PTEN: tumour suppressor, multifunctional growth regulator and more (Q35203208)

7 August 2017

1 reference

title

PTEN: tumour suppressor, multifunctional growth regulator and more (English)

1 reference

7 August 2017

Deborah C I Goberdhan

series ordinal

1

1 reference

PubMed ID

12928488

7 August 2017

Clive Wilson

series ordinal

2

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7 August 2017

19 August 2003

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7 August 2017

Human Molecular Genetics

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7 August 2017

12 Spec No 2

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7 August 2017

R239-48

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

7 August 2017

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

PTEN and myotubularin: novel phosphoinositide phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Germline and germline mosaic PTEN mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arteriovenous malformations and lipomatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

PTEN mutations are uncommon in Proteus syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

PTEN function in mammalian cell size regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Physiological functions of Pten in mouse tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Shc and FAK differentially regulate cell motility and directionality modulated by PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

PTEN: The down side of PI 3-kinase signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Rheb promotes cell growth as a component of the insulin/TOR signalling network

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Akt regulates growth by directly phosphorylating Tsc2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Genetic control of cell size

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Insulin receptor-mediated organ overgrowth in Drosophila is not restricted by body size

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Pten is essential for embryonic development and tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

PTEN in neural precursor cells: regulation of migration, apoptosis, and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

The conserved phosphoinositide 3-kinase pathway determines heart size in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Signaling pathways of D3-phosphoinositide-binding kinases in T cells and their regulation by PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Regulation of Drosophila tracheal system development by protein kinase B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Tumor suppressor PTEN mediates sensing of chemoattractant gradients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Polarization of chemoattractant receptor signaling during neutrophil chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Neutrophils lacking phosphoinositide 3-kinase gamma show loss of directionality during N-formyl-Met-Leu-Phe-induced chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Invasive cell migration is initiated by guided growth of long cellular extensions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Phosphorylation of the PTEN tail regulates protein stability and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Membrane-binding and activation mechanism of PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Direct identification of PTEN phosphorylation sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Negative feedback regulation of the tumor suppressor PTEN by phosphoinositide-induced serine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

21 January 2018

p53: good cop/bad cop.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

A role for p53 in base excision repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Regulation of PTEN transcription by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Inhibition of vascular smooth muscle cell proliferation, migration, and survival by the tumor suppressor protein PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Association of germline mutation in the PTEN tumour suppressor gene and Proteus and Proteus-like syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDG288

21 January 2018

Identifiers

DOI

10.1093/HMG/DDG288

1 reference

7 August 2017

1 reference

PubMed ID

12928488