Oxidative stress and the pathogenesis of scleroderma: the Murrell's hypothesis revisited (Q37189391)

18 August 2017

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title

Oxidative stress and the pathogenesis of scleroderma: the Murrell's hypothesis revisited (English)

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18 August 2017

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Armando Gabrielli

1

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18 August 2017

Silvia Svegliati

2

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18 August 2017

Gianluca Moroncini

3

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18 August 2017

Giovanni Pomponio

4

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18 August 2017

Mariarosaria Santillo

5

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18 August 2017

Enrico V Avvedimento

6

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18 August 2017

publication date

12 June 2008

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Seminars in Immunopathology

18 August 2017

published in

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18 August 2017

volume

30

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18 August 2017

issue

3

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18 August 2017

page(s)

329-337

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Following the molecular pathways toward an understanding of the pathogenesis of systemic sclerosis

18 August 2017

cites work

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https://api.crossref.org/works/10.1007%2FS00281-008-0125-4

Gp91phox contributes to NADPH oxidase activity in aortic fibroblasts but not smooth muscle cells

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Oxidative stress promotes polarization of human T cell differentiation toward a T helper 2 phenotype

21 January 2018

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Capillary alterations in scleroderma

21 January 2018

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NAD(P)H oxidase: role in cardiovascular biology and disease

21 January 2018

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Modulation of fibroblast proliferation by oxygen free radicals

21 January 2018

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Reactive oxygen and nitrogen intermediates increase transforming growth factor-beta1 release from human epithelial alveolar cells through two different mechanisms

21 January 2018

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Transforming growth factor-beta1 is a potent inhibitor of glutathione synthesis in the lung epithelial cell line A549: transcriptional effect on the GSH rate-limiting enzyme gamma-glutamylcysteine synthetase

21 January 2018

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Emphysematous lesions, inflammation, and fibrosis in the lungs of transgenic mice overexpressing platelet-derived growth factor

21 January 2018

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Distinct PKC isoforms mediate cell survival and DNA synthesis in thrombin-induced myofibroblasts.

21 January 2018

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12 December 2020

Beauty and the beast. The nitric oxide paradox in systemic sclerosis

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12 December 2020

Monocytes of patients wiht systemic sclerosis (scleroderma spontaneously release in vitro increased amounts of superoxide anion

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12 December 2020

Expression of platelet-derived growth factor B-chain and platelet-derived growth factor beta-receptor in fibroblasts of scleroderma.

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12 December 2020

Defective vasculogenesis in systemic sclerosis

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12 December 2020

Levels of F2-isoprostanes in systemic sclerosis: correlation with clinical features

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12 December 2020

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide

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12 December 2020

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

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12 December 2020

Lipid peroxidation and trace elements in systemic sclerosis

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12 December 2020

Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition

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12 December 2020

Novel gp91(phox) homologues in vascular smooth muscle cells : nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways

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12 December 2020

Probucol improves symptoms and reduces lipoprotein oxidation susceptibility in patients with Raynaud's phenomenon

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12 December 2020

Evidence of free radical-mediated injury (isoprostane overproduction) in scleroderma

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12 December 2020

Increased production of nitric oxide stimulated by interleukin-1beta in peripheral blood mononuclear cells in patients with systemic sclerosis

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12 December 2020

Decreased nitric oxide in the exhaled air of patients with systemic sclerosis with pulmonary hypertension

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12 December 2020

Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-kappaB2.

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12 December 2020

Thiols decrease human interleukin (IL) 4 production and IL-4-induced immunoglobulin synthesis

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12 December 2020

Low oxygen tension increases mRNA levels of alpha 1 (I) procollagen in human dermal fibroblasts

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12 December 2020

Stimulation of lipid peroxidation or 4-hydroxynonenal treatment increases procollagen alpha 1 (I) gene expression in human liver fat-storing cells

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12 December 2020

Antioxidant status after iloprost treatment in patients with Raynaud's phenomenon secondary to systemic sclerosis.

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12 December 2020

Scleroderma: from cell and molecular mechanisms to disease models

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12 December 2020

Transforming growth factor-beta1 induces Nox4 NAD(P)H oxidase and reactive oxygen species-dependent proliferation in human pulmonary artery smooth muscle cells

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12 December 2020

Sirolimus inhibits platelet-derived growth factor-induced collagen synthesis in rat vascular smooth muscle cells.

