Breast cancer epigenetics: normal human mammary epithelial cells as a model system (Q37248365)

19 August 2017

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title

Breast cancer epigenetics: normal human mammary epithelial cells as a model system (English)

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19 August 2017

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Rebecca A Hinshelwood

series ordinal

1

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PubMed ID

18716754

19 August 2017

Susan J Clark

series ordinal

2

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19 August 2017

21 August 2008

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Journal of Molecular Medicine

19 August 2017

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19 August 2017

86

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19 August 2017

12

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19 August 2017

1315-1328

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https://scigraph.springernature.com/pub.10.1007/s00109-008-0386-3

19 August 2017

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cites work

Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications.

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00109-008-0386-3

The history of cancer epigenetics

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00109-008-0386-3

Inactivation of p16 in human mammary epithelial cells by CpG island methylation

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00109-008-0386-3

The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation

21 January 2018

1 reference

12 December 2020

DNA methylation and specific protein-DNA interactions

1 reference

12 December 2020

Somatic mutations in the BRCA1 gene in sporadic ovarian tumours.

1 reference

12 December 2020

Methylation-associated silencing of heparan sulfate D-glucosaminyl 3-O-sulfotransferase-2 (3-OST-2) in human breast, colon, lung and pancreatic cancers

1 reference

12 December 2020

Tumour specific promoter region methylation of the human homologue of the Drosophila Roundabout gene DUTT1 (ROBO1) in human cancers

1 reference

12 December 2020

The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor cell colony formation.

1 reference

12 December 2020

Epigenetic silencing of the sulfotransferase 1A1 gene by hypermethylation in breast tissue

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12 December 2020

SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers

1 reference

12 December 2020

High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer

1 reference

12 December 2020

Epigenetic silencing of the tumor suppressor cystatin M occurs during breast cancer progression.

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12 December 2020

Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer

1 reference

12 December 2020

Aberrant promoter methylation of insulin-like growth factor binding protein-3 gene in human cancers.

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12 December 2020

Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia.

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12 December 2020

Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program

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12 December 2020

Cellular differentiation, cytidine analogs and DNA methylation

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12 December 2020

Association of breast cancer DNA methylation profiles with hormone receptor status and response to tamoxifen.

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12 December 2020

Hypermethylation trigger of the glutathione-S-transferase gene (GSTP1) in prostate cancer cells.

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12 December 2020

Glypican-3 expression is silenced in human breast cancer

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12 December 2020

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

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12 December 2020

Serum-free growth of human mammary epithelial cells: rapid clonal growth in defined medium and extended serial passage with pituitary extract

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12 December 2020

Polycomb silencers control cell fate, development and cancer

1 reference

12 December 2020

Somatic mutations in the BRCA1 gene in Chinese sporadic breast and ovarian cancer

1 reference

12 December 2020

TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers

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12 December 2020

Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.

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12 December 2020

Hypermethylation and silencing of the putative tumor suppressor Tazarotene-induced gene 1 in human cancers

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12 December 2020

Frequent epigenetic inactivation of cystatin M in breast carcinoma

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12 December 2020

Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancer

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12 December 2020

Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers.

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12 December 2020

Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus

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12 December 2020

Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

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12 December 2020

Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation.

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12 December 2020

Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors

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12 December 2020

Hypermethylation of the cpG island of Ras association domain family 1A (RASSF1A), a putative tumor suppressor gene from the 3p21.3 locus, occurs in a large percentage of human breast cancers

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12 December 2020

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers

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12 December 2020

Methylation of estrogen and progesterone receptor gene 5' CpG islands correlates with lack of estrogen and progesterone receptor gene expression in breast tumors

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12 December 2020

The Polycomb group protein EZH2 directly controls DNA methylation

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12 December 2020

Transcriptional gene silencing promotes DNA hypermethylation through a sequential change in chromatin modifications in cancer cells.

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12 December 2020

Altered methylation patterns in cancer cell genomes: cause or consequence?

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12 December 2020

New nomenclature for chromatin-modifying enzymes

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12 December 2020

The role of DNA methylation in cancer.

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12 December 2020

High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines.

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12 December 2020

DNA methylation-associated inactivation of TGFbeta-related genes DRM/Gremlin, RUNX3, and HPP1 in human cancers

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12 December 2020

De novo methylation of the MyoD1 CpG island during the establishment of immortal cell lines

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12 December 2020

Aberrant methylation of HIN-1 (high in normal-1) is a frequent event in many human malignancies

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12 December 2020

Hypermethylation leads to silencing of the SYK gene in human breast cancer.

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12 December 2020

Worms gang up on bacteria

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12 December 2020

Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation

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12 December 2020

DNA methylation and cancer

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12 December 2020

Mammalian DNA (cytosine-5) methyltransferases and their expression

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12 December 2020

Inactivation of human SRBC, located within the 11p15.5-p15.4 tumor suppressor region, in breast and lung cancers.

