APC, signal transduction and genetic instability in colorectal cancer (Q34568154)

3 August 2017

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title

APC, signal transduction and genetic instability in colorectal cancer (English)

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3 August 2017

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Fodde R

1

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3 August 2017

Smits R

series ordinal

2

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3 August 2017

Clevers H

series ordinal

3

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3 August 2017

language of work or name

English

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publication date

1 October 2001

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3 August 2017

Nature Reviews Cancer

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3 August 2017

1

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3 August 2017

55-67

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3 August 2017

1

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https://scigraph.springernature.com/pub.10.1038/35094067

3 August 2017

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cites work

Lessons from hereditary colorectal cancer

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7 January 2021

APC mutations occur early during colorectal tumorigenesis

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7 January 2021

Mutations in the APC tumour suppressor gene cause chromosomal instability

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7 January 2021

A role for the Adenomatous Polyposis Coli protein in chromosome segregation

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7 January 2021

How many mutations does it take to make a tumor?

1 reference

7 January 2021

Selection, the mutation rate and cancer: Ensuring that the tail does not wag the dog

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7 January 2021

Cancer statistics, 2000.

1 reference

7 January 2021

Estimates of the worldwide mortality from 25 cancers in 1990.

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7 January 2021

A genetic model for colorectal tumorigenesis

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7 January 2021

Loss of constitutional heterozygosity in colon carcinoma from patients with familial polyposis coli.

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7 January 2021

Chromosome 5 allele loss in human colorectal carcinomas.

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7 January 2021

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

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7 January 2021

Prevalence of ras gene mutations in human colorectal cancers

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7 January 2021

Genetic alterations during colorectal-tumor development

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7 January 2021

K-ras mutations in putative preneoplastic lesions in human colon

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7 January 2021

Clonal analysis of human colorectal tumors

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7 January 2021

Concerted nonsyntenic allelic loss in human colorectal carcinoma

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7 January 2021

Allelotype of colorectal carcinomas

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7 January 2021

p53 mutations in colorectal cancer

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7 January 2021

Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas

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7 January 2021

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

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7 January 2021

Role of transforming growth factor beta in human disease

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7 January 2021

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

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7 January 2021

MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

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7 January 2021

Disease model: familial adenomatous polyposis

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7 January 2021

Genetic instability of cancer cells is proportional to their degree of aneuploidy

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7 January 2021

How aneuploidy affects metabolic control and causes cancer

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7 January 2021

Genetic instabilities in human cancers

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7 January 2021

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

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7 January 2021

Microsatellite instability in cancer of the proximal colon

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7 January 2021

Hypermutability and mismatch repair deficiency in RER+ tumor cells

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7 January 2021

Mutator phenotypes in human colorectal carcinoma cell lines

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7 January 2021

Genetic instability in colorectal cancers

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7 January 2021

Mechanisms underlying losses of heterozygosity in human colorectal cancers

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7 January 2021

Mutations of mitotic checkpoint genes in human cancers

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7 January 2021

Abnormal centrosome amplification in the absence of p53.

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7 January 2021

Cytogenetic comparisons of synchronous carcinomas and polyps in patients with colorectal cancer

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7 January 2021

Genetic instability and darwinian selection in tumours

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7 January 2021

The onset and extent of genomic instability in sporadic colorectal tumor progression

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7 January 2021

Identification and characterization of the familial adenomatous polyposis coli gene

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7 January 2021

Identification of FAP locus genes from chromosome 5q21

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7 January 2021

Mutations of the APC (adenomatous polyposis coli) gene

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7 January 2021

Association of the APC tumor suppressor protein with catenins

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7 January 2021

Association of the APC gene product with beta-catenin

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7 January 2021

Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta

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7 January 2021

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta

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7 January 2021

Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization

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7 January 2021

Axin prevents Wnt-3a-induced accumulation of beta-catenin

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7 January 2021

GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin

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7 January 2021

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

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7 January 2021

beta-TrCP is a negative regulator of Wnt/beta-catenin signaling pathway and dorsal axis formation in Xenopus embryos.

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7 January 2021

A new member of the frizzled family from Drosophila functions as a Wingless receptor

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7 January 2021

Functional interaction of beta-catenin with the transcription factor LEF-1

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7 January 2021

XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos

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7 January 2021

The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors

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7 January 2021

Drosophila Tcf and Groucho interact to repress Wingless signalling activity.

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7 January 2021

The APC tumour suppressor has a nuclear export function.

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7 January 2021

Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover

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7 January 2021

Nuclear export of human beta-catenin can occur independent of CRM1 and the adenomatous polyposis coli tumor suppressor

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7 January 2021

Differential molecular interactions of beta-catenin and plakoglobin in adhesion, signaling and cancer

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7 January 2021

Adenomatous polyposis coli (APC) protein moves along microtubules and concentrates at their growing ends in epithelial cells

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7 January 2021

The dynamic behavior of the APC-binding protein EB1 on the distal ends of microtubules

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7 January 2021

The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.

