Relaxin and its role in the development and treatment of fibrosis (Q37229308)

19 August 2017

1 reference

title

Relaxin and its role in the development and treatment of fibrosis (English)

1 reference

19 August 2017

Robert G Bennett

1

1 reference

19 August 2017

22 April 2009

1 reference

19 August 2017

Translational Research

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19 August 2017

154

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19 August 2017

1

1 reference

19 August 2017

1-6

1 reference

Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2

19 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Relaxin-3 stimulates the hypothalamic-pituitary-gonadal axis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

The myofibroblast: one function, multiple origins

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Relaxin as a cardiovascular hormone: physiology, pathophysiology and therapeutic promises

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Relaxin in cardiovascular and renal disease.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Relaxin-a pleiotropic hormone and its emerging role for experimental and clinical therapeutics.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Endogenous relaxin regulates collagen deposition in an animal model of allergic airway disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Genetic targeting of relaxin and insulin-like factor 3 receptors in mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Relaxin's physiological roles and other diverse actions

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Activation of orphan receptors by the hormone relaxin

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Relaxin decreases renal interstitial fibrosis and slows progression of renal disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Targeted disruption of the Insl3 gene causes bilateral cryptorchidism

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Cloning of a cDNA for a novel insulin-like peptide of the testicular Leydig cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathway

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Relaxin reduces fibrosis in models of progressive and established hepatic fibrosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Effect of relaxin in two models of renal mass reduction

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Utilization of the releaxed symphysis pubis of guinea pigs for clues to the mechanism of ovulation

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Relaxin modulates synthesis and secretion of procollagenase and collagen by human dermal fibroblasts

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Relaxin family peptide receptor-1 protects against airway fibrosis during homeostasis but not against fibrosis associated with chronic allergic airways disease.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Endogenous relaxin does not affect chronic pressure overload-induced cardiac hypertrophy and fibrosis

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Adenovirus-mediated delivery of relaxin reverses cardiac fibrosis

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

The effects of relaxin and estrogen deficiency on collagen deposition and hypertrophy of nonreproductive organs.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Endocrine effects of relaxin overexpression in mice

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Effect of relaxin on myocardial ischemia injury induced by isoproterenol

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Relaxin reverses cardiac and renal fibrosis in spontaneously hypertensive rats

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Relaxin-1-deficient mice develop an age-related progression of renal fibrosis

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Inhibition of markers of hepatic stellate cell activation by the hormone relaxin

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Relaxin increases ubiquitin-dependent degradation of fibronectin in vitro and ameliorates renal fibrosis in vivo

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Increased myocardial collagen and ventricular diastolic dysfunction in relaxin deficient mice: a gender-specific phenotype.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

The vasorelaxant hormone relaxin induces changes in liver sinusoid microcirculation: a morphologic study in the rat.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

Human relaxin decreases collagen accumulation in vivo in two rodent models of fibrosis

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2697124

A novel Leydig cell cDNA-derived protein is a relaxin-like factor

3 September 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2009.03.007

Effects of acute and chronic relaxin-3 on food intake and energy expenditure in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2009.03.007

Collagen studies in late pregnant relaxin null mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2009.03.007

The relaxin gene-knockout mouse: a model of progressive fibrosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2009.03.007

Relaxin alone and in conjunction with interferon-gamma decreases collagen synthesis by cultured human scleroderma fibroblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2009.03.007

The relaxin gene knockout mouse: a model of progressive scleroderma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2009.03.007

Use of relaxin in the treatment of scleroderma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2009.03.007

Recombinant human relaxin in the treatment of scleroderma. A randomized, double-blind, placebo-controlled trial

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2009.03.007

Relaxins: lessons and limitations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2009.03.007

Relaxin deficiency in mice is associated with an age-related progression of pulmonary fibrosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2009.03.007

Relaxin plays an important role in the regulation of airway structure and function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2009.03.007

Relaxin down-regulates renal fibroblast function and promotes matrix remodelling in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2009.03.007

Relaxin improves renal function and histology in aging Munich Wistar rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2009.03.007

Endogenous relaxin is a naturally occurring modulator of experimental renal tubulointerstitial fibrosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2009.03.007

Relaxin ameliorates fibrosis in experimental diabetic cardiomyopathy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2009.03.007

Relaxin receptors in hepatic stellate cells and cirrhotic liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2009.03.007

10.1016/J.TRSL.2009.03.007

7 January 2021

Identifiers

DOI

1 reference

19 August 2017

1 reference

19 August 2017

1 reference

PMCID

2697124