Hereditary breast cancer: new genetic developments, new therapeutic avenues (Q37199029)

18 August 2017

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title

Hereditary breast cancer: new genetic developments, new therapeutic avenues (English)

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18 August 2017

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Philippe M Campeau

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William David Foulkes

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William D Foulkes

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2

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author name string

Marc D Tischkowitz

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3

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18 August 2017

25 June 2008

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18 August 2017

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18 August 2017

124

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18 August 2017

31-42

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18 August 2017

1

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https://scigraph.springernature.com/pub.10.1007/s00439-008-0529-1

18 August 2017

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cites work

Concerted transcriptional regulation by BRCA1 and COBRA1 in breast cancer cells

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https://api.crossref.org/works/10.1007%2FS00439-008-0529-1

A novel cell cycle inhibitor stalls replication forks and activates S phase checkpoint.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00439-008-0529-1

Shared genetic susceptibility to breast cancer, brain tumors, and Fanconi anemia

21 January 2018

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Telomeres, stem cells, senescence, and cancer

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E-cadherin gene mutations provide clues to diffuse type gastric carcinomas

21 January 2018

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12 December 2020

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

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12 December 2020

Network modeling links breast cancer susceptibility and centrosome dysfunction

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12 December 2020

Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33.

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12 December 2020

ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks

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12 December 2020

Rapamycin inhibits multiple stages of c-Neu/ErbB2 induced tumor progression in a transgenic mouse model of HER2-positive breast cancer

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12 December 2020

Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells

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12 December 2020

BRCA1 functions as a breast stem cell regulator

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12 December 2020

SUMO1 negatively regulates BRCA1-mediated transcription, via modulation of promoter occupancy

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12 December 2020

PTEN function in normal and neoplastic growth

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12 December 2020

Breast carcinoma with basal differentiation: a proposal for pathology definition based on basal cytokeratin expression.

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12 December 2020

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

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12 December 2020

Increased risk of breast cancer associated with CHEK2*1100delC

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12 December 2020

TGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study

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12 December 2020

The LKB1 tumor suppressor kinase in human disease

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12 December 2020

Determination of the frequency of the common 657Del5 Nijmegen breakage syndrome mutation in the German population: no association with risk of breast cancer

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12 December 2020

Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response

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12 December 2020

Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers

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12 December 2020

Common variants on chromosome 5p12 confer susceptibility to estrogen receptor–positive breast cancer

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12 December 2020

Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated

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12 December 2020

Genome-wide association study identifies novel breast cancer susceptibility loci

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12 December 2020

The ubiquitin E3 ligase activity of BRCA1 and its biological functions.

1 reference

12 December 2020

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

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12 December 2020

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

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12 December 2020

The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

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12 December 2020

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

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12 December 2020

Deregulation of cofactor of BRCA1 expression in breast cancer cells

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12 December 2020

Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles

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12 December 2020

A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer

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12 December 2020

Hereditary breast cancer: part I. Diagnosing hereditary breast cancer syndromes

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12 December 2020

Molecular portraits of human breast tumours

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12 December 2020

Frequency and spectrum of cancers in the Peutz-Jeghers syndrome

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12 December 2020

Sox2: a possible driver of the basal-like phenotype in sporadic breast cancer

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12 December 2020

microRNAs join the p53 network--another piece in the tumour-suppression puzzle

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12 December 2020

Fanconi anemia and breast cancer susceptibility

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12 December 2020

The Cowden syndrome: a clinical and genetic study in 21 patients

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12 December 2020

Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers

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12 December 2020

Patterns of somatic mutation in human cancer genomes

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12 December 2020

RAD51 135G-->C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies

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12 December 2020

Nijmegen Breakage Syndrome mutations and risk of breast cancer

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12 December 2020

hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes

1 reference

12 December 2020

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

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12 December 2020

BRCA2: a universal recombinase regulator.

1 reference

12 December 2020

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

1 reference

12 December 2020

Repeated observation of breast tumor subtypes in independent gene expression data sets

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12 December 2020

Follow-up study of twenty-four families with Li-Fraumeni syndrome

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12 December 2020

Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells

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12 December 2020

A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study

1 reference

12 December 2020

ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models

1 reference

12 December 2020

Clinical practice. Management of an inherited predisposition to breast cancer

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12 December 2020

Inherited p53 gene mutations in breast cancer

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12 December 2020

The genomic landscapes of human breast and colorectal cancers

1 reference

12 December 2020

BRCA2: a cause of Li-Fraumeni-like syndrome

1 reference

12 December 2020

Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations

1 reference

12 December 2020

The consensus coding sequences of human breast and colorectal cancers

1 reference

12 December 2020

Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer

1 reference

12 December 2020

Dynamic interactions between the promoter and terminator regions of the mammalian BRCA1 gene

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12 December 2020

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

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12 December 2020

Human CtIP promotes DNA end resection

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12 December 2020

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

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12 December 2020

Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1

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12 December 2020

Screening for germ line TP53 mutations in breast cancer patients

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12 December 2020

Troglitazone inhibits cell migration, adhesion, and spreading by modulating cytoskeletal rearrangement in human breast cancer cells

1 reference

12 December 2020

Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population.

1 reference

12 December 2020

BRCA2 mutation-associated breast cancers exhibit a distinguishing phenotype based on morphology and molecular profiles from tissue microarrays

1 reference

12 December 2020

A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer

1 reference

12 December 2020

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

1 reference

12 December 2020

PTEN regulates phospholipase D and phospholipase C.

1 reference

12 December 2020

Germline mutations 657del5 of the NBS1 gene contribute significantly to the incidence of breast cancer in Central Poland

1 reference

12 December 2020

Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer.

