Synergy of radiotherapy and PD-1 blockade in Kras-mutant lung cancer. (Q37277324)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27699275%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

title

Synergy of radiotherapy and PD-1 blockade in Kras-mutant lung cancer (English)

1 reference

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adaptive radiation therapy

24 March 2020

main subject

0 references

author

Josephine Hai

4

1 reference

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24 March 2020

Jiehui Deng

5

1 reference

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24 March 2020

16

F Stephen Hodi

1 reference

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24 March 2020

17

Gordon J Freeman

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24 March 2020

author name string

Grit S Herter-Sprie

1

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24 March 2020

Shohei Koyama

2

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24 March 2020

Houari Korideck

3

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24 March 2020

Yvonne Y Li

6

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24 March 2020

Kevin A Buczkowski

7

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24 March 2020

Aaron K Grant

8

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24 March 2020

Soumya Ullas

9

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24 March 2020

Kevin Rhee

10

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24 March 2020

Jillian D Cavanaugh

11

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24 March 2020

Neermala Poudel Neupane

12

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24 March 2020

Camilla L Christensen

13

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24 March 2020

Jan M Herter

14

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24 March 2020

G Mike Makrigiorgos

15

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24 March 2020

Glenn Dranoff

18

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24 March 2020

Peter S Hammerman

19

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24 March 2020

Alec C Kimmelman

20

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24 March 2020

Kwok-Kin Wong

21

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24 March 2020

publication date

16 June 2016

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24 March 2020

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24 March 2020

volume

1

1 reference

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24 March 2020

issue

9

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24 March 2020

page(s)

e87415

1 reference

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STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment.

24 March 2020

cites work

1 reference

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9 September 2017

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Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities

9 September 2017

1 reference

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Modulation of inflammation by low and high doses of ionizing radiation: Implications for benign and malign diseases

9 September 2017

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The abscopal effect of local radiotherapy: using immunotherapy to make a rare event clinically relevant

9 September 2017

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Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

9 September 2017

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9 September 2017

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Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

9 September 2017

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Immunohistochemical Loss of LKB1 Is a Biomarker for More Aggressive Biology in KRAS-Mutant Lung Adenocarcinoma.

9 September 2017

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Image-guided radiotherapy platform using single nodule conditional lung cancer mouse models

9 September 2017

1 reference

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Myeloid-derived cells in tumors: effects of radiation

9 September 2017

1 reference

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Alterations of LKB1 and KRAS and risk of brain metastasis: comprehensive characterization by mutation analysis, copy number, and gene expression in non-small-cell lung carcinoma.

9 September 2017

1 reference

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9 September 2017

Cancer statistics, 2014

1 reference

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Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice.

9 September 2017

1 reference

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KIT oncogene inhibition drives intratumoral macrophage M2 polarization.

9 September 2017

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Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy

9 September 2017

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Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors

9 September 2017

1 reference

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Combined treatment effects of radiation and immunotherapy: studies in an autochthonous prostate cancer model

9 September 2017

1 reference

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Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma

9 September 2017

1 reference

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Developing a common language for tumor response to immunotherapy: immune-related response criteria using unidimensional measurements

9 September 2017

1 reference

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Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung

9 September 2017

1 reference

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Assessing the radiation response of lung cancer with different gene mutations using genetically engineered mice.

9 September 2017

1 reference

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Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis

9 September 2017

1 reference

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Irradiation promotes an m2 macrophage phenotype in tumor hypoxia.

9 September 2017

1 reference

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Expression of NF-κB p50 in tumor stroma limits the control of tumors by radiation therapy

9 September 2017

1 reference

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Safety, activity, and immune correlates of anti-PD-1 antibody in cancer

9 September 2017

1 reference

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The abscopal effect associated with a systemic anti-melanoma immune response

9 September 2017

1 reference

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Personalized tumor response assessment in the era of molecular medicine: cancer-specific and therapy-specific response criteria to complement pitfalls of RECIST

9 September 2017

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A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response

9 September 2017

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Immunologic correlates of the abscopal effect in a patient with melanoma

9 September 2017

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Human monocytes are severely impaired in base and DNA double-strand break repair that renders them vulnerable to oxidative stress

9 September 2017

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Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer

9 September 2017

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Infiltrating macrophages in extratumoural tissues after brachytherapy of uveal melanoma

9 September 2017

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Non-germline genetically engineered mouse models for translational cancer research

9 September 2017

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Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

9 September 2017

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Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates

9 September 2017

1 reference

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Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small-cell lung cancer.

9 September 2017

1 reference

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Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice.

9 September 2017

1 reference

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Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria

9 September 2017

1 reference

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Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody

9 September 2017

1 reference

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Somatic mutations affect key pathways in lung adenocarcinoma

9 September 2017

1 reference

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Docetaxel-induced interstitial pneumonitis following non-small-cell lung cancer treatment

9 September 2017

1 reference

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Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors

9 September 2017

1 reference

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LKB1 modulates lung cancer differentiation and metastasis

9 September 2017

1 reference

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Full restoration of peripheral Foxp3+ regulatory T cell pool by radioresistant host cells in scurfy bone marrow chimeras

9 September 2017

1 reference

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Type, density, and location of immune cells within human colorectal tumors predict clinical outcome

9 September 2017

1 reference

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Restoring function in exhausted CD8 T cells during chronic viral infection

9 September 2017

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Radiation and the microenvironment - tumorigenesis and therapy

9 September 2017

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Alveolar macrophages regulate neutrophil recruitment in endotoxin-induced lung injury

9 September 2017

1 reference

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Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

9 September 2017

1 reference

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Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer

9 September 2017

1 reference

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Radiotherapy augments the immune response to prostate cancer in a time-dependent manner

9 September 2017

1 reference

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Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5033933

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

14 September 2017

1 reference

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Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

14 September 2017

1 reference

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Fas regulates neutrophil lifespan during viral and bacterial infection

28 September 2017

1 reference

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Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell death

26 June 2018

1 reference

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The biologic importance of tumor-infiltrating lymphocytes

26 June 2018

1 reference

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Is classical stereotactic radiotherapy the optimal partner for immunotherapy?

26 June 2018

1 reference

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Eosinophils orchestrate cancer rejection by normalizing tumor vessels and enhancing infiltration of CD8(+) T cells.

3 September 2018

1 reference

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Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD-L1 blockade.

3 September 2018

1 reference

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An abscopal response to radiation and ipilimumab in a patient with metastatic non-small cell lung cancer.

3 September 2018

1 reference

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Low-dose irradiation programs macrophage differentiation to an iNOS⁺/M1 phenotype that orchestrates effective T cell immunotherapy

3 September 2018

1 reference

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Tumor-infiltrating CD8+ lymphocytes predict clinical outcome in breast cancer.

3 September 2018

1 reference

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Differential effects of irradiation with carbon ions and x-rays on macrophage function

3 September 2018

1 reference

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Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection.

3 September 2018

1 reference

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The role of microglia/macrophage system in the tissue response to I-125 interstitial brachytherapy of cerebral gliomas

3 September 2018

1 reference

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Analysis of the response and toxicity to gefitinib of non-small cell lung cancer.

3 September 2018

1 reference

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Abscopal Effects after Conventional and Stereotactic Lung Irradiation of Non–Small-Cell Lung Cancer

3 September 2018

1 reference

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Radiological and Clinical Pneumonitis After Stereotactic Lung Radiotherapy: A Matched Analysis of Three-Dimensional Conformal and Volumetric-modulated Arc Therapy Techniques

3 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27699275

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI.INSIGHT.87415

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27699275%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27699275%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

PubMed publication ID

27699275

1 reference