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12 December 2020

Identification of 20 genes aberrantly methylated in human breast cancers

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12 December 2020

Aberrant promoter methylation and silencing of laminin-5-encoding genes in breast carcinoma

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12 December 2020

Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone/protein methyltransferase superfamily

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12 December 2020

Causes of cancer in the world: comparative risk assessment of nine behavioural and environmental risk factors

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12 December 2020

Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA

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12 December 2020

The language of covalent histone modifications

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12 December 2020

Number of CpG islands and genes in human and mouse

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12 December 2020

Tumor suppressor gene promoter hypermethylation in serum of breast cancer patients.

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12 December 2020

Variable promoter region CpG island methylation of the putative tumor suppressor gene Connexin 26 in breast cancer

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12 December 2020

Silencing of the Tropomyosin-1 gene by DNA methylation alters tumor suppressor function of TGF-beta

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12 December 2020

Concordant epigenetic silencing of transforming growth factor-beta signaling pathway genes occurs early in breast carcinogenesis.

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12 December 2020

Aberrant CpG island methylation in cancer cell lines arises in the primary cancers from which they were derived.

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12 December 2020

DNA hypomethylation and human diseases.

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12 December 2020

Detection of breast cancer cells in ductal lavage fluid by methylation-specific PCR

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12 December 2020

Epigenetic suppression of secreted frizzled related protein 1 (SFRP1) expression in human breast cancer

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12 December 2020

Promoter methylation reduces C/EBPdelta (CEBPD) gene expression in the SUM-52PE human breast cancer cell line and in primary breast tumors

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12 December 2020

Cancer statistics, 2006

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12 December 2020

BRCA1 mutations in primary breast and ovarian carcinomas.

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12 December 2020

The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a

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12 December 2020

DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA

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12 December 2020

Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers

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12 December 2020

Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies

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12 December 2020

Trends in breast cancer by race and ethnicity

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12 December 2020

DNA methylation patterns and epigenetic memory

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12 December 2020

Epigenetic stem cell signature in cancer

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12 December 2020

DNA methylation analysis of the promoter region of the human telomerase reverse transcriptase (hTERT) gene.

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12 December 2020

Epigenetic silencing of DSC3 is a common event in human breast cancer

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12 December 2020

Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation

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12 December 2020

Methylation and silencing of the retinoic acid receptor-beta2 gene in breast cancer.

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12 December 2020

Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer

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12 December 2020

Aberrant methylation of p57KIP2 gene in lung and breast cancers and malignant mesotheliomas.

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12 December 2020

Discovery of aberrant expression of R-RAS by cancer-linked DNA hypomethylation in gastric cancer using microarrays

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12 December 2020

PTEN promoter is methylated in a proportion of invasive breast cancers

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12 December 2020

The cell cycle checkpoint gene Rad9 is a novel oncogene activated by 11q13 amplification and DNA methylation in breast cancer

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12 December 2020

Aberrant hypermethylation of ID4 gene promoter region increases risk of lymph node metastasis in T1 breast cancer.

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12 December 2020

Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways

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12 December 2020

Alternative chromatin structure at CpG islands

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12 December 2020

The DNA methylation paradox

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12 December 2020

Chromatin modifications and their function

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12 December 2020

DNA methylation and gene silencing in cancer: which is the guilty party?

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12 December 2020

Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer.

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12 December 2020

DNA methylation of RASSF1A, HIN‐1, RAR‐β, Cyclin D2 and Twist in in situ and invasive lobular breast carcinoma

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12 December 2020

Genetic and epigenetic changes in mammary epithelial cells may mimic early events in carcinogenesis

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12 December 2020

Compromised HOXA5 function can limit p53 expression in human breast tumours

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12 December 2020

Loss of p16INK4 expression by methylation is associated with lifespan extension of human mammary epithelial cells.

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12 December 2020

Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3.

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12 December 2020

Oncogene-induced basement membrane invasiveness in human mammary epithelial cells

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12 December 2020

DNA hypermethylation in tumorigenesis: epigenetics joins genetics

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12 December 2020

PubMeth: a cancer methylation database combining text-mining and expert annotation

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12 December 2020

Demethylation of urokinase promoter as a prognostic marker in patients with breast carcinoma.

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12 December 2020

Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours

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12 December 2020

Effects of transforming growth factor beta on growth of human mammary epithelial cells in culture

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12 December 2020

Mutation analysis of the BRCA1 gene in ovarian cancers.

