The role of FXR in disorders of bile acid homeostasis (Q37300843)

19 August 2017

1 reference

title

The role of FXR in disorders of bile acid homeostasis (English)

1 reference

19 August 2017

Jyrki J Eloranta

1

1 reference

PubMed ID

18927204

19 August 2017

Gerd A Kullak-Ublick

series ordinal

2

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19 August 2017

1 October 2008

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19 August 2017

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19 August 2017

23

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19 August 2017

286-295

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Reduced hepatic expression of farnesoid X receptor in hereditary cholestasis associated to mutation in ATP8B1

19 August 2017

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Syndecan-1 expression is regulated in an isoform-specific manner by the farnesoid-X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Decreased hepatic expression of PPAR-gamma coactivator-1 in cholesterol cholelithiasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Hepatic insulin resistance directly promotes formation of cholesterol gallstones

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Stigmasterol, a soy lipid-derived phytosterol, is an antagonist of the bile acid nuclear receptor FXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Progressive familial intrahepatic cholestasis, type 1, is associated with decreased farnesoid X receptor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

The amino acid residues asparagine 354 and isoleucine 372 of human farnesoid X receptor confer the receptor with high sensitivity to chenodeoxycholate

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: evidence for a defect in protein trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

The human Na+-taurocholate cotransporting polypeptide gene is activated by glucocorticoid receptor and peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and suppressed by bile acids via a small heterodimer partner-dependent mechan

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangioles

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Identification of a nuclear receptor that is activated by farnesol metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Overview of nomenclature of nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Principles for modulation of the nuclear receptor superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Angiogenins: a new class of microbicidal proteins involved in innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Farnesoid X Receptor Activates Transcription of the Phospholipid Pump MDR3

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Genetic cholestasis, causes and consequences for hepatobiliary transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

The orphan nuclear receptor SHP utilizes conserved LXXLL-related motifs for interactions with ligand-activated estrogen receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Characterization of the human OATP-C (SLC21A6) gene promoter and regulation of liver-specific OATP genes by hepatocyte nuclear factor 1 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Hepatocyte nuclear factor 1 alpha: a key mediator of the effect of bile acids on gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

The nuclear bile acid receptor FXR is activated by PGC-1alpha in a ligand-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

A G protein-coupled receptor responsive to bile acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Role of an mSin3A-Swi/Snf chromatin remodeling complex in the feedback repression of bile acid biosynthesis by SHP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Variation of the gene encoding the nuclear bile salt receptor FXR and gallstone susceptibility in mice and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Enterohepatic bile salt transporters in normal physiology and liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

The farnesoid X receptor controls gene expression in a ligand- and promoter-selective fashion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Identification of a nuclear receptor for bile acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Identification of a chemical tool for the orphan nuclear receptor FXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Impact of genetic variation of PPARgamma in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Prevention of cholesterol gallstone disease by FXR agonists in a mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

ATP8B1 mutations in British cases with intrahepatic cholestasis of pregnancy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Regulation of bile acid synthesis under reconstructed enterohepatic circulation in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Inducible nitric oxide synthase: what difference does it make?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Bile acid-induced negative feedback regulation of the human ileal bile acid transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Sequence variation in the ATP8B1 gene and intrahepatic cholestasis of pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Bile acids: natural ligands for an orphan nuclear receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Linkage between a new splicing site mutation in the MDR3 alias ABCB4 gene and intrahepatic cholestasis of pregnancy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Coregulator function: a key to understanding tissue specificity of selective receptor modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

The bile salt export pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Association between the PPARA L162V polymorphism and plasma lipid levels: the Framingham Offspring Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Coffee consumption and death from coronary heart disease in middle aged Norwegian men and women

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Vitamin D receptor polymorphisms and diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

FIC1 disease: a spectrum of intrahepatic cholestatic disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Nitric oxide in mucosal defense: a little goes a long way.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Endogenous bile acids are ligands for the nuclear receptor FXR/BAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Redundant pathways for negative feedback regulation of bile acid production

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

The nuclear hormone receptor farnesoid X receptor (FXR) is activated by androsterone

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Effects of bile salt flux variations on the expression of hepatic bile salt transporters in vivo in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Activation of the orphan receptor RIP14 by retinoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00020.2008

10.1152/PHYSIOL.00020.2008

21 January 2018

Identifiers

DOI

1 reference

19 August 2017

1 reference

PubMed ID

18927204