1 reference

12 December 2020

Identification of the breast cancer susceptibility gene BRCA2

1 reference

12 December 2020

Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins

1 reference

12 December 2020

Targeting the checkpoint kinases: chemosensitization versus chemoprotection

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12 December 2020

BRCA1 and BRCA2: chemosensitivity, treatment outcomes and prognosis

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12 December 2020

Heterozygous ATM mutations do not contribute to early onset of breast cancer

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12 December 2020

The incidence and gene frequency of ataxia-telangiectasia in the United States

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12 December 2020

Biallelic inactivation of BRCA2 in Fanconi anemia

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12 December 2020

Evaluation ofRAD50 in familial breast cancer predisposition

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12 December 2020

Essential role for nuclear PTEN in maintaining chromosomal integrity

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12 December 2020

PTEN: tumour suppressor, multifunctional growth regulator and more

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12 December 2020

Indole-3-carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells

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12 December 2020

BRCA1 regulates human mammary stem/progenitor cell fate

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12 December 2020

Cancer risks and mortality in heterozygous ATM mutation carriers

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12 December 2020

Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair.

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12 December 2020

Role played by BRCA1 in transcriptional regulation in response to therapy

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12 December 2020

Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response

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12 December 2020

Ubiquitination regulates PTEN nuclear import and tumor suppression

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12 December 2020

Prediction of BRCA1 status in patients with breast cancer using estrogen receptor and basal phenotype

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12 December 2020

RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability

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12 December 2020

TOR signaling in growth and metabolism

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12 December 2020

S-Allylcysteine reduces breast tumor cell adhesion and invasion

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12 December 2020

Deficient TP53 expression, function, and cisplatin sensitivity are restored by quinacrine in head and neck cancer

1 reference

12 December 2020

Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation

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12 December 2020

Multifactorial analysis of differences between sporadic breast cancers and cancers involving BRCA1 and BRCA2 mutations.

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12 December 2020

Fibroblast growth factor signaling in tumorigenesis

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12 December 2020

A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

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12 December 2020

Germline E-cadherin mutations in familial lobular breast cancer

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12 December 2020

Current development of clinical inhibitors of poly(ADP-ribose) polymerase in oncology

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12 December 2020

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

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12 December 2020

hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

1 reference

12 December 2020

Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo

1 reference

12 December 2020

Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer

1 reference

12 December 2020

Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases

1 reference

12 December 2020

BRCA1 and BRCA2: 1994 and beyond

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12 December 2020

Variation of breast cancer risk among BRCA1/2 carriers

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12 December 2020

The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly

1 reference

12 December 2020

Novel therapeutic strategies combining antihormonal and biological targeted therapies in breast cancer: focus on clinical trials and perspectives.

1 reference

12 December 2020

BRCA1—sowing the seeds crooked in the furrow

1 reference

12 December 2020

Relative frequency and morphology of cancers in STK11 mutation carriers

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12 December 2020

Living with p53, dying of p53.

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12 December 2020

Genetic heterogeneity among Fanconi anemia heterozygotes and risk of cancer

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12 December 2020

Germline CHEK2 mutations in Jewish Ashkenazi women at high risk for breast cancer

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12 December 2020

Evaluation of Fanconi Anemia genes in familial breast cancer predisposition

1 reference

12 December 2020

A common coding variant in CASP8 is associated with breast cancer risk

1 reference

12 December 2020

Molecular basis for estrogen receptor alpha deficiency in BRCA1-linked breast cancer.

1 reference

12 December 2020

Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors

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12 December 2020

NBS1 657del5 mutation may contribute only to a limited fraction of breast cancer cases in Russia.

1 reference

12 December 2020

Incidence of gastric cancer and breast cancer in CDH1 (E-cadherin) mutation carriers from hereditary diffuse gastric cancer families

1 reference

12 December 2020

Cowden disease. Report of a family and review

1 reference

12 December 2020

Linkage of early-onset familial breast cancer to chromosome 17q21

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12 December 2020

Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis

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12 December 2020

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

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12 December 2020

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

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12 December 2020

Localization of breast cancer susceptibility loci by genome-wide SNP linkage disequilibrium mapping

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12 December 2020

CR229, a novel derivative of beta-carbolin-1-one, induces cell cycle arrest and apoptosis in HeLa cells via p53 activation

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12 December 2020

Very high risk of cancer in familial Peutz-Jeghers syndrome

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12 December 2020

ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles

1 reference

12 December 2020

The Fanconi anaemia/BRCA pathway and cancer susceptibility. Searching for new therapeutic targets.

1 reference

12 December 2020

Influence of BRCA1 mutations on nuclear grade and estrogen receptor status of breast carcinoma in Ashkenazi Jewish women

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12 December 2020

Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair.

1 reference

12 December 2020

CHEK2*1100delC and susceptibility to breast cancer: a collaborative analysis involving 10,860 breast cancer cases and 9,065 controls from 10 studies

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12 December 2020

Growth rate and cell size modulate the synthesis of, and requirement for, G1-phase cyclins at start

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12 December 2020

E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells

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12 December 2020

Cancer risks in LKB1 germline mutation carriers.

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12 December 2020

Higher occurrence of childhood cancer in families with germline mutations in BRCA2, MMR and CDKN2A genes

1 reference

12 December 2020

Involvement of PPAR gamma and E-cadherin/beta-catenin pathway in the antiproliferative effect of conjugated linoleic acid in MCF-7 cells

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12 December 2020

Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies

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12 December 2020

10.1007/S00439-008-0529-1

Identifiers

DOI

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18 August 2017

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PubMed ID

18575892