The ADAMs: signalling scissors in the tumour microenvironment (Q37324256)

19 August 2017

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title

The ADAMs: signalling scissors in the tumour microenvironment (English)

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19 August 2017

Gillian Murphy

1

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19 August 2017

language of work or name

English

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publication date

13 November 2008

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19 August 2017

published in

Nature Reviews Cancer

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19 August 2017

volume

8

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19 August 2017

issue

12

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19 August 2017

page(s)

929-941

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Matrix Metalloproteinase Inhibitors and Cancer--Trials and Tribulations

19 August 2017

cites work

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Emerging roles of proteases in tumour suppression

31 March 2020

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Structural features of a superfamily of zinc-endopeptidases: the metzincins

31 March 2020

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Future challenges facing the development of specific active-site-directed synthetic inhibitors of MMPs

31 March 2020

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Cytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3.

31 March 2020

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Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain

31 March 2020

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Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor

31 March 2020

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Structural considerations of the snake venom metalloproteinases, key members of the M12 reprolysin family of metalloproteinases.

31 March 2020

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Emerging roles of ADAM and ADAMTS metalloproteinases in cancer.

31 March 2020

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Chromosomal assignment of four testis-expressed mouse genes from a new family of transmembrane proteins (ADAMs) involved in cell-cell adhesion and fusion

31 March 2020

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ADAMs in cancer cell proliferation and progression.

31 March 2020

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Emerging roles for ectodomain shedding in the regulation of inflammatory responses

31 March 2020

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The genetics of asthma: ADAM33 as an example of a susceptibility gene

31 March 2020

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Part-time alpha-secretases: the functional biology of ADAM 9, 10 and 17.

31 March 2020

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A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo

31 March 2020

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The splicing and fate of ADAM33 transcripts in primary human airways fibroblasts

31 March 2020

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A secreted form of ADAM9 promotes carcinoma invasion through tumor-stromal interactions

31 March 2020

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Up-regulated expression of ADAM17 in human colon carcinoma: co-expression with EGFR in neoplastic and endothelial cells

31 March 2020

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ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression.

31 March 2020

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ADAM15 disintegrin is associated with aggressive prostate and breast cancer disease

31 March 2020

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Expression of the disintegrin metalloprotease, ADAM-10, in prostate cancer and its regulation by dihydrotestosterone, insulin-like growth factor I, and epidermal growth factor in the prostate cancer cell model LNCaP.

31 March 2020

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Nuclear translocation of ADAM-10 contributes to the pathogenesis and progression of human prostate cancer

31 March 2020

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Critical function for ADAM9 in mouse prostate cancer

31 March 2020

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ADAM-17 predicts adverse outcome in patients with breast cancer

31 March 2020

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TACE is required for the activation of the EGFR by TGF-alpha in tumors

31 March 2020

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Expression of ADAM-9 mRNA and protein in human breast cancer

31 March 2020

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The consensus coding sequences of human breast and colorectal cancers

31 March 2020

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Breast cancer-associated mutations in metalloprotease disintegrin ADAM12 interfere with the intracellular trafficking and processing of the protein

31 March 2020

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EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

31 March 2020

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ADAMs: key components in EGFR signalling and development

31 March 2020

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Evaluation of the contribution of different ADAMs to tumor necrosis factor alpha (TNFalpha) shedding and of the function of the TNFalpha ectodomain in ensuring selective stimulated shedding by the TNFalpha convertase (TACE/ADAM17).

31 March 2020

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TNF-alpha in promotion and progression of cancer

31 March 2020

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ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death.

31 March 2020

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The ADAM metalloproteinases

31 March 2020

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Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer

31 March 2020

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(Make) stick and cut loose--disintegrin metalloproteases in development and disease

31 March 2020

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ADAMs: modulators of cell–cell and cell–matrix interactions

31 March 2020

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Breaking up the tie: disintegrin-like metalloproteinases as regulators of cell migration in inflammation and invasion.

31 March 2020

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ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation.

31 March 2020

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Tumor-associated MICA is shed by ADAM proteases

31 March 2020

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ADAM10-mediated release of complement membrane cofactor protein during apoptosis of epithelial cells

31 March 2020

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ERBB receptors and cancer: the complexity of targeted inhibitors

31 March 2020

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ADAM proteases, ErbB pathways and cancer

31 March 2020

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ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and prognosis

31 March 2020

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Selective inhibition of ADAM metalloproteases as a novel approach for modulating ErbB pathways in cancer.

