WNT and beta-catenin signalling: diseases and therapies (Q29616159)

Europe PubMed Central

title

WNT and beta-catenin signalling: diseases and therapies (English)

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30 April 2017

author name string

Moon RT

1

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30 April 2017

Kohn AD

2

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30 April 2017

De Ferrari GV

3

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30 April 2017

Kaykas A

4

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=15372092

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language of work or name

1 reference

30 April 2017

publication date

September 2004

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30 April 2017

published in

Nature Reviews Genetics

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volume

5

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page(s)

691-701

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issue

9

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Mechanisms of Wnt signaling in development

30 April 2017

cites work

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Convergence of Wnt, beta-catenin, and cadherin pathways

1 May 2017

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1 May 2017

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GSK-3: tricks of the trade for a multi-tasking kinase

1 May 2017

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Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation

1 May 2017

1 reference

Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family

1 May 2017

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Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy

1 May 2017

1 reference

Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma

1 May 2017

1 reference

Wnt11 signaling promotes proliferation, transformation, and migration of IEC6 intestinal epithelial cells

1 May 2017

1 reference

The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia

1 May 2017

1 reference

Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1

1 May 2017

1 reference

Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy

1 May 2017

1 reference

Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q.

1 May 2017

1 reference

Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair

1 May 2017

1 reference

Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization

1 May 2017

1 reference

A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

1 May 2017

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High bone density due to a mutation in LDL-receptor-related protein 5

1 May 2017

1 reference

1 May 2017

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The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice

1 May 2017

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Lymphoid enhancer factor-1 and beta-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoter

1 May 2017

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The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

1 May 2017

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Illegitimate WNT signaling promotes proliferation of multiple myeloma cells

1 May 2017

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Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

1 May 2017

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FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1(-/-) mice

1 May 2017

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Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer

1 May 2017

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The tuberin-hamartin complex negatively regulates beta-catenin signaling activity

1 May 2017

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A common human skin tumour is caused by activating mutations in beta-catenin

1 May 2017

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Frizzled6 controls hair patterning in mice

1 May 2017

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beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis

1 May 2017

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Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm

1 May 2017

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 May 2017

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Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

1 May 2017

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Alzheimer's disease-do tauists and baptists finally shake hands?

1 May 2017

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Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils

1 May 2017

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GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

1 May 2017

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Sulindac targets nuclear beta-catenin accumulation and Wnt signalling in adenomas of patients with familial adenomatous polyposis and in human colorectal cancer cell lines

1 May 2017

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Regulation of cerebral cortical size by control of cell cycle exit in neural precursors

1 May 2017

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Inhibition of adipogenesis by Wnt signaling

1 May 2017

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Wnt2b controls retinal cell differentiation at the ciliary marginal zone

1 May 2017

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Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor

1 May 2017

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A role for Wnt signalling in self-renewal of haematopoietic stem cells

1 May 2017

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Wnt proteins are lipid-modified and can act as stem cell growth factors

1 May 2017

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Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a

1 May 2017

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Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

1 May 2017

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New aspects of Wnt signaling pathways in higher vertebrates

1 May 2017

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A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling

21 January 2018

1 reference

21 January 2018

Rethinking WNT signaling

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Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells

21 January 2018

1 reference

Downregulation of beta-catenin by p53 involves changes in the rate of beta-catenin phosphorylation and Axin dynamics.

21 January 2018

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The promise and perils of Wnt signaling through beta-catenin.

21 January 2018

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Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/beta-catenin activity.

21 January 2018

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Renal development: perspectives on a Wnt-dependent process

21 January 2018

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CNP gene expression is activated by Wnt signaling and correlates with Wnt4 expression during renal injury

21 January 2018

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The polycystic kidney disease-1 promoter is a target of the beta-catenin/T-cell factor pathway

21 January 2018

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Antisense wnt-5a mimics wnt-1-mediated C57MG mammary epithelial cell transformation

21 January 2018

1 reference

Increased expression of Wnt-1 in schizophrenic brains.

