Distinct roles of cytochrome P450 reductase in mitomycin C redox cycling and cytotoxicity. (Q37192362)

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3 February 2020

title

Distinct roles of cytochrome P450 reductase in mitomycin C redox cycling and cytotoxicity (English)

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2

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3 February 2020

author name string

Yun Wang

1

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3 February 2020

Vladimir Mishin

3

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Diane E Heck

4

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3 February 2020

Debra L Laskin

5

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3 February 2020

Jeffrey D Laskin

6

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publication date

25 May 2010

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Molecular Cancer Therapeutics

3 February 2020

published in

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volume

9

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issue

6

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3 February 2020

page(s)

1852-1863

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Generation of oxygen deficiency in cell culture using a two-enzyme system to evaluate agents targeting hypoxic tumor cells

3 February 2020

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Overexpression of cytochrome P450 NADPH reductase sensitises MDA 231 breast carcinoma cells to 5-fluorouracil: possible mechanisms involved.

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14 September 2017

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Viral delivery of P450 reductase recapitulates the ability of constitutive overexpression of reductase enzymes to potentiate the activity of mitomycin C in human breast cancer xenografts

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Reversal of mitomycin C resistance by overexpression of bioreductive enzymes in Chinese hamster ovary cells.

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Exploring the mechanistic aspects of mitomycin antibiotic bioactivation in Chinese hamster ovary cells overexpressing NADPH:cytochrome C (P-450) reductase and DT-diaphorase

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Radicals from one-electron reduction of nitro compounds, aromatic N-oxides and quinones: the kinetic basis for hypoxia-selective, bioreductive drugs

28 September 2017

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Increased DT-diaphorase expression and cross-resistance to mitomycin C in a series of cisplatin-resistant human ovarian cancer cell lines

28 September 2017

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Reductase enzyme expression across the National Cancer Institute Tumor cell line panel: correlation with sensitivity to mitomycin C and EO9.

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3 September 2018

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3 September 2018

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3 September 2018

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3 September 2018

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3 September 2018

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Role of NADPH:cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C1.

3 September 2018

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DT-diaphorase as a critical determinant of sensitivity to mitomycin C in human colon and gastric carcinoma cell lines

3 September 2018

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12 December 2020

Reductive activation of mitomycin C by neuronal nitric oxide synthase

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12 December 2020

A stable nonfluorescent derivative of resorufin for the fluorometric determination of trace hydrogen peroxide: applications in detecting the activity of phagocyte NADPH oxidase and other oxidases

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12 December 2020

Enzymology of mitomycin C metabolic activation in tumour tissue: implications for enzyme-directed bioreductive drug development

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12 December 2020

Generation of hydroxyl radical by anticancer quinone drugs, carbazilquinone, mitomycin C, aclacinomycin A and adriamycin, in the presence of NADPH-cytochrome P-450 reductase

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12 December 2020

Reductive activation of mitomycin C and mitomycin C metabolites catalyzed by NADPH-cytochrome P-450 reductase and xanthine oxidase

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12 December 2020

Reactions of the semiquinone free radicals of anti-tumour agents with oxygen and iron complexes

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12 December 2020

Role of glutathione reductase during menadione-induced NADPH oxidation in isolated rat hepatocytes

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12 December 2020

Reductive activation of mitomycin C

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12 December 2020

Bioactivation of mitomycin antibiotics by aerobic and hypoxic Chinese hamster ovary cells overexpressing DT-diaphorase

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12 December 2020

10.1158/1535-7163.MCT-09-1098

Identifiers

DOI

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3 February 2020

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3 February 2020

PubMed publication ID

20501808

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