New insulin analogues and routes of delivery: pharmacodynamic and clinical considerations (Q37242616)

19 August 2017

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title

New insulin analogues and routes of delivery: pharmacodynamic and clinical considerations (English)

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19 August 2017

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Paris Roach

1

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PubMed ID

18698880

19 August 2017

language of work or name

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1 January 2008

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Clinical Pharmacokinetics

19 August 2017

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19 August 2017

47

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19 August 2017

595-610

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19 August 2017

9

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https://scigraph.springernature.com/pub.10.2165/00003088-200847090-00003

19 August 2017

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Improved postprandial metabolic control after subcutaneous injection of a short-acting insulin analog in IDDM of short duration with residual pancreatic beta-cell function.

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Insulin aspart (B28 asp-insulin): a fast-acting analog of human insulin: absorption kinetics and action profile compared with regular human insulin in healthy nondiabetic subjects

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Comparison of Pharmacokinetics and Dynamics of the Long-Acting Insulin Analogs Glargine and Detemir at Steady State in Type 1 Diabetes: A double-blind, randomized, crossover study

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Time-action profile of the long-acting insulin analog insulin glargine (HOE901) in comparison with those of NPH insulin and placebo

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Lower within-subject variability of insulin detemir in comparison to NPH insulin and insulin glargine in people with type 1 diabetes

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Future directions for insulin therapy and diabetes treatment

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Engineering predictability and protraction in a basal insulin analogue: the pharmacology of insulin detemir

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Injection-meal interval: recommendations of diabetologists and how patients handle it.

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Postprandial insulin lispro. A new therapeutic option for type 1 diabetic patients

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Factors influencing the absorption, serum insulin concentration, and blood glucose responses after injections of regular insulin and various insulin mixtures.

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Efficacy and safety of inhaled insulin (exubera) compared with subcutaneous insulin therapy in patients with type 2 diabetes: results of a 6-month, randomized, comparative trial

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Pharmacokinetic and glucodynamic variability: assessment of insulin glargine, NPH insulin and insulin ultralente in healthy volunteers using a euglycaemic clamp technique

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Efficacy and safety of insulin glulisine in patients with type 1 diabetes

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Optimal time of administration of insulin lispro. Importance of meal composition

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Dose-response relationship of an oral insulin spray in six patients with type 1 diabetes: a single-center, randomized, single-blind, 5-way crossover study

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Albumin-bound basal insulin analogues (insulin detemir and NN344): comparable time-action profiles but less variability than insulin glargine in type 2 diabetes

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Novel methods of insulin delivery: an update

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Comparison of three multiple injection regimens for Type 1 diabetes: morning plus dinner or bedtime administration of insulin detemir vs. morning plus bedtime NPH insulin

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Inhaled insulin using the AERx Insulin Diabetes Management System in healthy and asthmatic subjects

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No evidence for accumulation of insulin glargine (LANTUS): a multiple injection study in patients with Type 1 diabetes

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Insulin glulisine provides improved glycemic control in patients with type 2 diabetes

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Towards peakless, reproducible and long-acting insulins. An assessment of the basal analogues based on isoglycaemic clamp studies

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12 December 2020

Effect of insulin concentration, subcutaneous fat thickness and skin temperature on subcutaneous insulin absorption in healthy subjects

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A randomized clinical trial comparing breakfast, dinner, or bedtime administration of insulin glargine in patients with type 1 diabetes

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12 December 2020

To: Scholtz HE, Pretorius SG, Wessels DH, Becker RHA (2005) Pharmacokinetic and glucodynamic variability: assessment of insulin glargine, NPH insulin and insulin ultralente in healthy volunteers using a euglycaemic clamp technique. Diabetologia 48:1

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12 December 2020

Pharmacokinetics and pharmacodynamics of the long-acting insulin analog glargine after 1 week of use compared with its first administration in subjects with type 1 diabetes

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12 December 2020

Dose-response relation of liquid aerosol inhaled insulin in type I diabetic patients

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12 December 2020

Time-action profile of the soluble, fatty acid acylated, long-acting insulin analogue NN304

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12 December 2020

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12 December 2020

Safety and efficacy of insulin detemir in clinical practice: 14-week follow-up data from type 1 and type 2 diabetes patients in the PREDICTIVE European cohort

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12 December 2020

Direct comparison of insulin lispro and aspart shows small differences in plasma insulin profiles after subcutaneous injection in type 1 diabetes

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12 December 2020

Large porous particles for pulmonary drug delivery

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12 December 2020

Parenteral absorption of insulin from the lung in diabetic children

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12 December 2020

Insulin detemir is associated with more predictable glycemic control and reduced risk of hypoglycemia than NPH insulin in patients with type 1 diabetes on a basal-bolus regimen with premeal insulin aspart

1 reference

12 December 2020

Oral modified insulin (HIM2) in patients with type 1 diabetes mellitus: results from a phase I/II clinical trial

1 reference

12 December 2020

Effects of the short-acting insulin analog [Lys(B28),Pro(B29)] on postprandial blood glucose control in IDDM

1 reference

12 December 2020

Insulin analogues (insulin detemir and insulin aspart) versus traditional human insulins (NPH insulin and regular human insulin) in basal-bolus therapy for patients with type 1 diabetes.

1 reference

12 December 2020

Efficacy of conversion from bedtime NPH insulin injection to once- or twice-daily injections of insulin glargine in type 1 diabetic patients using basal/bolus therapy

1 reference

12 December 2020

Time-action profile of inhaled insulin in comparison with subcutaneously injected insulin lispro and regular human insulin

1 reference

12 December 2020

Comparison of insulin detemir and insulin glargine in subjects with Type 1 diabetes using intensive insulin therapy

1 reference

12 December 2020

Long-term efficacy and safety of insulin detemir compared to Neutral Protamine Hagedorn insulin in patients with Type 1 diabetes using a treat-to-target basal-bolus regimen with insulin aspart at meals: a 2-year, randomized, controlled trial

1 reference

12 December 2020

Absorption of radiolabelled soluble insulin in type 1 (insulin-dependent) diabetes: influence of subcutaneous blood flow and anthropometry

1 reference

12 December 2020

Technosphere/Insulin--proof of concept study with a new insulin formulation for pulmonary delivery

1 reference

12 December 2020

Use of inhaled insulin in a basal/bolus insulin regimen in type 1 diabetic subjects: a 6-month, randomized, comparative trial

1 reference

12 December 2020

Comparison of the pharmacokinetics and pharmacodynamics of biphasic insulin aspart and insulin glargine in people with type 2 diabetes

1 reference

12 December 2020

Meal composition is a determinant of lispro-induced hypoglycemia in IDDM

1 reference

12 December 2020

Insulin glulisine, a new rapid-acting insulin analogue, displays a rapid time-action profile in obese non-diabetic subjects

1 reference

12 December 2020

Novel forms of insulin delivery

1 reference

12 December 2020

Dose response of inhaled dry-powder insulin and dose equivalence to subcutaneous insulin lispro

1 reference

12 December 2020

Insulin detemir offers improved glycemic control compared with NPH insulin in people with type 1 diabetes: a randomized clinical trial

1 reference

12 December 2020

10.2165/00003088-200847090-00003

Identifiers

DOI

1 reference

PubMed ID

18698880

Dimensions Publication ID

19 August 2017

0 references

1 reference

PubMed ID

18698880