Mutation-specific potency and efficacy of cystic fibrosis transmembrane conductance regulator chloride channel potentiators. (Q37312856)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19491324%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

title

Mutation-specific potency and efficacy of cystic fibrosis transmembrane conductance regulator chloride channel potentiators (English)

1 reference

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29 January 2020

main subject

cystic fibrosis

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transmembrane protein

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author

Nicoletta Pedemonte

4

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29 January 2020

Pascale Fanen

8

1 reference

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29 January 2020

Luis Galietta

9

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29 January 2020

3

Emanuela Caci

1 reference

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29 January 2020

7

Olga Zegarra-Moran

1 reference

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29 January 2020

1

Antonella Caputo

1 reference

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29 January 2020

author name string

Alexandre Hinzpeter

2

1 reference

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29 January 2020

Nicole Arous

5

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29 January 2020

Marco Di Duca

6

1 reference

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29 January 2020

language of work or name

English

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publication date

2 June 2009

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19491324%20AND%20SRC:MED&resulttype=core&format=json

Journal of Pharmacology and Experimental Therapeutics

29 January 2020

published in

1 reference

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29 January 2020

volume

330

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29 January 2020

issue

3

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29 January 2020

page(s)

783-791

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Chloride channels as drug targets

29 January 2020

cites work

1 reference

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Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function

6 September 2017

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G551D and G1349D, two CF-associated mutations in the signature sequences of CFTR, exhibit distinct gating defects

6 September 2017

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6 September 2017

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6 September 2017

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Correction of G551D-CFTR transport defect in epithelial monolayers by genistein but not by CPX or MPB-07.

6 September 2017

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6 September 2017

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Green fluorescent protein-based halide indicators with improved chloride and iodide affinities

6 September 2017

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Novel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compounds

6 September 2017

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A common mechanism for cystic fibrosis transmembrane conductance regulator protein activation by genistein and benzimidazolone analogs

6 September 2017

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Regulation of CFTR Cl- channel gating by ATP binding and hydrolysis

6 September 2017

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The first-nucleotide binding domain of the cystic-fibrosis transmembrane conductance regulator is important for inhibition of the epithelial Na+ channel.

6 September 2017

1 reference

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Structure and function of the CFTR chloride channel

6 September 2017

1 reference

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Maturation and function of cystic fibrosis transmembrane conductance regulator variants bearing mutations in putative nucleotide-binding domains 1 and 2

6 September 2017

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Multiple membrane-cytoplasmic domain contacts in the cystic fibrosis transmembrane conductance regulator (CFTR) mediate regulation of channel gating

6 September 2017

1 reference

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14 September 2017

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A heteromeric complex of the two nucleotide binding domains of cystic fibrosis transmembrane conductance regulator (CFTR) mediates ATPase activity

14 September 2017

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14 September 2017

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14 September 2017

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28 September 2017

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26 June 2018

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2 September 2018

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2 September 2018

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2 September 2018

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Defective function of the cystic fibrosis-causing missense mutation G551D is recovered by genistein

2 September 2018

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Characterization of mutations located in exon 18 of the CFTR gene.

2 September 2018

1 reference

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Disease-Associated Mutations in Cytoplasmic Loops 1 and 2 of Cystic Fibrosis Transmembrane Conductance Regulator Impede Processing or Opening of the Channel†

2 September 2018

1 reference

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Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation

3 December 2018

1 reference

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The I148T CFTR allele occurs on multiple haplotypes: a complex allele is associated with cystic fibrosis

3 December 2018

1 reference

12 December 2020

Genotype-phenotype correlation and frequency of the 3199del6 cystic fibrosis mutation among I148T carriers: results from a collaborative study

1 reference

12 December 2020

CFTR: mechanism of anion conduction

1 reference

12 December 2020

Functional analysis of mutations in the putative binding site for cystic fibrosis transmembrane conductance regulator potentiators. Interaction between activation and inhibition

1 reference

12 December 2020

Properties of CFTR activated by the xanthine derivative X-33 in human airway Calu-3 cells

1 reference

12 December 2020

Identifiers

DOI

10.1124/JPET.109.154146

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19491324%20AND%20SRC:MED&resulttype=core&format=json

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29 January 2020

Fatcat ID

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24 November 2022

mapped directly with Wikidata item

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19491324%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

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