The AKT inhibitor MK-2206 is cytotoxic in hepatocarcinoma cells displaying hyperphosphorylated AKT-1 and synergizes with conventional chemotherapy (Q37299276)

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scientific article published on September 2013

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English	The AKT inhibitor MK-2206 is cytotoxic in hepatocarcinoma cells displaying hyperphosphorylated AKT-1 and synergizes with conventional chemotherapy	scientific article published on September 2013

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scholarly article

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Europe PubMed Central

PMC publication ID

19 August 2017

The AKT inhibitor MK-2206 is cytotoxic in hepatocarcinoma cells displaying hyperphosphorylated AKT-1 and synergizes with conventional chemotherapy (English)

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Europe PubMed Central

PMC publication ID

19 August 2017

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13 June 2020

Silvano Capitani

6

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13 June 2020

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Carolina Simioni

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13 June 2020

Alberto M Martelli

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13 June 2020

James A McCubrey

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13 June 2020

Luca M Neri

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13 June 2020

Rengul Cetin-Atalay

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13 June 2020

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publication date

1 September 2013

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19 August 2017

full work available at URL

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824526

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13 June 2020

4

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13 June 2020

9

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13 June 2020

1496-1506

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13 June 2020

Nilotinib induces autophagy in hepatocellular carcinoma through AMPK activation

1 reference

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6 September 2017

Activity of the mTOR inhibitor RAD001, the dual mTOR and PI3-kinase inhibitor BEZ235 and the PI3-kinase inhibitor BKM120 in hepatocellular carcinoma

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Advances in targeting signal transduction pathways

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A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia

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Combined targeting of AKT and mTOR synergistically inhibits proliferation of hepatocellular carcinoma cells

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Glyceraldehyde-3-phosphate dehydrogenase: a promising target for molecular therapy in hepatocellular carcinoma

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Harnessing the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia: eliminating activity by targeting at different levels

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The response to PAK1 inhibitor IPA3 distinguishes between cancer cells with mutations in BRAF and Ras oncogenes

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Molecular mechanisms of sorafenib action in liver cancer cells.

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6 September 2017

Activity of the selective IκB kinase inhibitor BMS-345541 against T-cell acute lymphoblastic leukemia: involvement of FOXO3a

1 reference

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6 September 2017

Cytotoxic activity of the novel Akt inhibitor, MK-2206, in T-cell acute lymphoblastic leukemia.

1 reference

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6 September 2017

Targeted therapy for hepatocellular carcinoma: novel agents on the horizon

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6 September 2017

Therapeutic potential of MEK inhibition in acute myelogenous leukemia: rationale for "vertical" and "lateral" combination strategies

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Targeting autophagy addiction in cancer

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Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop.

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MK-2206, a novel allosteric inhibitor of Akt, synergizes with gefitinib against malignant glioma via modulating both autophagy and apoptosis

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6 September 2017

Are there opportunities for chemotherapy in the treatment of hepatocellular cancer?

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Hormesis, cell death and aging

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Cooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells

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Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells

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Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma

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Potential therapeutic strategies to overcome acquired resistance to BRAF or MEK inhibitors in BRAF mutant cancers

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Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

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Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health

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Pancreatic cancers require autophagy for tumor growth

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Tyrosine kinase inhibitors to treat liver cancer

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Beyond apoptosis of JNK1 in liver cancer

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Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

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The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications

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Deregulation of the Akt pathway in human cancer

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Expression of PTEN, PPM1A and P-Smad2 in hepatocellular carcinomas and adjacent liver tissues

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Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma

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The two TORCs and Akt.

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13 June 2020

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13 June 2020

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