Targeting excitotoxic/free radical signaling pathways for therapeutic intervention in glaucoma (Q37301646)

19 August 2017

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title

Targeting excitotoxic/free radical signaling pathways for therapeutic intervention in glaucoma (English)

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19 August 2017

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Masaaki Seki

1

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19 August 2017

Stuart A Lipton

series ordinal

2

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19 August 2017

publication date

1 January 2008

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Progress in Brain Research

19 August 2017

published in

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19 August 2017

volume

173

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19 August 2017

page(s)

495-510

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Responses mediated by excitatory amino acid receptors in solitary retinal ganglion cells from rat

19 August 2017

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Enhanced vulnerability to NMDA toxicity in sublethal traumatic neuronal injury in vitro

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Modulation of non-vesicular glutamate release by pH

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Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures

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Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels

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7 January 2021

Expression of NMDA and high-affinity kainate receptor subunit mRNAs in the adult rat retina

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7 January 2021

The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage

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The PSD95-nNOS interface: a target for inhibition of excitotoxic p38 stress-activated protein kinase activation and cell death

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7 January 2021

Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism

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7 January 2021

The chemical biology of clinically tolerated NMDA receptor antagonists

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7 January 2021

Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity

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7 January 2021

Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation

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7 January 2021

Glutamate neurotoxicity and diseases of the nervous system

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7 January 2021

Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation

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7 January 2021

PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain

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7 January 2021

Nitric oxide neurotoxicity

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7 January 2021

Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures.

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7 January 2021

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures

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7 January 2021

New perspectives on glaucoma

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7 January 2021

Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma

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7 January 2021

Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite

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7 January 2021

Optic nerve blood-flow abnormalities in glaucoma

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7 January 2021

Reduction of voltage-dependent magnesium block of N-methyl-D-aspartate receptor-mediated current by in vivo axonal injury

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7 January 2021

Blockade of PARP activity attenuates poly(ADP-ribosyl)ation but offers only partial neuroprotection against NMDA-induced cell death in the rat retina

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7 January 2021

Mitochondria and apoptosis

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7 January 2021

Alteration in the voltage dependence of NMDA receptor channels in rat dorsal horn neurones following peripheral inflammation

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7 January 2021

Central mammalian neurons normally resistant to glutamate toxicity are made sensitive by elevated extracellular Ca2+: toxicity is blocked by the N-methyl-D-aspartate antagonist MK-801

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7 January 2021

The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma

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7 January 2021

The Yin and Yang of NMDA receptor signalling

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7 January 2021

Efficacy and safety of memantine treatment for reduction of changes associated with experimental glaucoma in monkey, I: Functional measures

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https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2901134-5

7 January 2021

Efficacy and safety of memantine, an NMDA-type open-channel blocker, for reduction of retinal injury associated with experimental glaucoma in rat and monkey

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7 January 2021

Efficacy and safety of memantine treatment for reduction of changes associated with experimental glaucoma in monkey, II: Structural measures

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7 January 2021

Localization and developmental expression of the NMDA receptor subunit NR2A in the mammalian retina.

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7 January 2021

Protein S-nitrosylation: purview and parameters

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7 January 2021

Vitreous amino acid concentrations in patients with glaucoma undergoing vitrectomy.

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7 January 2021

Recent advances in the phencyclidine model of schizophrenia

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7 January 2021

Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells

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7 January 2021

Role of p38 mitogen-activated protein kinase in axotomy-induced apoptosis of rat retinal ganglion cells.

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7 January 2021

Prevalence of glaucoma. The Beaver Dam Eye Study.

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7 January 2021

Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95

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7 January 2021

NMDA-dependent superoxide production and neurotoxicity

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7 January 2021

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

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7 January 2021

Novel injury mechanism in anoxia and trauma of spinal cord white matter: glutamate release via reverse Na+-dependent glutamate transport.

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7 January 2021

Prospects for clinically tolerated NMDA antagonists: open-channel blockers and alternative redox states of nitric oxide

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7 January 2021

Neuronal protection and destruction by NO.

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7 January 2021

Possible role for memantine in protecting retinal ganglion cells from glaucomatous damage

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7 January 2021

Failures and successes of NMDA receptor antagonists: molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults

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7 January 2021

Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond

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7 January 2021

Pathologically activated therapeutics for neuroprotection

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7 January 2021

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2901134-5

7 January 2021

Excitatory amino acids as a final common pathway for neurologic disorders.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2901134-5

7 January 2021

The toxic effect of sodium L-glutamate on the inner layers of the retina.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2901134-5

7 January 2021

Divergent NMDA signals leading to proapoptotic and antiapoptotic pathways in the rat retina

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https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2901134-5

7 January 2021

Neuronal activity-dependent cell survival mediated by transcription factor MEF2

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https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2901134-5

7 January 2021

Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones

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https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2901134-5

7 January 2021

Clinical experience with excitatory amino acid antagonist drugs

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https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2901134-5

7 January 2021

S-Nitrosylation and uncompetitive/fast off-rate (UFO) drug therapy in neurodegenerative disorders of protein misfolding

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https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2901134-5

7 January 2021

Magnesium gates glutamate-activated channels in mouse central neurones

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https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2901134-5

7 January 2021

Antiapoptotic role of the p38 mitogen-activated protein kinase-myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation

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https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2901134-5

7 January 2021

Brain damage in infant mice following oral intake of glutamate, aspartate or cysteine

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https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2901134-5

7 January 2021

Efficacy and safety of memantine in patients with mild to moderate vascular dementia: a randomized, placebo-controlled trial (MMM 300).

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https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2901134-5

7 January 2021

Memantine reduces alterations to the mammalian retina, in situ, induced by ischemia

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https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2901134-5

7 January 2021

A hypothesis to explain ganglion cell death caused by vascular insults at the optic nerve head: possible implication for the treatment of glaucoma

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7 January 2021

Open label, multicenter, 28-week extension study of the safety and tolerability of memantine in patients with mild to moderate Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2901134-5

7 January 2021

Ganglion cell death in glaucoma: pathology recapitulates ontogeny

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2901134-5

7 January 2021

Neuronal death in glaucoma

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2901134-5

7 January 2021

Memantine in moderate-to-severe Alzheimer's disease

1 reference

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7 January 2021

A 24-week open-label extension study of memantine in moderate to severe Alzheimer disease

1 reference

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7 January 2021

Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2901134-5

7 January 2021

Memantine and HIV-associated cognitive impairment: a neuropsychological and proton magnetic resonance spectroscopy study.

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https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2901134-5

7 January 2021

Rho mediates calcium-dependent activation of p38alpha and subsequent excitotoxic cell death

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7 January 2021

N-methyl-D-aspartate antagonists prevent kainate neurotoxicity in rat retinal ganglion cells in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2901134-5

7 January 2021

Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2901134-5

7 January 2021

Triggering and execution of neuronal death in brain ischaemia: two phases of glutamate release by different mechanisms

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7 January 2021

The immune system and glaucoma

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7 January 2021

The contrasting roles of ICE family proteases and interleukin-1beta in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2901134-5

7 January 2021

Glutamate levels in aqueous humor of patients with retinal artery occlusion

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2901134-5

7 January 2021

A double-blind, placebo-controlled multicentre study of memantine in mild to moderate vascular dementia (MMM500).

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7 January 2021

The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase

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7 January 2021

Neuroprotective effect of memantine in different retinal injury models in rats

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7 January 2021

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

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7 January 2021

Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death

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7 January 2021

Poly(ADP-ribose) polymerase-1 and apoptosis inducing factor in neurotoxicity

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https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2901134-5

7 January 2021

Memantine protects neurons from shrinkage in the lateral geniculate nucleus in experimental glaucoma

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2901134-5

7 January 2021

Evidence that the loss of the voltage-dependent Mg2+ block at the N-methyl-D-aspartate receptor underlies receptor activation during inhibition of neuronal metabolism

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https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2901134-5

7 January 2021

Reduction of voltage-dependent Mg2+ blockade of NMDA current in mechanically injured neurons

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https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2901134-5

7 January 2021

Nitrate therapy may retard glaucomatous optic neuropathy, perhaps through modulation of glutamate receptors

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https://api.crossref.org/works/10.1016%2FS0079-6123%2808%2901134-5

7 January 2021

10.1016/S0079-6123(08)01134-5

Identifiers

DOI

1 reference

19 August 2017

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