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12 December 2020

Autoimmunity in scleroderma: the origin, pathogenetic role, and clinical significance of autoantibodies

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12 December 2020

Nitric oxide production and inducible nitric oxide synthase expression in systemic sclerosis

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12 December 2020

A double-blind placebo-controlled trial of antioxidant therapy in limited cutaneous systemic sclerosis.

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12 December 2020

Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis

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12 December 2020

NADPH oxidase in human lung fibroblasts

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12 December 2020

Thrombin stimulated reactive oxygen species production in cultured human endothelial cells

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12 December 2020

Exhaled nitric oxide in systemic sclerosis: relationships with lung involvement and pulmonary hypertension

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12 December 2020

Important role of Nox4 type NADPH oxidase in angiogenic responses in human microvascular endothelial cells in vitro

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12 December 2020

The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology

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12 December 2020

New concepts in reactive oxygen species and cardiovascular reperfusion physiology

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12 December 2020

Stimulatory Autoantibodies to the PDGF Receptor in Systemic Sclerosis

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12 December 2020

Exhaled nitric oxide is elevated in patients with progressive systemic sclerosis without interstitial lung disease

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12 December 2020

Role of reactive oxygen species in cell signalling pathways

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12 December 2020

Skin capillary changes in early systemic scleroderma. Electron microscopy and "in vitro" autoradiography with tritiated thymidine

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12 December 2020

p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells

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12 December 2020

Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma

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12 December 2020

Sequential dermal microvascular and perivascular changes in the development of scleroderma

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12 December 2020

Abnormal nitric oxide metabolism in systemic sclerosis: increased levels of nitrated proteins and asymmetric dimethylarginine

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12 December 2020

The reactive adventitia: fibroblast oxidase in vascular function

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12 December 2020

Expression of a functionally active gp91phox-containing neutrophil-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: regulation by angiotensin II.

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12 December 2020

Hydrogen peroxide increases interleukin-12 p40/p70 molecular ratio and induces Th2-predominant responses in mice.

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12 December 2020

Redox-mediated activation of latent transforming growth factor-beta 1

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12 December 2020

Reactive oxygen species and antioxidants in inflammatory diseases

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12 December 2020

Dietary intake and nutritional status in patients with systemic sclerosis

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12 December 2020

Platelet-derived growth factor-induced H(2)O(2) production requires the activation of phosphatidylinositol 3-kinase

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12 December 2020

Atrial natriuretic peptide induces mitogen-activated protein kinase phosphatase-1 in human endothelial cells via Rac1 and NAD(P)H oxidase/Nox2-activation

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12 December 2020

Targeting genes for treatment in idiopathic pulmonary fibrosis: challenges and opportunities, promises and pitfalls.

1 reference

12 December 2020

Angiotensin II-induced superoxide anion generation in human vascular endothelial cells: role of membrane-bound NADH-/NADPH-oxidases

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12 December 2020

Elevated serum levels of interleukin 4 (IL-4), IL-10, and IL-13 in patients with systemic sclerosis

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12 December 2020

NAD(P)H oxidases in rat basilar arterial endothelial cells.

1 reference

12 December 2020

Systemic sclerosis: a prototypic multisystem fibrotic disorder

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12 December 2020

Effect of N-acetyl-L-cysteine on peroxynitrite and superoxide anion production of lung alveolar macrophages in systemic sclerosis

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12 December 2020

Serum levels of interleukin 6 (IL-6), oncostatin M, soluble IL-6 receptor, and soluble gp130 in patients with systemic sclerosis

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12 December 2020

NAD(P)H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic reticulum stress and apoptosis in human aortic smooth muscle cells

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12 December 2020

Ets target genes: past, present and future

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12 December 2020

Molecular aspects of scleroderma

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12 December 2020

Serum nitric oxide (NO) levels in systemic sclerosis patients: correlation between NO levels and clinical features

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12 December 2020

Scleroderma autoantigens are uniquely fragmented by metal-catalyzed oxidation reactions: implications for pathogenesis

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12 December 2020

Activation of an H2O2-generating NADH oxidase in human lung fibroblasts by transforming growth factor beta 1.

