Notch signalling: a simple pathway becomes complex (Q29555851)

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29 December 2019

review article

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title

Notch signalling: a simple pathway becomes complex (English)

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author name string

Bray SJ

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publication date

1 September 2006

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Nature Reviews Molecular Cell Biology

29 December 2019

published in

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volume

7

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issue

9

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page(s)

678-689

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Notch signaling: cell fate control and signal integration in development

29 December 2019

cites work

1 reference

Regulation of notch signaling activity

25 April 2017

1 reference

Notch signaling: from the outside in

25 April 2017

1 reference

Notch promotes neural lineage entry by pluripotent embryonic stem cells

25 April 2017

1 reference

Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta

25 April 2017

1 reference

Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta

25 April 2017

1 reference

Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila

25 April 2017

1 reference

Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish development

25 April 2017

1 reference

Interaction of the MAGUK family member Acvrinp1 and the cytoplasmic domain of the Notch ligand Delta1

25 April 2017

1 reference

Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear

25 April 2017

1 reference

Protein O -fucosyltransferase 1 is an essential component of Notch signaling pathways

25 April 2017

1 reference

Fringe is a glycosyltransferase that modifies Notch

25 April 2017

1 reference

Deregulated NOTCH signaling in acute T-cell lymphoblastic leukemia/lymphoma: new insights, questions, and opportunities

25 April 2017

1 reference

Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase

25 April 2017

1 reference

Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes

25 April 2017

1 reference

MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors

25 April 2017

1 reference

Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

25 April 2017

1 reference

SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function

25 April 2017

1 reference

p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro

25 April 2017

1 reference

Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex

25 April 2017

1 reference

Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor

25 April 2017

1 reference

SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

25 April 2017

1 reference

The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

25 April 2017

1 reference

RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes

25 April 2017

1 reference

CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex

25 April 2017

1 reference

Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5

25 April 2017

1 reference

Instability of Hes7 protein is crucial for the somite segmentation clock

25 April 2017

1 reference

Identification of Drosophila MicroRNA targets

25 April 2017

1 reference

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

25 April 2017

1 reference

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

25 April 2017

1 reference

The role of Notch in tumorigenesis: oncogene or tumour suppressor?

25 April 2017

1 reference

Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling

31 March 2020

1 reference

Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

31 March 2020

1 reference

Notch signalling in vertebrate neural development

31 March 2020

1 reference

Notch signals control the fate of immature progenitor cells in the intestine

31 March 2020

1 reference

The adult Drosophila posterior midgut is maintained by pluripotent stem cells.

31 March 2020

1 reference

Evidence that stem cells reside in the adult Drosophila midgut epithelium.

31 March 2020

1 reference

Why is delta endocytosis required for effective activation of notch?

31 March 2020

1 reference

The roles of receptor and ligand endocytosis in regulating Notch signaling

31 March 2020

1 reference

neuralized Encodes a peripheral membrane protein involved in delta signaling and endocytosis.

31 March 2020

1 reference

Xenopus neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates Notch signaling.

31 March 2020

1 reference

The interplay between DSL proteins and ubiquitin ligases in Notch signaling.

31 March 2020

1 reference

The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta

31 March 2020

1 reference

Distinct roles for Mind bomb, Neuralized and Epsin in mediating DSL endocytosis and signaling in Drosophila.

31 March 2020

1 reference

Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch.

31 March 2020

1 reference

Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells.

31 March 2020

1 reference

Drosophila melanogaster auxilin regulates the internalization of Delta to control activity of the Notch signaling pathway

31 March 2020

1 reference

A secreted Delta1-Fc fusion protein functions both as an activator and inhibitor of Notch1 signaling

31 March 2020

1 reference

Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors.

31 March 2020

1 reference

Asymmetric Rab 11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous system

31 March 2020

1 reference

The lateral signal for LIN-12/Notch in C. elegans vulval development comprises redundant secreted and transmembrane DSL proteins

31 March 2020

1 reference

Epsin potentiates Notch pathway activity in Drosophila and C. elegans

31 March 2020

1 reference

Bearded family members inhibit Neuralized-mediated endocytosis and signaling activity of Delta in Drosophila.

31 March 2020

1 reference

Dorsal-ventral pattern of Delta trafficking is established by a Snail-Tom-Neuralized pathway.

31 March 2020

1 reference

Echinoid synergizes with the Notch signaling pathway in Drosophila mesothorax bristle patterning.

31 March 2020

1 reference

Delta-promoted filopodia mediate long-range lateral inhibition in Drosophila.

31 March 2020

1 reference

The C-terminal PDZ-ligand of JAGGED1 is essential for cellular transformation

31 March 2020

1 reference

Complex proteolytic processing acts on Delta, a transmembrane ligand for Notch, during Drosophila development

31 March 2020

1 reference

Processing of the notch ligand delta by the metalloprotease Kuzbanian

31 March 2020

1 reference

Down-regulation of Delta by proteolytic processing

31 March 2020

1 reference

Unidirectional Notch signaling depends on continuous cleavage of Delta

31 March 2020

1 reference

Fringe, Notch, and making developmental boundaries.

31 March 2020

1 reference

Glycosylation regulates Notch signalling.

31 March 2020

1 reference

neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions

31 March 2020

1 reference

Regulation of notch signaling by o-linked fucose.

31 March 2020

1 reference

Chaperone activity of protein O-fucosyltransferase 1 promotes notch receptor folding.

31 March 2020

1 reference

Notch activity in neural cells triggered by a mutant allele with altered glycosylation.

