Activin signaling targeted by insulin/dFOXO regulates aging and muscle proteostasis in Drosophila (Q37289065)

19 August 2017

Activin signaling targeted by insulin/dFOXO regulates aging and muscle proteostasis in Drosophila (English)

1 reference

19 August 2017

0 references

1 reference

Glycogen phosphorylase Dmel_CG7254

1 reference

Forkhead box, sub-group O Dmel_CG3143

1 reference

Tetraspanin 42Ef Dmel_CG12845

1 reference

Smad on X Dmel_CG2262

1 reference

1 reference

Hua Bai

1

0 references

Marc Tatar

object named as

Marc Tatar

series ordinal

4

0 references

author name string

Ping Kang

series ordinal

2

1 reference

PMCID

3820802

19 August 2017

Ana Maria Hernandez

series ordinal

3

1 reference

19 August 2017

7 November 2013

1 reference

19 August 2017

1 reference

19 August 2017

9

1 reference

19 August 2017

e1003941

1 reference

19 August 2017

11

1 reference

Creative Commons Attribution 4.0 International

19 August 2017

start time

7 November 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3820802/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain

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Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster

6 September 2017

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Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling

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PDP-1 links the TGF-β and IIS pathways to regulate longevity, development, and metabolism

6 September 2017

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Insulin receptor substrate chico acts with the transcription factor FOXO to extend Drosophila lifespan

6 September 2017

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dFOXO-independent effects of reduced insulin-like signaling in Drosophila

6 September 2017

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TGF-β and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance

6 September 2017

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TGF-{beta}1 protects against mesangial cell apoptosis via induction of autophagy

6 September 2017

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DamID in C. elegans reveals longevity-associated targets of DAF-16/FoxO

6 September 2017

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Partial ablation of adult Drosophila insulin-producing neurons modulates glucose homeostasis and extends life span without insulin resistance

6 September 2017

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6 September 2017

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Molecular evolution and functional characterization of Drosophila insulin-like peptides

6 September 2017

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Autophagy takes flight in Drosophila

6 September 2017

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A Drosophila insulin-like peptide promotes growth during nonfeeding states

6 September 2017

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TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging

6 September 2017

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Informatics approaches to understanding TGFbeta pathway regulation.

6 September 2017

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MEME SUITE: tools for motif discovery and searching

6 September 2017

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Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

6 September 2017

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Association of FOXO3A variation with human longevity confirmed in German centenarians

6 September 2017

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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

6 September 2017

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PeakSeq enables systematic scoring of ChIP-seq experiments relative to controls

6 September 2017

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6 September 2017

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FOXO3A genotype is strongly associated with human longevity

6 September 2017

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A role for autophagy in the extension of lifespan by dietary restriction in C. elegans

6 September 2017

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FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells

6 September 2017

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TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility

6 September 2017

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The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling

6 September 2017

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Brain IRS2 signaling coordinates life span and nutrient homeostasis

6 September 2017

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Chromatin immunoprecipitation and microarray-based analysis of protein location

6 September 2017

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Protein turnover via autophagy: implications for metabolism

6 September 2017

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The stress of misfolded proteins: C. elegans models for neurodegenerative disease and aging

6 September 2017

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The roles of intracellular protein-degradation pathways in neurodegeneration

6 September 2017

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Autophagy and aging: the importance of maintaining "clean" cells

6 September 2017

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6 September 2017

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JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling

6 September 2017

1 reference

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Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

Autophagy genes are essential for dauer development and life-span extension in C. elegans

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

The endocrine regulation of aging by insulin-like signals

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

Extended longevity in mice lacking the insulin receptor in adipose tissue

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

Inhibins, activins and follistatin in reproduction

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

P[Switch], a system for spatial and temporal control of gene expression in Drosophila melanogaster

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

Human Smad3 and Smad4 are sequence-specific transcription activators

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

A C. elegans mutant that lives twice as long as wild type

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

The BMP-binding protein Crossveinless 2 is a short-range, concentration-dependent, biphasic modulator of BMP signaling in Drosophila.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

The Drosophila Activin-like ligand Dawdle signals preferentially through one isoform of the Type-I receptor Baboon

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

The steroid hormone receptor EcR finely modulates Drosophila lifespan during adulthood in a sex-specific manner.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

Cell death during Drosophila melanogaster early oogenesis is mediated through autophagy.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

Drosophila Activin- and the Activin-like product Dawdle function redundantly to regulate proliferation in the larval brain

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

Differential in vivo requirements for oligomerization during Groucho-mediated repression

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

ChIP-on-chip protocol for genome-wide analysis of transcription factor binding in Drosophila melanogaster embryos.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

The divergent TGF-beta ligand Dawdle utilizes an activin pathway to influence axon guidance in Drosophila

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

The metalloprotease tolloid-related and its TGF-beta-like substrate Dawdle regulate Drosophila motoneuron axon guidance

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

Distinct behavioral responses to ethanol are regulated by alternate RhoGAP18B isoforms

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

Insulin regulation of heart function in aging fruit flies

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

Long-lived Drosophila with overexpressed dFOXO in adult fat body

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

The demography of slow aging in male and female Drosophila mutant for the insulin-receptor substrate homologue chico.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

The Drosophila bZIP transcription factor Vrille is involved in hair and cell growth

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

DAF-16 target genes that control C. elegans life-span and metabolism.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

The Drosophila BMP type II receptor Wishful Thinking regulates neuromuscular synapse morphology and function

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

Thorax closure in Drosophila: involvement of Fos and the JNK pathway.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820802

10.1371/JOURNAL.PGEN.1003941

3 September 2018

Identifiers

DOI

1 reference

19 August 2017

1 reference

19 August 2017

1 reference

PMCID

3820802