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7 January 2021

A domain within the tumor suppressor protein APC shows very similar biochemical properties as the microtubule-associated protein tau.

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7 January 2021

Regulation and function of the interaction between the APC tumour suppressor protein and EB1

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7 January 2021

EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability

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7 January 2021

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

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7 January 2021

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

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7 January 2021

Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development

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7 January 2021

Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling

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7 January 2021

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

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7 January 2021

Axin and hepatocellular carcinomas.

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7 January 2021

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

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7 January 2021

The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis

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7 January 2021

APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits"

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7 January 2021

Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity

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7 January 2021

Overexpression of beta-catenin induces apoptosis independent of its transactivation function with LEF-1 or the involvement of major G1 cell cycle regulators

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7 January 2021

Identification of c-MYC as a target of the APC pathway

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7 January 2021

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

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7 January 2021

The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway

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7 January 2021

Immunohistochemical study of epithelial cell proliferation in hyperplastic polyps, adenomas, and adenocarcinomas of the large bowel

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7 January 2021

Proliferation and apoptosis in proliferative lesions of the colon and rectum

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7 January 2021

Immunohistochemical analysis of cell kinetic parameters in colonic adenocarcinomas, adenomas, and normal mucosa

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7 January 2021

The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors

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7 January 2021

beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer

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7 January 2021

Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway

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7 January 2021

Expression of nuclear beta-catenin and c-myc is correlated with tumor size but not with proliferative activity of colorectal adenomas

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7 January 2021

Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas

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7 January 2021

The APC gene product in normal and tumor cells

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7 January 2021

APC expression in normal human tissues

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7 January 2021

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

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7 January 2021

Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium

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7 January 2021

Oncogene expression in patients with familial polyposis coli/Gardner's syndrome

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7 January 2021

Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1.

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7 January 2021

Top-down morphogenesis of colorectal tumors

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7 January 2021

The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system

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7 January 2021

Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene

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7 January 2021

The centrosome--a tiny organelle with big potential

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7 January 2021

ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage

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7 January 2021

Reciprocity between membranous and nuclear expression of beta-catenin in colorectal tumours

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7 January 2021

Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front.

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7 January 2021

E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice

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7 January 2021

E-Cadherin Suppresses Cellular Transformation by Inhibiting β-Catenin Signaling in an Adhesion-Independent Manner

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7 January 2021

K-ras-2 G-C and G-T transversions correlate with DNA aneuploidy in colorectal adenomas

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7 January 2021

Transfection of human mutated K-ras in mouse NIH-3T3 cells is associated with increased cloning efficiency and DNA aneuploidization

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7 January 2021

Specific K-ras2 mutations in human sporadic colorectal adenomas are associated with DNA near-diploid aneuploidy and inhibition of proliferation

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7 January 2021

Ki-ras activation in vitro affects G1 and G2M cell-cycle transit times and apoptosis

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7 January 2021

The RAS oncogene induces genomic instability in thyroid PCCL3 cells via the MAPK pathway

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7 January 2021

Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF.

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7 January 2021

Genomic instability and apoptosis are frequent in p53 deficient young mice

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7 January 2021

Defects in transforming growth factor-beta signaling cooperate with a Ras oncogene to cause rapid aneuploidy and malignant transformation of mouse keratinocytes

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7 January 2021

C-myc overexpression and p53 loss cooperate to promote genomic instability

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7 January 2021

c-Myc overexpression uncouples DNA replication from mitosis

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7 January 2021

Chromosome instability contributes to loss of heterozygosity in mice lacking p53

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7 January 2021

Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents.

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7 January 2021

Mismatch repair, molecular switches, and signal transduction.

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7 January 2021

Signaling mismatch repair in cancer

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7 January 2021

BRCA1 and cell signaling

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7 January 2021

Chromosome number and structure both are markedly stable in RER colorectal cancers and are not destabilized by mutation of p53

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7 January 2021

Cancer-susceptibility genes. Gatekeepers and caretakers

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7 January 2021

Role of aberrant crypt foci in understanding the pathogenesis of colon cancer

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7 January 2021

Aberrant crypt foci of the colon as precursors of adenoma and cancer

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7 January 2021

Mutations in the SMAD4/DPC4 gene in juvenile polyposis

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7 January 2021

Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis.

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7 January 2021

Smad3 mutant mice develop metastatic colorectal cancer

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7 January 2021

Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice.

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7 January 2021

Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes

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7 January 2021

Serrated route to colorectal cancer: back street or super highway?

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7 January 2021

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

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7 January 2021

How cells read TGF-beta signals

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7 January 2021

Identifiers

DOI

10.1038/35094067

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Dimensions Publication ID

3 August 2017

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