The superagonistic activity of bovine thyroid-stimulating hormone (TSH) and the human TR1401 TSH analog is determined by specific amino acids in the hinge region of the human TSH receptor (Q37269160)

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scientific article published on 22 April 2009

Language	Label	Description	Also known as
English	The superagonistic activity of bovine thyroid-stimulating hormone (TSH) and the human TR1401 TSH analog is determined by specific amino acids in the hinge region of the human TSH receptor	scientific article published on 22 April 2009

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

The superagonistic activity of bovine thyroid-stimulating hormone (TSH) and the human TR1401 TSH analog is determined by specific amino acids in the hinge region of the human TSH receptor (English)

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

author name string

Sandra Mueller

1

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Gunnar Kleinau

2

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Mariusz W Szkudlinski

3

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Holger Jaeschke

4

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Gerd Krause

5

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Ralf Paschke

6

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

language of work or name

0 references

publication date

22 April 2009

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

284

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

24

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

16317-16324

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Asp330 and Tyr331 in the C-terminal cysteine-rich region of the luteinizing hormone receptor are key residues in hormone-induced receptor activation

1 reference

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6 September 2017

The thyrotropin receptor hinge region is not simply a scaffold for the leucine-rich domain but contributes to ligand binding and signal transduction

1 reference

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6 September 2017

A functional transmembrane complex: the luteinizing hormone receptor with bound ligand and G protein.

1 reference

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6 September 2017

Structure of human follicle-stimulating hormone in complex with its receptor

1 reference

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6 September 2017

Model of glycoprotein hormone receptor ligand binding and signaling

1 reference

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Minireview: structural and functional evolution of the thyrotropin receptor

1 reference

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Thyroid-stimulating hormone receptor and its role in Graves' disease

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Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships

1 reference

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Thyrotropin receptor mutations as a tool to understand thyrotropin receptor action

1 reference

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Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors

1 reference

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6 September 2017

The role of the hinge region of the luteinizing hormone receptor in hormone interaction and signal generation

1 reference

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An elusive role for glycosylation in the structure and function of reproductive hormones

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6 September 2017

Identification of an important thyrotrophin binding site on the human thyrotrophin receptor using monoclonal antibodies

1 reference

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6 September 2017

Engineering human glycoprotein hormone superactive analogues

1 reference

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6 September 2017

Subunit-specific functions of N-linked oligosaccharides in human thyrotropin: role of terminal residues of alpha- and beta-subunit oligosaccharides in metabolic clearance and bioactivity

1 reference

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Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor

1 reference

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6 September 2017

Biological Activity and Metabolic Clearance of a Recombinant Human Thyrotropin Produced in Chinese Hamster Ovary Cells

1 reference

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6 September 2017

Critical involvement of the hinge region of the follicle-stimulating hormone receptor in the activation of the receptor

1 reference

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14 September 2017

A novel activating mutation in transmembrane helix 6 of the thyrotropin receptor as cause of hereditary nonautoimmune hyperthyroidism.

1 reference

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14 September 2017

Identification of a novel epitope in the thyroid-stimulating hormone receptor ectodomain acting as intramolecular signaling interface

1 reference

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14 September 2017

The ectodomain of the luteinizing hormone receptor interacts with exoloop 2 to constrain the transmembrane region: studies using chimeric human and fly receptors

1 reference

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28 September 2017

Significance of ectodomain cysteine boxes 2 and 3 for the activation mechanism of the thyroid-stimulating hormone receptor

1 reference

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26 June 2018

An aromatic environment in the vicinity of serine 281 is a structural requirement for thyrotropin receptor function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713536

26 June 2018

Activation of the luteinizing hormone receptor in the extracellular domain

1 reference

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Activation of the luteinizing hormone receptor following substitution of Ser-277 with selective hydrophobic residues in the ectodomain hinge region

1 reference

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Deletions in the third intracellular loop of the thyrotropin receptor. A new mechanism for constitutive activation

1 reference

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Determination of residues important in hormone binding to the extracellular domain of the luteinizing hormone/chorionic gonadotropin receptor by site-directed mutagenesis and modeling.