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12 December 2020

Quantitative analysis of associations between DNA hypermethylation, hypomethylation, and DNMT RNA levels in ovarian tumors

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12 December 2020

Mutational, epigenetic and expressional analyses of caveolin-1 gene in breast cancers

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12 December 2020

Unanswered Questions about the Role of Promoter Methylation in Carcinogenesis

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12 December 2020

Chromatin Structure: A Repeating Unit of Histones and DNA

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12 December 2020

Epigenetic regulation of the expression of the novel stem cell marker CDCP1 in cancer cells

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12 December 2020

A human breast cell model of preinvasive to invasive transition.

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12 December 2020

CpG islands in vertebrate genomes

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12 December 2020

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

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12 December 2020

5' CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancer

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12 December 2020

Transforming and oncogenic potential of activated c-Ha-ras in three immortalized human breast epithelial cell lines

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12 December 2020

Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer

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12 December 2020

Epigenetic factors controlling the BRCA1 and BRCA2 genes in sporadic ovarian cancer.

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12 December 2020

Alterations in DNA methylation: a fundamental aspect of neoplasia

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12 December 2020

Transcriptional changes associated with breast cancer occur as normal human mammary epithelial cells overcome senescence barriers and become immortalized

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12 December 2020

Inactivation of glutathione S-transferase P1 gene by promoter hypermethylation in human neoplasia.

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12 December 2020

Epigenetic silencing of maspin gene expression in human breast cancers

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12 December 2020

Reduction of Cdc25A contributes to cyclin E1-Cdk2 inhibition at senescence in human mammary epithelial cells

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12 December 2020

CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation

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12 December 2020

Aberrant promoter methylation of the transcription factor genes PAX5 alpha and beta in human cancers.

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12 December 2020

Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in breast cancer

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12 December 2020

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

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12 December 2020

A somatic BRCA1 mutation in an ovarian tumour.

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12 December 2020

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

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12 December 2020

De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells

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12 December 2020

Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells

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12 December 2020

Loss of expression and aberrant methylation of the CDH13 (H-cadherin) gene in breast and lung carcinomas

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12 December 2020

Aberrant methylation of the Wnt antagonist SFRP1 in breast cancer is associated with unfavourable prognosis

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12 December 2020

Hypermethylation of the Wilms' tumor suppressor gene CpG island in human breast carcinomas

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12 December 2020

Downregulation of TSLC1 and DAL-1 expression occurs frequently in breast cancer

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12 December 2020

Do early premalignant changes in normal breast epithelial cells predict cancer development?

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12 December 2020

Tuberin and hamartin are aberrantly expressed and linked to clinical outcome in human breast cancer: the role of promoter methylation of TSC genes

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12 December 2020

Purification and unique properties of mammary epithelial stem cells

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12 December 2020

Frequency of germline and somatic BRCA1 mutations in ovarian cancer

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12 December 2020

Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes

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12 December 2020

Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development

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12 December 2020

Promoter hypomethylation of the N-acetyltransferase 1 gene in breast cancer.

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12 December 2020

P-cadherin overexpression is an indicator of clinical outcome in invasive breast carcinomas and is associated with CDH3 promoter hypomethylation.

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12 December 2020

Mutations of the BRCA1 gene in human cancer

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12 December 2020

Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene

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12 December 2020

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

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12 December 2020

CpG methylation as a basis for breast tumor-specific loss of NES1/kallikrein 10 expression.

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12 December 2020

CLCA2 tumour suppressor gene in 1p31 is epigenetically regulated in breast cancer.

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12 December 2020

Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells.

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12 December 2020

Generation of a functional mammary gland from a single stem cell

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12 December 2020

Overexpression of caveolin-1 and -2 in cell lines and in human samples of inflammatory breast cancer

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12 December 2020

Downregulation of human kallikrein 10 (KLK10/NES1) by CpG island hypermethylation in breast, ovarian and prostate cancers

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12 December 2020

Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer

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12 December 2020

LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer

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12 December 2020

Hypomethylation of the synuclein gamma gene CpG island promotes its aberrant expression in breast carcinoma and ovarian carcinoma

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12 December 2020

Isolation and characterization of the cDNA encoding human DNA methyltransferase

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12 December 2020

Hypermethylation-associated Inactivation of the Cellular Retinol-Binding-Protein 1 Gene in Human Cancer.

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12 December 2020

Methylation patterns of the E-cadherin 5' CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression

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12 December 2020

Aberrant methylation and silencing of ARHI, an imprinted tumor suppressor gene in which the function is lost in breast cancers.

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12 December 2020

RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer

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12 December 2020

A cell cycle regulator potentially involved in genesis of many tumor types

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12 December 2020

DNA hypomethylation is prevalent even in low-grade breast cancers

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12 December 2020

Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases

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12 December 2020

The fundamental role of epigenetic events in cancer

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12 December 2020

10.1007/S00109-008-0386-3

Identifiers

DOI

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19 August 2017

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PubMed ID

18716754