31 March 2020

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Targeting TACE-dependent EGFR ligand shedding in breast cancer

31 March 2020

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Selective inhibition of ADAM metalloproteases blocks HER-2 extracellular domain (ECD) cleavage and potentiates the anti-tumor effects of trastuzumab

31 March 2020

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Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx

31 March 2020

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Sequential processing of the transmembrane chemokines CX3CL1 and CXCL16 by alpha- and gamma-secretases

31 March 2020

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The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone

31 March 2020

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Presenilin: running with scissors in the membrane

31 March 2020

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ErbB receptors: new insights on mechanisms and biology

31 March 2020

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An intermediary role of proHB-EGF shedding in growth factor-induced c-Myc gene expression

31 March 2020

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Notch signaling, gamma-secretase inhibitors, and cancer therapy

31 March 2020

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Clipping, shedding and RIPping keep immunity on cue.

31 March 2020

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Intracellular maturation and localization of the tumour necrosis factor alpha convertase (TACE)

31 March 2020

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Stimulation-induced down-regulation of tumor necrosis factor-alpha converting enzyme

31 March 2020

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Biochemical properties and functions of membrane-anchored metalloprotease-disintegrin proteins (ADAMs)

31 March 2020

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Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1

31 March 2020

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Targeting the protein kinase C family: are we there yet?

31 March 2020

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Protein tyrosine phosphatases: from genes, to function, to disease

31 March 2020

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Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca(2+) influx and PKC activation

31 March 2020

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ERK-mediated phosphorylation of Thr735 in TNFalpha-converting enzyme and its potential role in TACE protein trafficking

31 March 2020

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Integrin trafficking and its role in cancer metastasis

31 March 2020

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The ADAMs family of metalloproteases: multidomain proteins with multiple functions

31 March 2020

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A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.

31 March 2020

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ADAM10 mediates ectodomain shedding of the betacellulin precursor activated by p-aminophenylmercuric acetate and extracellular calcium influx

31 March 2020

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A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44

31 March 2020

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A distinct ER/IC gamma-secretase competes with the proteasome for cleavage of APP

31 March 2020

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Roles of Meltrin beta /ADAM19 in the processing of neuregulin

31 March 2020

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Meltrin beta (ADAM19) mediates ectodomain shedding of Neuregulin beta1 in the Golgi apparatus: fluorescence correlation spectroscopic observation of the dynamics of ectodomain shedding in living cells

31 March 2020

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Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)

31 March 2020

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A basolateral sorting signal directs ADAM10 to adherens junctions and is required for its function in cell migration

31 March 2020

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L-selectin: mechanisms and physiological significance of ectodomain cleavage.

31 March 2020

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Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands.

31 March 2020

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Identification of ARTS-1 as a novel TNFR1-binding protein that promotes TNFR1 ectodomain shedding

31 March 2020

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Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor-alpha-converting enzyme

31 March 2020

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The shedding of membrane-anchored heparin-binding epidermal-like growth factor is regulated by the Raf/mitogen-activated protein kinase cascade and by cell adhesion and spreading

31 March 2020

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The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors

31 March 2020

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Profiling of the Tetraspanin Web of Human Colon Cancer Cells

31 March 2020

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EphB/EphrinB receptors and Wnt signaling in colorectal cancer

31 March 2020

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Eph/ephrin signalling and function in oncogenesis: lessons from embryonic development.

31 March 2020

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Cell-cell signaling via Eph receptors and ephrins

31 March 2020

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Notch signalling: a simple pathway becomes complex

31 March 2020

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ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors

31 March 2020

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GPCR-induced migration of breast carcinoma cells depends on both EGFR signal transactivation and EGFR-independent pathways.

31 March 2020

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Estrogen signaling via a linear pathway involving insulin-like growth factor I receptor, matrix metalloproteinases, and epidermal growth factor receptor to activate mitogen-activated protein kinase in MCF-7 breast cancer cells

31 March 2020

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Wnt1 and Wnt5a induce cyclin D1 expression through ErbB1 transactivation in HC11 mammary epithelial cells.

31 March 2020

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Progesterone receptors upregulate Wnt-1 to induce epidermal growth factor receptor transactivation and c-Src-dependent sustained activation of Erk1/2 mitogen-activated protein kinase in breast cancer cells

31 March 2020

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Chemotactic agents induce IL-6Ralpha shedding from polymorphonuclear cells: involvement of a metalloproteinase of the TNF-alpha-converting enzyme (TACE) type

31 March 2020

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RECK modulates Notch signaling during cortical neurogenesis by regulating ADAM10 activity

31 March 2020

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Metalloproteinase inhibitors: biological actions and therapeutic opportunities.

