Study protocol for a multicentre randomised controlled trial: Safety, Tolerability, efficacy and quality of life Of a human recombinant alkaline Phosphatase in patients with sepsis-associated Acute Kidney Injury (STOP-AKI). (Q37312601)

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scientific article published on 27 September 2016

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English	Study protocol for a multicentre randomised controlled trial: Safety, Tolerability, efficacy and quality of life Of a human recombinant alkaline Phosphatase in patients with sepsis-associated Acute Kidney Injury (STOP-AKI).	scientific article published on 27 September 2016

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scholarly article

1 reference

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24 March 2020

Study protocol for a multicentre randomised controlled trial: Safety, Tolerability, efficacy and quality of life Of a human recombinant alkaline Phosphatase in patients with sepsis-associated Acute Kidney Injury (STOP-AKI) (English)

1 reference

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24 March 2020

multicenter clinical trial

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quality of life

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based on heuristic

inferred from title

acute kidney injury

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based on heuristic

inferred from title

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based on heuristic

inferred from title

Patrick T Murray

3

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24 March 2020

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object named as

John A Kellum

1 reference

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24 March 2020

Michael Joannidis

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object named as

Michael Joannidis

1 reference

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author name string

Esther Peters

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Ravindra L Mehta

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Jürgen Hummel

4

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24 March 2020

Jacques Arend

7

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Peter Pickkers

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publication date

27 September 2016

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1 reference

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6

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24 March 2020

e012371

1 reference

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24 March 2020

Pharmacokinetic Modeling and Dose Selection in a Randomized, Double-Blind, Placebo-Controlled Trial of a Human Recombinant Alkaline Phosphatase in Healthy Volunteers

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Alkaline phosphatase protects against renal inflammation through dephosphorylation of lipopolysaccharide and adenosine triphosphate.

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Catalytic signature of a heat-stable, chimeric human alkaline phosphatase with therapeutic potential.

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Alkaline phosphatase: a possible treatment for sepsis-associated acute kidney injury in critically ill patients

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Acute kidney injury: an increasing global concern

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Four hour creatinine clearance is better than plasma creatinine for monitoring renal function in critically ill patients

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Alkaline phosphatase for treatment of sepsis-induced acute kidney injury: a prospective randomized double-blind placebo-controlled trial

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Lipopolysaccharide directly alters renal tubule transport through distinct TLR4-dependent pathways in basolateral and apical membranes

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6 September 2017

Alkaline Phosphatases : Structure, substrate specificity and functional relatedness to other members of a large superfamily of enzymes

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Alkaline phosphatases reduce toxicity of lipopolysaccharides in vivo and in vitro through dephosphorylation

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Sepsis-related acute kidney injury: a protective effect of drotrecogin alpha (activated) treatment?

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Effect of the intensity of continuous renal replacement therapy in patients with sepsis and acute kidney injury: a single-center randomized clinical trial

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Minimum urine collection periods for accurate determination of creatinine clearance in critically ill patients

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Acute kidney injury

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Identifiers

10.1136/BMJOPEN-2016-012371

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