Exploring the reactivity of flavonoid compounds with metal-associated amyloid-β species (Q37222626)

19 August 2017

Exploring the reactivity of flavonoid compounds with metal-associated amyloid-β species (English)

1 reference

19 August 2017

Suk-Joon Hyung

3

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Brandon T. Ruotolo

object named as

Brandon T Ruotolo

6

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author name string

Xiaoming He

1

1 reference

19 August 2017

Hyun Min Park

2

1 reference

19 August 2017

Alaina S DeToma

4

1 reference

19 August 2017

Cheal Kim

5

1 reference

19 August 2017

Mi Hee Lim

7

1 reference

19 August 2017

language of work or name

English

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publication date

22 March 2012

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19 August 2017

1 reference

19 August 2017

41

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19 August 2017

21

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19 August 2017

6558-6566

1 reference

Metal-associated amyloid-β species in Alzheimer's disease

19 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007133

Development of bifunctional stilbene derivatives for targeting and modulating metal-amyloid-β species.

6 September 2017

1 reference

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Misfolded proteins in Alzheimer's disease and type II diabetes.

6 September 2017

1 reference

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The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity

6 September 2017

1 reference

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Myricetin: a naturally occurring regulator of metal-induced amyloid-β aggregation and neurotoxicity

6 September 2017

1 reference

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Interactions of Zn(II) and Cu(II) ions with Alzheimer's amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicity

6 September 2017

1 reference

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Role of metal dyshomeostasis in Alzheimer's disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007133

Recent Development of Bifunctional Small Molecules to Study Metal-Amyloid-β Species in Alzheimer's Disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007133

Design of small molecules that target metal-A{beta} species and regulate metal-induced A{beta} aggregation and neurotoxicity.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007133

Cu K-edge X-ray absorption spectroscopy reveals differential copper coordination within amyloid-β oligomers compared to amyloid-β monomers

6 September 2017

1 reference

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Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease

6 September 2017

1 reference

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Naturally occurring phytochemicals for the prevention of Alzheimer's disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007133

Copper and zinc binding to amyloid-beta: coordination, dynamics, aggregation, reactivity and metal-ion transfer

6 September 2017

1 reference

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The chemistry of Alzheimer's disease

6 September 2017

1 reference

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Medicinal inorganic chemistry approaches to passivation and removal of aberrant metal ions in disease

6 September 2017

1 reference

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Abeta-mediated ROS production by Cu ions: structural insights, mechanisms and relevance to Alzheimer's disease.

6 September 2017

1 reference

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Alzheimer's disease: from pathology to therapeutic approaches

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007133

Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-beta peptide

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007133

Therapeutics for Alzheimer's disease based on the metal hypothesis

6 September 2017

1 reference

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Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007133

Copper homeostasis and neurodegenerative disorders (Alzheimer's, prion, and Parkinson's diseases and amyotrophic lateral sclerosis).

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007133

Inhibition of amyloid fibril formation by polyphenols: structural similarity and aromatic interactions as a common inhibition mechanism

6 September 2017

1 reference

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The neurobiology of zinc in health and disease

6 September 2017

1 reference

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007133

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007133

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007133

Computational methods for the prediction of 'drug-likeness'

6 September 2017

1 reference

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Antioxidant activity applying an improved ABTS radical cation decolorization assay

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007133

Solution structure of amyloid beta-peptide(1-40) in a water-micelle environment. Is the membrane-spanning domain where we think it is?

6 September 2017

1 reference

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The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase

6 September 2017

1 reference

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Small molecule modulators of copper-induced Abeta aggregation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007133

Dual excited-state intramolecular proton transfer reaction in 3-hydroxy-2-(pyridin-2-yl)-4H-chromen-4-one

14 September 2017

1 reference

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Sequestration of copper from beta-amyloid promotes selective lysis by cyclen-hybrid cleavage agents

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007133

Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007133

Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007133

Structure-antioxidant activity relationships of flavonoids and phenolic acids

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007133

Structural studies of copper(I) complexes of amyloid-beta peptide fragments: formation of two-coordinate bis(histidine) complexes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007133

Copper, iron and zinc in Alzheimer's disease senile plaques

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007133

Synthesis and characterization of IMPY derivatives that regulate metal-induced amyloid-β aggregation.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007133

An effective synthesis of 5,4'-disubstituted flavones via a cesium enolate assisted intramolecular ipso-substitution reaction.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007133

PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses

3 September 2018

1 reference

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Effect of Zinc (II) on the interactions of bovine serum albumin with flavonols bearing different number of hydroxyl substituent on B-ring

3 September 2018

1 reference

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18F-labeled flavones for in vivo imaging of beta-amyloid plaques in Alzheimer's brains

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007133

Design, selection, and characterization of thioflavin-based intercalation compounds with metal chelating properties for application in Alzheimer's disease

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007133

Thioflavin derivatives as markers for amyloid-beta fibrils: insights into structural features important for high-affinity binding.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007133

Positioning of the Alzheimer Abeta(1-40) peptide in SDS micelles using NMR and paramagnetic probes.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007133

Combating Alzheimer's disease with multifunctional molecules designed for metal passivation.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007133

Influence of chelators and iron ions on the production and degradation of H2O2 by beta-amyloid-copper complexes.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007133

Radioiodinated flavones for in vivo imaging of beta-amyloid plaques in the brain

3 September 2018

1 reference

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Interactions of flavonoids with iron and copper ions: a mechanism for their antioxidant activity.

3 September 2018

1 reference

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Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

3 September 2018

1 reference

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Identification by NMR of the binding surface for the histidine-containing phosphocarrier protein HPr on the N-terminal domain of enzyme I of the Escherichia coli phosphotransferase system.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007133

Hyperquad simulation and speciation (HySS): a utility program for the investigation of equilibria involving soluble and partially soluble species

3 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1039%2FC2DT12207C

Dietary flavonoids: intake, health effects and bioavailability

21 January 2018

1 reference

12 December 2020

The chelation targeting metal-Aβ40 aggregates may lead to formation of Aβ40 oligomers

1 reference

12 December 2020

The anti-amyloidogenic effect is exerted against Alzheimer's beta-amyloid fibrils in vitro by preferential and reversible binding of flavonoids to the amyloid fibril structure

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12 December 2020

Chemical shift as a probe of molecular interfaces: NMR studies of DNA binding by the three amino-terminal zinc finger domains from transcription factor IIIA

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12 December 2020

Identifiers

DOI

10.1039/C2DT12207C

1 reference

19 August 2017

1 reference

19 August 2017

PubMed publication ID

22437427

1 reference