21 January 2018

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GSK-3 and the neurodevelopmental hypothesis of schizophrenia

21 January 2018

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Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females.

21 January 2018

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Frizzled 4 gene (FZD4) mutations in patients with familial exudative vitreoretinopathy with variable expressivity

21 January 2018

1 reference

Control of osteoblast function and regulation of bone mass

21 January 2018

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The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd.

21 January 2018

1 reference

Shutting down Wnt signal-activated cancer.

21 January 2018

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Caught up in a Wnt storm: Wnt signaling in cancer

21 January 2018

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Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression

21 January 2018

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Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis

21 January 2018

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Socializing with the neighbors: stem cells and their niche

21 January 2018

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Distinct Wnt members regulate the hierarchical morphogenesis of skin regions (spinal tract) and individual feathers

21 January 2018

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beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds

21 January 2018

1 reference

Growth factors regulate beta-catenin-mediated TCF-dependent transcriptional activation in fibroblasts during the proliferative phase of wound healing.

21 January 2018

1 reference

Beta-catenin expression in Dupuytren's disease: potential role for cell-matrix interactions in modulating beta-catenin levels in vivo and in vitro

21 January 2018

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Wnt signaling and pulmonary fibrosis

21 January 2018

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Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis

21 January 2018

1 reference

The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: recent challenges and their implications for novel drug development

21 January 2018

1 reference

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

21 January 2018

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Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex

21 January 2018

1 reference

Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis

21 January 2018

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The Wnt pathway, cell-cycle activation and beta-amyloid: novel therapeutic strategies in Alzheimer's disease?

21 January 2018

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Lithium protects cultured neurons against beta-amyloid-induced neurodegeneration.

21 January 2018

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Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100.

21 January 2018

1 reference

Sizing up the heart: development redux in disease.

21 January 2018

1 reference

A Wnt- and beta -catenin-dependent pathway for mammalian cardiac myogenesis

21 January 2018

1 reference

Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis

21 January 2018

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The wnt-frizzled cascade in cardiovascular disease

21 January 2018

1 reference

Reduction of infarct size and prevention of cardiac rupture in transgenic mice overexpressing FrzA.

21 January 2018

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Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex

21 January 2018

1 reference

A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells

21 January 2018

1 reference

Nitric oxide-donating aspirin inhibits β-catenin/T cell factor (TCF) signaling in SW480 colon cancer cells by disrupting the nuclear β-catenin–TCF association

21 January 2018

1 reference

Activation of the Wnt signaling pathway in chronic lymphocytic leukemia

21 January 2018

1 reference

Tyrosine kinase inhibitor STI-571/Gleevec down-regulates the β-catenin signaling activity

21 January 2018

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Morphogenesis of chicken liver: identification of localized growth zones and the role of beta-catenin/Wnt in size regulation

21 January 2018

1 reference

Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling

21 January 2018

1 reference

The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells

21 January 2018

1 reference

Wnt signaling induces the myogenic specification of resident CD45+ adult stem cells during muscle regeneration.

21 January 2018

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Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo.

21 January 2018

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Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1.

21 January 2018

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Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease.

21 January 2018

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Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells

21 January 2018

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Expression and Function of the Developmental Gene Wnt-4 during Experimental Acute Renal Failure in Rats

21 January 2018

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Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue

31 March 2020

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Linkage of a gene causing high bone mass to human chromosome 11 (11q12-13)

31 March 2020

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Wnt signaling function in Alzheimer's disease

31 March 2020

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Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase.

31 March 2020

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Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells.

31 March 2020

1 reference

Manipulating hematopoietic stem cell amplification with Wnt

31 March 2020

1 reference

Instructive role of Wnt/beta-catenin in sensory fate specification in neural crest stem cells

31 March 2020

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=15372092

31 March 2020

Identifiers

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30 April 2017

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

94415

1033736546

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94415

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Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=15372092

2 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017