31 March 2020

1 reference

Glycosyltransferase activity of Fringe modulates Notch-Delta interactions.

31 March 2020

1 reference

Modulation of notch-ligand binding by protein O-fucosyltransferase 1 and fringe.

31 March 2020

1 reference

An O-fucose site in the ligand binding domain inhibits Notch activation

31 March 2020

1 reference

Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1

31 March 2020

1 reference

The segmentation clock: converting embryonic time into spatial pattern

31 March 2020

1 reference

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

31 March 2020

1 reference

Notch and presenilin: a proteolytic mechanism emerges

31 March 2020

1 reference

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

31 March 2020

1 reference

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

31 March 2020

1 reference

Evidence for functional redundancy between C. elegans ADAM proteins SUP-17/Kuzbanian and ADM-4/TACE

31 March 2020

1 reference

Shedding light on ADAM metalloproteinases

31 March 2020

1 reference

Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor

31 March 2020

1 reference

Self-refinement of Notch activity through the transmembrane protein Crumbs: modulation of gamma-secretase activity

31 March 2020

1 reference

Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins

31 March 2020

1 reference

Hrs mediates downregulation of multiple signalling receptors in Drosophila

31 March 2020

1 reference

Regulation of Notch signalling by non-visual beta-arrestin

31 March 2020

1 reference

Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila

31 March 2020

1 reference

The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking

31 March 2020

1 reference

Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth

31 March 2020

1 reference

The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila

31 March 2020

1 reference

Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain

31 March 2020

1 reference

Numb inhibits membrane localization of Sanpodo, a four-pass transmembrane protein, to promote asymmetric divisions in Drosophila

31 March 2020

1 reference

Numb and alpha-Adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organs

31 March 2020

1 reference

Numb-associated kinase interacts with the phosphotyrosine binding domain of Numb and antagonizes the function of Numb in vivo

31 March 2020

1 reference

Numb proteins specify asymmetric cell fates via an endocytosis- and proteasome-independent pathway.

31 March 2020

1 reference

Protein degradation: four E3s for the notch pathway

31 March 2020

1 reference

Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans

31 March 2020

1 reference

LIN-12/Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans

31 March 2020

1 reference

Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation

31 March 2020

1 reference

Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change

31 March 2020

1 reference

Drosophila deltex mediates suppressor of Hairless-independent and late-endosomal activation of Notch signaling.

31 March 2020

1 reference

Contact-dependent inhibition of cortical neurite growth mediated by notch signaling

31 March 2020

1 reference

Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA

31 March 2020

1 reference

Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA.

31 March 2020

1 reference

Mastermind is a putative activator for Notch.

31 March 2020

1 reference

Hairless-mediated repression of notch target genes requires the combined activity of Groucho and CtBP corepressors

31 March 2020

1 reference

Transcriptional repression by suppressor of hairless involves the binding of a hairless-dCtBP complex in Drosophila.

31 March 2020

1 reference

Lateral inhibition in proneural clusters: cis-regulatory logic and default repression by Suppressor of Hairless

31 March 2020

1 reference

A histone deacetylase corepressor complex regulates the Notch signal transduction pathway

31 March 2020

1 reference

An EGFR/Ebi/Sno pathway promotes delta expression by inactivating Su(H)/SMRTER repression during inductive notch signaling.

31 March 2020

1 reference

Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless

31 March 2020

1 reference

Notch pathway: making sense of suppressor of hairless

31 March 2020

1 reference

Regulation of expression of Vg and establishment of the dorsoventral compartment boundary in the wing imaginal disc by Suppressor of Hairless

31 March 2020

1 reference

A Notch-independent function of Suppressor of Hairless during the development of the bristle sensory organ precursor cell of Drosophila

31 March 2020

1 reference

A notch-independent activity of suppressor of hairless is required for normal mechanoreceptor physiology

31 March 2020

1 reference

Transcriptional specificity of human SWI/SNF BRG1 and BRM chromatin remodeling complexes

31 March 2020

1 reference

Genetic screens for enhancers of brahma reveal functional interactions between the BRM chromatin-remodeling complex and the delta-notch signal transduction pathway in Drosophila

31 March 2020

1 reference

Nipped-A, the Tra1/TRRAP subunit of the Drosophila SAGA and Tip60 complexes, has multiple roles in Notch signaling during wing development

31 March 2020

1 reference

Bre1 is required for Notch signaling and histone modification

31 March 2020

1 reference

Chromatin regulation and sumoylation in the inhibition of Ras-induced vulval development in Caenorhabditis elegans

31 March 2020

1 reference

Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing.

31 March 2020

1 reference

A model Notch response element detects Suppressor of Hairless-dependent molecular switch.

31 March 2020

1 reference

Spatially restricted factors cooperate with notch in the regulation of Enhancer of split genes.

31 March 2020

1 reference

A DNA transcription code for cell-specific gene activation by notch signaling

31 March 2020

1 reference

Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability

31 March 2020

1 reference

The vertebrate segmentation clock

31 March 2020

1 reference

Lethal giant larvae controls the localization of notch-signaling regulators numb, neuralized, and Sanpodo in Drosophila sensory-organ precursor cells

31 March 2020

1 reference

Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAs

31 March 2020

1 reference

The REF-1 family of bHLH transcription factors pattern C. elegans embryos through Notch-dependent and Notch-independent pathways.

31 March 2020

1 reference

Unequal segregation of Neuralized biases Notch activation during asymmetric cell division

31 March 2020

1 reference

Notch activation regulates the segregation and differentiation of rhombomere boundary cells in the zebrafish hindbrain

31 March 2020

1 reference

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31 March 2020

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29 December 2019

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