essentially links TGF-beta signaling to nuclear beta-catenin accumulation in hepatocellular carcinoma progression.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441948

A novel DNA vaccine encoding PDGFRbeta suppresses growth and dissemination of murine colon, lung and breast carcinoma

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441948

P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from beta-catenin

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441948

Expression of activated platelet-derived growth factor receptor in stromal cells of human colon carcinomas is associated with metastatic potential.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441948

Interaction between the transforming growth factor-beta type II receptor/Smad pathway and beta-catenin during transforming growth factor-beta1-mediated adherens junction disassembly

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441948

Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441948

Proliferating fibroblasts at the invading tumour edge of colorectal adenocarcinomas are associated with endogenous markers of hypoxia, acidity, and oxidative stress

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441948

Stromal expression of hypoxia regulated proteins is an adverse prognostic factor in colorectal carcinomas.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441948

Increased frequency of regulatory T cells in peripheral blood and tumour infiltrating lymphocytes in colorectal cancer patients.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441948

Physical and functional cooperation between AP-1 and beta-catenin for the regulation of TCF-dependent genes.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441948

Smad4 signalling in T cells is required for suppression of gastrointestinal cancer.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441948

Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441948

Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441948

Mutual paracrine effects of colorectal tumour cells and stromal cells: modulation of tumour and stromal cell differentiation and extracellular matrix component production in culture.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441948

Smad1, beta-catenin and Tcf4 associate in a molecular complex with the Myc promoter in dysplastic renal tissue and cooperate to control Myc transcription.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441948

Immunohistochemical study of myofibroblasts in normal colonic mucosa, hyperplastic polyps, and adenomatous colorectal polyps.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441948

Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441948

A positive feedback loop between hepatocyte growth factor receptor and β-catenin sustains colorectal cancer cell invasive growth

3 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.BJC.6604401

Smad7-induced beta-catenin degradation alters epidermal appendage development

21 January 2018

1 reference

12 December 2020

The metastasis-associated gene S100A4 is a novel target of beta-catenin/T-cell factor signaling in colon cancer

1 reference

12 December 2020

SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion

1 reference

12 December 2020

MUTYH-null mice are susceptible to spontaneous and oxidative stress induced intestinal tumorigenesis

1 reference

12 December 2020

Synergistic activation of the murine gastrin promoter by oncogenic Ras and beta-catenin involves SMAD recruitment

1 reference

12 December 2020

Identifiers

DOI

10.1038/SJ.BJC.6604401

1 reference

18 August 2017

1 reference

18 August 2017

1 reference