Disruption of E-cadherin by matrix metalloproteinase directly mediates epithelial-mesenchymal transition downstream of transforming growth factor-beta1 in renal tubular epithelial cells. (Q37278443)

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scientific article published on 09 July 2009

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English	Disruption of E-cadherin by matrix metalloproteinase directly mediates epithelial-mesenchymal transition downstream of transforming growth factor-beta1 in renal tubular epithelial cells.	scientific article published on 09 July 2009

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Disruption of E-cadherin by matrix metalloproteinase directly mediates epithelial-mesenchymal transition downstream of transforming growth factor-beta1 in renal tubular epithelial cells (English)

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Guoping Zheng

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Thian Kui Tan

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Yiping Wang

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Tzu-Ting Hsu

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Lena Succar

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Gopala K Rangan

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Min Hu

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Beric R Henderson

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Stephen I Alexander

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David C H Harris

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Tubular epithelial cell dedifferentiation is driven by the helix-loop-helix transcriptional inhibitor Id1.

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Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney

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Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix

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Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells

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Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways

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Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability

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The transcription factor Snail downregulates the tight junction components independently of E-cadherin downregulation

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6 September 2017

Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention

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Epithelial-mesenchymal transition and its implications for fibrosis

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6 September 2017

Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK

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Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy

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Evidence that fibroblasts derive from epithelium during tissue fibrosis

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Cloning and characterization of three Xenopus slug promoters reveal direct regulation by Lef/beta-catenin signaling.

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Transcriptional regulation by Smads: crosstalk between the TGF-beta and Wnt pathways

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The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression

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E-Cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27(KIP1)

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Matrix metalloproteinase(s) mediate(s) NO-induced dissociation of beta-catenin from membrane bound E-cadherin and formation of nuclear beta-catenin/LEF-1 complex.

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Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity

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Twisted epithelial-mesenchymal transition blocks senescence

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12 December 2020

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E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation

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https://pubmed.ncbi.nlm.nih.gov/19590041

12 December 2020

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10.2353/AJPATH.2009.080983

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2 February 2020

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2 February 2020

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