Hsc70 negatively regulates epithelial sodium channel trafficking at multiple sites in epithelial cells (Q37234555)

19 August 2017

Hsc70 negatively regulates epithelial sodium channel trafficking at multiple sites in epithelial cells (English)

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19 August 2017

Rebecca A Chanoux

1

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19 August 2017

Calla B Shubin

2

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19 August 2017

Amal Robay

3

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19 August 2017

Laurence Suaud

4

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19 August 2017

Ronald C Rubenstein

5

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19 August 2017

24 July 2013

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American Journal of Physiology - Cell Physiology

19 August 2017

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19 August 2017

305

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19 August 2017

7

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19 August 2017

C776-87

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describes a project that uses

19 August 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3798670/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Hsp70 promotes epithelial sodium channel functional expression by increasing its association with coat complex II and its exit from endoplasmic reticulum.

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4-Phenylbutyrate stimulates Hsp70 expression through the Elp2 component of elongator and STAT-3 in cystic fibrosis epithelial cells

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6 September 2017

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cAMP increases density of ENaC subunits in the apical membrane of MDCK cells in direct proportion to amiloride-sensitive Na(+) transport

6 September 2017

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6 September 2017

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Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel

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Liddle's syndrome: a novel mouse Nedd4 isoform regulates the activity of the epithelial Na(+) channel

6 September 2017

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Hsp70 molecular chaperone facilitates endoplasmic reticulum-associated protein degradation of cystic fibrosis transmembrane conductance regulator in yeast

6 September 2017

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Dominant-interfering Hsc70 mutants disrupt multiple stages of the clathrin-coated vesicle cycle in vivo

6 September 2017

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A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel

6 September 2017

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The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

6 September 2017

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Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease

6 September 2017

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Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination

6 September 2017

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A mutation causing pseudohypoaldosteronism type 1 identifies a conserved glycine that is involved in the gating of the epithelial sodium channel

6 September 2017

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WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome

6 September 2017

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Inhibition of immunoglobulin folding and secretion by dominant negative BiP ATPase mutants

6 September 2017

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Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1

6 September 2017

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Molecular properties of epithelial, amiloride-blockable Na+ channels

6 September 2017

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Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits

6 September 2017

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Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel

6 September 2017

1 reference

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Membrane topology of the epithelial sodium channel in intact cells

6 September 2017

1 reference

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In vivo expression of mammalian BiP ATPase mutants causes disruption of the endoplasmic reticulum

6 September 2017

1 reference

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A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins

6 September 2017

1 reference

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Uncoating protein (hsc70) binds a conformationally labile domain of clathrin light chain LCa to stimulate ATP hydrolysis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798670

Epithelial sodium channel exit from the endoplasmic reticulum is regulated by a signal within the carboxyl cytoplasmic domain of the alpha subunit

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798670

The PY motif of ENaC, mutated in Liddle syndrome, regulates channel internalization, sorting and mobilization from subapical pool

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798670

Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma-subunit.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798670

Neutrophil elastase activates near-silent epithelial Na+ channels and increases airway epithelial Na+ transport.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798670

Distinct pools of epithelial sodium channels are expressed at the plasma membrane

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798670

Epithelial sodium channels are activated by furin-dependent proteolysis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798670

Relative contribution of Nedd4 and Nedd4-2 to ENaC regulation in epithelia determined by RNA interference

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798670

Gene expression profile analysis of 4-phenylbutyrate treatment of IB3-1 bronchial epithelial cell line demonstrates a major influence on heat-shock proteins

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798670

Induction of HSP70 promotes DeltaF508 CFTR trafficking

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798670

Sodium 4-phenylbutyrate downregulates HSC70 expression by facilitating mRNA degradation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798670

Electrophysiological characterization of the rat epithelial Na+ channel (rENaC) expressed in MDCK cells. Effects of Na+ and Ca2+.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798670

Epithelial sodium channel (ENaC) is multi-ubiquitinated at the cell surface

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798670

Serine protease activation of near-silent epithelial Na+ channels

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798670

Liddle's syndrome caused by a novel missense mutation (P617L) of the epithelial sodium channel beta subunit

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798670

Altered ENaC expression leads to impaired sodium absorption in the noninflamed intestine in Crohn's disease.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798670

The deubiquitinating enzyme UCH-L3 regulates the apical membrane recycling of the epithelial sodium channel

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798670

Modulation of epithelial sodium channel trafficking and function by sodium 4-phenylbutyrate in human nasal epithelial cells

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798670

Dysfunction of the epithelial sodium channel expressed in the kidney of a mouse model for Liddle syndrome

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798670

Maturation of the epithelial Na+ channel involves proteolytic processing of the alpha- and gamma-subunits

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798670

The serine protease trypsin cleaves C termini of beta- and gamma-subunits of epithelial Na+ channels

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798670

Uncoating of clathrin-coated vesicles in presynaptic terminals: roles for Hsc70 and auxilin

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798670

Biosynthesis and processing of epithelial sodium channels in Xenopus oocytes

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3798670

Ubiquitin-dependent degradation of certain protein substrates in vitro requires the molecular chaperone Hsc70

3 September 2018

1 reference

12 December 2020

Sodium 4-phenylbutyrate upregulates ENaC and sodium absorption in T84 cells

1 reference

12 December 2020

Absence of amiloride-sensitive sodium absorption in the airway of an infant with pseudohypoaldosteronism

1 reference

12 December 2020

Sodium 4-phenylbutyrate downregulates Hsc70: implications for intracellular trafficking of DeltaF508-CFTR

1 reference

12 December 2020

10.1152/AJPCELL.00059.2013

Identifiers

DOI

1 reference

19 August 2017

1 reference

19 August 2017

PubMed publication ID

23885065

1 reference