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12 December 2020

Disruption of redox homeostasis in the transforming growth factor-alpha/c-myc transgenic mouse model of accelerated hepatocarcinogenesis

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12 December 2020

Enhanced in vivo lipid peroxidation in scleroderma spectrum disorders

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12 December 2020

Vascular remodeling in transplant vasculopathy

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12 December 2020

NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts

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12 December 2020

Endothelial expression of nitric oxide synthases and nitrotyrosine in systemic sclerosis skin

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12 December 2020

Intravenous N-acetylcysteine for treatment of Raynaud's phenomenon secondary to systemic sclerosis: a pilot study.

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12 December 2020

Type 2 helper T-cell predominance and high CD30 expression in systemic sclerosis.

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12 December 2020

Reactive oxygen species-sensitive p38 MAPK controls thrombin-induced migration of vascular smooth muscle cells

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12 December 2020

Platelet-derived growth factor-stimulated superoxide anion production modulates activation of transcription factor NF-kappaB and expression of monocyte chemoattractant protein 1 in human aortic smooth muscle cells

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12 December 2020

Postocclusive reactive hyperemia inversely correlates with urinary 15-F2t-isoprostane levels in systemic sclerosis

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12 December 2020

Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis

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12 December 2020

Enhanced production of interleukin-6 (IL-6), oncostatin M and soluble IL-6 receptor by cultured peripheral blood mononuclear cells from patients with systemic sclerosis

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12 December 2020

Nox4 as the major catalytic component of an endothelial NAD(P)H oxidase.

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12 December 2020

Peripheral blood T lymphocytes from systemic sclerosis patients show both Th1 and Th2 activation

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12 December 2020

The role of nitric oxide in inflammation and immunity

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12 December 2020

Increased susceptibility to oxidation of low‐density lipoproteins isolated from patients with systemic sclerosis

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12 December 2020

Increased urinary F2-isoprostanes in systemic sclerosis, but not in primary Raynaud's phenomenon: effect of cold exposure

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12 December 2020

Severity of scleroderma lung disease is related to alveolar concentration of nitric oxide.

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12 December 2020

Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxia-inducible factor 1 via increase in reactive oxygen species

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12 December 2020

Oxidative stress in pulmonary fibrosis: a possible role for redox modulatory therapy

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12 December 2020

Autoantibody against peroxiredoxin I, an antioxidant enzyme, in patients with systemic sclerosis: possible association with oxidative stress

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12 December 2020

Vascular endothelial growth factor (VEGF) and its receptors

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12 December 2020

Vascular abnormalities in scleroderma

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12 December 2020

Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns

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12 December 2020

Oxidative stress in scleroderma: maintenance of scleroderma fibroblast phenotype by the constitutive up-regulation of reactive oxygen species generation through the NADPH oxidase complex pathway

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12 December 2020

Platelet-derived growth factor and reactive oxygen species (ROS) regulate Ras protein levels in primary human fibroblasts via ERK1/2. Amplification of ROS and Ras in systemic sclerosis fibroblasts.

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12 December 2020

NOX3, a superoxide-generating NADPH oxidase of the inner ear

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12 December 2020

A radical proposal for the pathogenesis of scleroderma

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12 December 2020

Micronutrient antioxidant status in patients with primary Raynaud's phenomenon and systemic sclerosis.

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12 December 2020

Nifedipine protects against overproduction of superoxide anion by monocytes from patients with systemic sclerosis

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12 December 2020

Exhaled nitric oxide levels in systemic sclerosis with and without pulmonary involvement.

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12 December 2020

Angiotensin II in the lesional skin of systemic sclerosis patients contributes to tissue fibrosis via angiotensin II type 1 receptors

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12 December 2020

H2O2 activates Nox4 through PLA2-dependent arachidonic acid production in adult cardiac fibroblasts

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12 December 2020

Vitamin E inhibits IL-4 gene expression in peripheral blood T cells

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12 December 2020

Increased expression of platelet-derived growth factor type b receptors in the skin of patients with systemic sclerosis

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12 December 2020

Low levels of nitric oxide (NO) in systemic sclerosis: inducible NO synthase production is decreased in cultured peripheral blood monocyte/macrophage cells

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12 December 2020

10.1007/S00281-008-0125-4

Identifiers

DOI

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18 August 2017

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