31 March 2020

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Structure and function of matrix metalloproteinases and TIMPs

31 March 2020

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Tissue inhibitor of metalloproteinase 3 regulates TNF-dependent systemic inflammation.

31 March 2020

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TIMP-3 deficiency in the host, but not in the tumor, enhances tumor growth and angiogenesis

31 March 2020

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Tissue inhibitor of metalloproteinases-3 promoter methylation is an independent prognostic factor for bladder cancer.

31 March 2020

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Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling.

31 March 2020

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Drug insight: tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis

31 March 2020

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Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer

31 March 2020

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ADAM10 as a target for anti-cancer therapy

31 March 2020

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Inflammation and breast cancer: metalloproteinases as common effectors of inflammation and extracellular matrix breakdown in breast cancer

31 March 2020

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Engineering N-terminal domain of tissue inhibitor of metalloproteinase (TIMP)-3 to be a better inhibitor against tumour necrosis factor-alpha-converting enzyme

31 March 2020

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ADAM22, expressed in normal brain but not in high-grade gliomas, inhibits cellular proliferation via the disintegrin domain.

31 March 2020

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ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation

31 March 2020

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TACE and other ADAM proteases as targets for drug discovery

31 March 2020

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TACE-dependent EGF receptor activation in angiotensin-II-induced kidney disease

31 March 2020

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A closer look at alpha-secretase

31 March 2020

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P2Y2 nucleotide receptors enhance alpha-secretase-dependent amyloid precursor protein processing.

31 March 2020

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Amino-terminal TACE prodomain attenuates TNFR2 cleavage independently of the cysteine switch.

31 March 2020

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Crystal structures of VAP1 reveal ADAMs' MDC domain architecture and its unique C-shaped scaffold

31 March 2020

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Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans

31 March 2020

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Function of the cysteine-rich domain of the haemorrhagic metalloproteinase atrolysin A: targeting adhesion proteins collagen I and von Willebrand factor.

31 March 2020

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The cysteine-rich domain regulates ADAM protease function in vivo

31 March 2020

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Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme

31 March 2020

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The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells

31 March 2020

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ADAM binding protein Eve-1 is required for ectodomain shedding of epidermal growth factor receptor ligands

31 March 2020

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Metalloproteinase disintegrins ADAM8 and ADAM19 are highly regulated in human primary brain tumors and their expression levels and activities are associated with invasiveness

31 March 2020

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ADAM8 as a novel serological and histochemical marker for lung cancer

31 March 2020

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ADAM8 expression is associated with increased invasiveness and reduced patient survival in pancreatic cancer

31 March 2020

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Overexpression of ADAM9 in non-small cell lung cancer correlates with brain metastasis

31 March 2020

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ADAM9 expression in pancreatic cancer is associated with tumour type and is a prognostic factor in ductal adenocarcinoma

31 March 2020

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L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers

31 March 2020

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ADAMs (a disintegrin and metalloproteinase) messenger RNA expression in Helicobacter pylori-infected, normal, and neoplastic gastric mucosa

31 March 2020

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L1 expression as a predictor of progression and survival in patients with uterine and ovarian carcinomas.

31 March 2020

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ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage

31 March 2020

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ADAM12 is selectively overexpressed in human glioblastomas and is associated with glioblastoma cell proliferation and shedding of heparin-binding epidermal growth factor

31 March 2020

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ADAM12 in human liver cancers: TGF-β-regulated expression in stellate cells is associated with matrix remodeling

31 March 2020

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Increased expression of ADAM family members in human breast cancer and breast cancer cell lines

31 March 2020

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Expression of ADAM15 in lung carcinomas.

31 March 2020

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Inhibition of ADAM17 reduces hypoxia-induced brain tumor cell invasiveness

31 March 2020

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ADAM28 is overexpressed in human breast carcinomas: implications for carcinoma cell proliferation through cleavage of insulin-like growth factor binding protein-3

31 March 2020

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ADAM28 is overexpressed in human non-small cell lung carcinomas and correlates with cell proliferation and lymph node metastasis

31 March 2020

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Identifiers

DOI

10.1038/NRC2459

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Dimensions Publication ID

19 August 2017

1004907132

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