Glucose sensing during hypoglycemia: lessons from the lab. (Q37269481)

19 August 2017

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Glucose sensing during hypoglycemia: lessons from the lab. (English)

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19 August 2017

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1 reference

Rory McCrimmon

1

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language of work or name

English

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publication date

1 August 2009

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19 August 2017

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19 August 2017

32

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19 August 2017

8

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19 August 2017

1357-1363

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

19 August 2017

start time

1 September 2021

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Increased GABAergic tone in the ventromedial hypothalamus contributes to suppression of counterregulatory responses after antecedent hypoglycemia

6 September 2017

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The mechanisms that underlie glucose sensing during hypoglycaemia in diabetes.

6 September 2017

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Ventromedial hypothalamic glucokinase is an important mediator of the counterregulatory response to insulin-induced hypoglycemia

6 September 2017

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Effect of acute and recurrent hypoglycemia on changes in brain glycogen concentration

6 September 2017

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AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons

6 September 2017

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Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia

6 September 2017

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Role of hypothalamic adenosine 5'-monophosphate-activated protein kinase in the impaired counterregulatory response induced by repetitive neuroglucopenia

6 September 2017

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Glucokinase is a critical regulator of ventromedial hypothalamic neuronal glucosensing

6 September 2017

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Regulation of glucagon secretion by glucose transporter type 2 (glut2) and astrocyte-dependent glucose sensors

6 September 2017

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Glucose-sensing neurons of the hypothalamus

6 September 2017

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CRF and CRF receptors: role in stress responsivity and other behaviors

6 September 2017

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Glucose-sensing neurons: are they physiologically relevant?

6 September 2017

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Glucokinase is the likely mediator of glucosensing in both glucose-excited and glucose-inhibited central neurons

6 September 2017

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6 September 2017

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Noradrenergic and GABAergic systems in the medial hypothalamus are activated during hypoglycemia

6 September 2017

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Extracellular glucose concentrations in the rat hippocampus measured by zero-net-flux: effects of microdialysis flow rate, strain, and age.

6 September 2017

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The AMP-activated protein kinase--fuel gauge of the mammalian cell?

6 September 2017

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Glucose-induced excitation of hypothalamic neurones is mediated by ATP-sensitive K+ channels

6 September 2017

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Activation of AMP-activated protein kinase within the ventromedial hypothalamus amplifies counterregulatory hormone responses in rats with defective counterregulation

6 September 2017

1 reference

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Activation of ATP-sensitive K+ channels in the ventromedial hypothalamus amplifies counterregulatory hormone responses to hypoglycemia in normal and recurrently hypoglycemic rats

14 September 2017

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Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats.

14 September 2017

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Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia.

14 September 2017

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Metabolism-independent sugar sensing in central orexin neurons.

14 September 2017

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Hypoglycemic detection at the portal vein is mediated by capsaicin-sensitive primary sensory neurons

26 June 2018

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Corticotrophin-releasing factor receptors within the ventromedial hypothalamus regulate hypoglycemia-induced hormonal counterregulation

26 June 2018

1 reference

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Striking differences in glucose and lactate levels between brain extracellular fluid and plasma in conscious human subjects: effects of hyperglycemia and hypoglycemia.

26 June 2018

1 reference

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Tolbutamide excites rat glucoreceptive ventromedial hypothalamic neurones by indirect inhibition of ATP-K+ channels

26 June 2018

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A role for central postsynaptic alpha 2-adrenoceptors in glucoregulation

26 June 2018

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The locus for hypoglycemic detection shifts with the rate of fall in glycemia: the role of portal-superior mesenteric vein glucose sensing

26 June 2018

1 reference

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Type 1 corticotropin-releasing factor receptors in the ventromedial hypothalamus promote hypoglycemia-induced hormonal counterregulation.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713634

Characterization of glucosensing neuron subpopulations in the arcuate nucleus: integration in neuropeptide Y and pro-opio melanocortin networks?

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713634

ATP-sensitive K(+) channels regulate the release of GABA in the ventromedial hypothalamus during hypoglycemia.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713634

Glucose, insulin, and leptin signaling pathways modulate nitric oxide synthesis in glucose-inhibited neurons in the ventromedial hypothalamus.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713634

Inhibition by glucose or leptin of hypothalamic neurons expressing neuropeptide Y requires changes in AMP-activated protein kinase activity.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713634

Recurrent hypoglycemia reduces the glucose sensitivity of glucose-inhibited neurons in the ventromedial hypothalamus nucleus.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713634

Blockade of GABA(A) receptors in the ventromedial hypothalamus further stimulates glucagon and sympathoadrenal but not the hypothalamo-pituitary-adrenal response to hypoglycemia.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713634

Hypoglycemia-induced noradrenergic activation in the VMH is a result of decreased ambient glucose

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713634

Hypothalamic ATP-sensitive K + channels play a key role in sensing hypoglycemia and triggering counterregulatory epinephrine and glucagon responses

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713634

Potential role for AMP-activated protein kinase in hypoglycemia sensing in the ventromedial hypothalamus

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713634

Physiological and molecular characteristics of rat hypothalamic ventromedial nucleus glucosensing neurons

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713634

Extracellular glucose in rat ventromedial hypothalamus during acute and recurrent hypoglycemia

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713634

Hypothalamic ependymal-glial cells express the glucose transporter GLUT2, a protein involved in glucose sensing

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713634

Effect of hypoglycemia on brain glycogen metabolism in vivo

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713634

Local lactate perfusion of the ventromedial hypothalamus suppresses hypoglycemic counterregulation

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713634

Dynamic imaging of free cytosolic ATP concentration during fuel sensing by rat hypothalamic neurones: evidence for ATP-independent control of ATP-sensitive K(+) channels

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713634

Convergence of pre- and postsynaptic influences on glucosensing neurons in the ventromedial hypothalamic nucleus

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713634

ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713634

Parasympathetic and sympathetic control of the pancreas: a role for the suprachiasmatic nucleus and other hypothalamic centers that are involved in the regulation of food intake.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713634

Hypothalamic glucose sensor: similarities to and differences from pancreatic beta-cell mechanisms.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713634

Glucose generates sub-plasma membrane ATP microdomains in single islet beta-cells. Potential role for strategically located mitochondria.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713634

Glucose and osmosensitive neurones of the rat hypothalamus.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713634

Risk of hypoglycaemia in types 1 and 2 diabetes: effects of treatment modalities and their duration

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713634

Localization of hindbrain glucoreceptive sites controlling food intake and blood glucose

3 December 2018

1 reference

12 December 2020

Norepinephrine mediates glucoprivic-induced increase in GABA in the ventromedial hypothalamus of rats

1 reference

12 December 2020

Regulation of Astrocyte Energy Metabolism by Neurotransmitters

1 reference

12 December 2020

Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release

1 reference

12 December 2020

Hypoglycemia unawareness in IDDM

1 reference

12 December 2020

Identifiers

DOI

10.2337/DC09-0123

1 reference

19 August 2017

1 reference

19 August 2017

1 reference

PMCID

2713634