The roles of intracellular protein-degradation pathways in neurodegeneration (Q28269322)

Toxic proteins in neurodegenerative disease

Europe PubMed Central

title

The roles of intracellular protein-degradation pathways in neurodegeneration (English)

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author name string

David C Rubinsztein

series ordinal

1

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language of work or name

English

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publication date

19 October 2006

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published in

Nature

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volume

443

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page(s)

780-6

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issue

7113

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cites work

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Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity

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Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

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Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

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α-Synuclein Is Degraded by Both Autophagy and the Proteasome

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Aggregate formation inhibits proteasomal degradation of polyglutamine proteins.

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Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins

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Caspase activation inhibits proteasome function during apoptosis

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Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

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Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

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A motor neuron disease-associated mutation in p150Glued perturbs dynactin function and induces protein aggregation

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Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

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Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

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Identifiers

DOI

10.1038/NATURE05291

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

487417

1027447909

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487417

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference