Role of extracellular factors in axon regeneration in the CNS: implications for therapy (Q37306814)

19 August 2017

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title

Role of extracellular factors in axon regeneration in the CNS: implications for therapy (English)

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19 August 2017

Jessica Cf Kwok

2

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author name string

Noreen M Gervasi

series ordinal

1

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PubMed ID

18947312

19 August 2017

James W Fawcett

series ordinal

3

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19 August 2017

1 November 2008

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19 August 2017

Regenerative Medicine

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19 August 2017

3

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19 August 2017

6

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19 August 2017

907-923

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The glial scar and central nervous system repair

19 August 2017

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https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Regeneration beyond the glial scar

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Reactive astrocytes protect tissue and preserve function after spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Reactive astrocytes in neural repair and protection

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Inhibition of formation of a glial barrier as a means of permitting a peripheral nerve to grow into the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Chemorepellent axon guidance molecules in spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Repair of spinal cord injuries: where are we, where are we going?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Pharmacological approaches to repair the injured spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Two membrane protein fractions from rat central myelin with inhibitory properties for neurite growth and fibroblast spreading

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Inhibitor of neurite outgrowth in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Neurite growth inhibitors restrict plasticity and functional recovery following corticospinal tract lesions.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Functional switch between motor tracts in the presence of the mAb IN-1 in the adult rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Functional recovery and neuroanatomical plasticity following middle cerebral artery occlusion and IN-1 antibody treatment in the adult rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Mechanisms of recovery of dexterity following unilateral lesion of the sensorimotor cortex in adult monkeys.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Progressive plastic changes in the hand representation of the primary motor cortex parallel incomplete recovery from a unilateral section of the corticospinal tract at cervical level in monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Expression and functional roles of neural cell surface molecules and extracellular matrix components during development and regeneration of peripheral nerves

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Oligodendrocyte-myelin glycoprotein (OMgp) is an inhibitor of neurite outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Nogo-66 receptor antagonist peptide (NEP1-40) administration promotes functional recovery and axonal growth after lateral funiculus injury in the adult rat

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

DNA vaccine against NgR promotes functional recovery after spinal cord injury in adult rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Overcoming inhibition in the damaged spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Characterization of a neurite outgrowth inhibitor expressed after CNS injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

The DSD-1 carbohydrate epitope depends on sulfation, correlates with chondroitin sulfate D motifs, and is sufficient to promote neurite outgrowth.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Chondroitin sulfate E promotes neurite outgrowth of rat embryonic day 18 hippocampal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Concentration-dependent actions of glial chondroitin sulfate on the neuritic growth of midbrain neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Chondroitinase ABC promotes sprouting of intact and injured spinal systems after spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Chondroitinase ABC promotes functional recovery after spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Neuronal activity enhances aryl hydrocarbon receptor-mediated gene expression and dioxin neurotoxicity in cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Mammalian-produced chondroitinase AC mitigates axon inhibition by chondroitin sulfate proteoglycans

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Functional axonal regeneration through astrocytic scar genetically modified to digest chondroitin sulfate proteoglycans

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Effects of inhibition of proteoglycan synthesis on the differentiation of cultured rat Schwann cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Biosynthesis of chondroitin/dermatan sulfate

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Developmental regulation of the sulfation profile of chondroitin sulfate chains in the chicken embryo brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Molecular cloning and expression of a human chondroitin synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Subcellular co-localization and potential interaction of glucuronosyltransferases with nascent proteochondroitin sulphate at Golgi sites of chondroitin synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Chondroitin sulfate synthase-2. Molecular cloning and characterization of a novel human glycosyltransferase homologous to chondroitin sulfate glucuronyltransferase, which has dual enzymatic activities

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Chondroitin sulfate synthase-3. Molecular cloning and characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Inhibiting glycosaminoglycan chain polymerization decreases the inhibitory activity of astrocyte-derived chondroitin sulfate proteoglycans

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

The transmembrane protein Off-track associates with Plexins and functions downstream of Semaphorin signaling during axon guidance

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

The organization of F-actin and microtubules in growth cones exposed to a brain-derived collapsing factor

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Peripheral nerve injury fails to induce growth of lesioned ascending dorsal column axons into spinal cord scar tissue expressing the axon repellent Semaphorin3A.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Semaphorin and neuropilin expression in motoneurons after intraspinal motoneuron axotomy.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Anti-semaphorin 3A antibodies rescue retinal ganglion cells from cell death following optic nerve axotomy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Enhanced expression of the developmentally regulated extracellular matrix molecule tenascin following adult brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Tenascin-C contains distinct adhesive, anti-adhesive, and neurite outgrowth promoting sites for neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Putative inhibitory extracellular matrix molecules at the dorsal root entry zone of the spinal cord during development and after root and sciatic nerve lesions.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Tenascin-C regulates proliferation and migration of cultured astrocytes in a scratch wound assay

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Tenascin C induces a quiescent phenotype in cultured adult human astrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Tenascin-R restricts posttraumatic remodeling of motoneuron innervation and functional recovery after spinal cord injury in adult mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Postnatal development of perineuronal nets in wild-type mice and in a mutant deficient in tenascin-R

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Tenascin-R plays a role in neuroprotection via its distinct domains that coordinate to modulate the microglia function

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Competition and cooperation between tenascin-R, lecticans and contactin 1 regulate neurite growth and morphology.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Regulation of cell survival by secreted proneurotrophins

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Clinical implications of matrix metalloproteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Elevation of matrix metalloproteinases (MMPs) in multiple sclerosis and impact of immunomodulators

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Role of matrix metalloproteinases in delayed neuronal damage after transient global cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Expression of MMP-2, MMP-9, and MMP-1 and their endogenous counterregulators TIMP-1 and TIMP-2 in postmortem brain tissue of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Elevated levels of matrix metalloproteinases-9 and -1 and of tissue inhibitors of MMPs, TIMP-1 and TIMP-2 in postmortem brain tissue of progressive supranuclear palsy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

MMP-9 deficiency affects axonal outgrowth, migration, and apoptosis in the developing cerebellum.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Myelin formation during development of the CNS is delayed in matrix metalloproteinase-9 and -12 null mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Effects of extracellular matrix-degrading proteases matrix metalloproteinases 3 and 9 on spatial learning and synaptic plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Matrix metalloproteinase-9 is required for hippocampal late-phase long-term potentiation and memory

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

In vivo roles for matrix metalloproteinase-9 in mature hippocampal synaptic physiology and plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

The extracellular protease matrix metalloproteinase-9 is activated by inhibitory avoidance learning and required for long-term memory.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Matrix metalloproteinase-2 facilitates wound healing events that promote functional recovery after spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Gelatinase B/MMP-9 and neutrophil collagenase/MMP-8 process the chemokines human GCP-2/CXCL6, ENA-78/CXCL5 and mouse GCP-2/LIX and modulate their physiological activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Membrane-type 1 matrix metalloprotease (MT1-MMP) enables invasive migration of glioma cells in central nervous system white matter

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Matrix metalloproteases and their inhibitors are produced by overlapping populations of activated astrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Zinc metalloproteinase-mediated cleavage of the human Nogo-66 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Tissue inhibitor of metalloproteinases-3 and matrix metalloproteinase-3 regulate neuronal sensitivity to doxorubicin-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Vulnerability of mouse cortical neurons to doxorubicin-induced apoptosis is strain-dependent and is correlated with mRNAs encoding Fas, Fas-Ligand, and metalloproteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Role of matrix metalloproteinases in delayed cortical responses after stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Targeting MMPs in acute and chronic neurological conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Low dose intravenous minocycline is neuroprotective after middle cerebral artery occlusion-reperfusion in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Minocycline attenuates T cell and microglia activity to impair cytokine production in T cell-microglia interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Neuroprotection by minocycline facilitates significant recovery from spinal cord injury in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Inhibiting effect of minocycline on the regeneration of peripheral nerves.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Neuroprotective role of minocycline in co-cultures of human fetal neurons and microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

T-cell- and macrophage-mediated axon damage in the absence of a CNS-specific immune response: involvement of metalloproteinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Matrix metalloproteinases and proteoglycans in axonal regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Matrix metalloproteinases and their inhibitors in human traumatic spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Enzyme treatment of spinal cord transected rats

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Suppression of fibrous scarring in spinal cord injury of rat promotes long-distance regeneration of corticospinal tract axons, rescue of primary motoneurons in somatosensory cortex and significant functional recovery

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Immunization with myelin or recombinant Nogo-66/MAG in alum promotes axon regeneration and sprouting after corticospinal tract lesions in the spinal cord

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Structural and functional recovery from early monocular deprivation in adult rats

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

PKA inhibits RhoA activation: a protection mechanism against endothelial barrier dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Regeneration of sensory axons within the injured spinal cord induced by intraganglionic cAMP elevation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

The N-terminal domain of Nogo-A inhibits cell adhesion and axonal outgrowth by an integrin-specific mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Neurite outgrowth by the alternatively spliced region of human tenascin-C is mediated by neuronal alpha7beta1 integrin.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

NT-3 promotes growth of lesioned adult rat sensory axons ascending in the dorsal columns of the spinal cord.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Ex vivo non-viral vector-mediated neurotrophin-3 gene transfer to olfactory ensheathing glia: effects on axonal regeneration and functional recovery after implantation in rats with spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Neurotrophin-3 gradients established by lentiviral gene delivery promote short-distance axonal bridging beyond cellular grafts in the injured spinal cord.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Self-assembling nanofibers inhibit glial scar formation and promote axon elongation after spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Integrin-dependent cell behavior on ECM peptide-conjugated chitosan membranes.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

In situ gelling hydrogels for conformal repair of spinal cord defects, and local delivery of BDNF after spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

An injectable, biodegradable hydrogel for trophic factor delivery enhances axonal rewiring and improves performance after spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Robust regeneration of CNS axons through a track depleted of CNS glia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Inhibiting cell proliferation during formation of the glial scar: effects on axon regeneration in the CNS.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Spinal cord injury: time to move?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Epidermal immunization by a needle-free powder delivery technology: Immunogenicity of influenza vaccine and protection in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

Purification and characterization of fetal bovine serum beta-N-acetyl-D-galactosaminyltransferase and beta-D-glucuronyltransferase involved in chondroitin sulfate biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460751.3.6.907

21 January 2018

Identifiers

DOI

10.2217/17460751.3.6.907

1 reference

19 August 2017

1 reference

PubMed ID

18947312