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Interpretation of binding curves obtained with high receptor concentrations: practical aid for computer analysis

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Further characterization of a high affinity thyrotropin binding site on the rat thyrotropin receptor which is an epitope for blocking antibodies from idiopathic myxedema patients but not thyroid stimulating antibodies from Graves' patients

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Site-directed mutagenesis of a portion of the extracellular domain of the rat thyrotropin receptor important in autoimmune thyroid disease and nonhomologous with gonadotropin receptors. Relationship of functional and immunogenic domains

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Binding assay for thyrotropin receptor autoantibodies using the recombinant receptor protein

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Thyroid stimulatory autoantibodies in different patients with autoimmune thyroid disease do not all recognize the same components of the human thyrotropin receptor: selective role of receptor amino acids Ser25-Glu30

1 reference

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26 June 2018

Extended hormone binding site of the human thyroid stimulating hormone receptor: distinctive acidic residues in the hinge region are involved in bovine thyroid stimulating hormone binding and receptor activation.

1 reference

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3 September 2018

Interactions between the extracellular domain and the extracellular loops as well as the 6th transmembrane domain are necessary for TSH receptor activation

1 reference

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3 September 2018

Human alpha-subunit analogs act as partial agonists to the thyroid-stimulating hormone receptor: differential effects of free and yoked subunits

1 reference

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A functional site on the human TSH receptor: a potential therapeutic target in Graves’ disease

1 reference

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3 September 2018

A full biological response to autoantibodies in Graves' disease requires a disulfide-bonded loop in the thyrotropin receptor N terminus homologous to a laminin epidermal growth factor-like domain

1 reference

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1 reference

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A novel germline mutation in the TSH receptor gene causes non-autoimmune autosomal dominant hyperthyroidism

1 reference

https://pubmed.ncbi.nlm.nih.gov/19386596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the thyrotropin binding pocket

1 reference

https://pubmed.ncbi.nlm.nih.gov/19386596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of binding of bovine and human thyroid-stimulating hormone to receptor sites on human thyroid membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19386596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for Species Specificity in the Interaction between Thyrotropin and Thyroid-Stimulating Immunoglobulin and Their Receptor in Thyroid Tissue*

1 reference

https://pubmed.ncbi.nlm.nih.gov/19386596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-function studies of the human thyrotropin receptor. Inhibition of binding of labeled thyrotropin (TSH) by synthetic human TSH receptor peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/19386596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thyrotropin (TSH) interacts with multiple discrete regions of the TSH receptor: polyclonal rabbit antibodies to one or more of these regions can inhibit TSH binding and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/19386596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High affinity binding of thyrotropin (TSH) and thyroid-stimulating autoantibody for the TSH receptor extracellular domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19386596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potent thyrotropic activity of human chorionic gonadotropin variants in terms of 125I incorporation and de novo synthesized thyroid hormone release in human thyroid follicles

1 reference

https://pubmed.ncbi.nlm.nih.gov/19386596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel, nonradioactive in vivo bioassay of thyrotropin (TSH)

1 reference

https://pubmed.ncbi.nlm.nih.gov/19386596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive activation of the TSH receptor by spontaneous mutations affecting the N‐terminal extracellular domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19386596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rational design strategy for protein hormone superagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/19386596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The alpha-subunit of human choriogonadotropin interacts with the exodomain of the luteinizing hormone/choriogonadotropin receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19386596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of follicle-stimulating hormone-selective beta-strands in the N-terminal hormone-binding exodomain of human gonadotropin receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19386596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural differences in the hinge region of the glycoprotein hormone receptors: evidence from the sulfated tyrosine residues

1 reference

https://pubmed.ncbi.nlm.nih.gov/19386596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.005710

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

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