Overexpression of IGF-1 in muscle attenuates disease in a mouse model of spinal and bulbar muscular atrophy (Q37328024)

19 August 2017

Overexpression of IGF-1 in muscle attenuates disease in a mouse model of spinal and bulbar muscular atrophy (English)

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19 August 2017

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7

Gen Sobue

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19 August 2017

Isabella Palazzolo

1

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19 August 2017

Conor Stack

2

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19 August 2017

Lingling Kong

3

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19 August 2017

Antonio Musaro

4

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19 August 2017

Hiroaki Adachi

5

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19 August 2017

Masahisa Katsuno

6

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19 August 2017

J Paul Taylor

8

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19 August 2017

Charlotte J Sumner

9

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19 August 2017

Kenneth H Fischbeck

10

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19 August 2017

Maria Pennuto

11

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19 August 2017

language of work or name

English

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publication date

1 August 2009

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19 August 2017

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19 August 2017

63

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3

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19 August 2017

316-328

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describes a project that uses

19 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2735765/fullTextXML

inferred from PubMed Central ID database lookup

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In vivo suppression of polyglutamine neurotoxicity by C-terminus of Hsp70-interacting protein (CHIP) supports an aggregation model of pathogenesis.

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Subcutaneous IGF-1 is not beneficial in 2-year ALS trial

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Spinal and bulbar muscular atrophy: a motoneuron or muscle disease?

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Signaling in muscle atrophy and hypertrophy

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Androgen-dependent pathology demonstrates myopathic contribution to the Kennedy disease phenotype in a mouse knock-in model

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6 September 2017

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Muscle expression of a local Igf-1 isoform protects motor neurons in an ALS mouse model

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Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase

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Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

6 September 2017

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PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?

6 September 2017

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Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor

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Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle

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Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone

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6 September 2017

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AML1 is expressed in skeletal muscle and is regulated by innervation

6 September 2017

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Aggregation and proteasome: the case of elongated polyglutamine aggregation in spinal and bulbar muscular atrophy.

6 September 2017

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The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors

14 September 2017

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14 September 2017

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28 September 2017

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Nerve sprouting in innervated adult skeletal muscle induced by exposure to elevated levels of insulin-like growth factors

28 September 2017

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Soluble androgen receptor oligomers underlie pathology in a mouse model of spinobulbar muscular atrophy

2 September 2018

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Comparison of gene expression of 2-mo denervated, 2-mo stimulated-denervated, and control rat skeletal muscles

2 September 2018

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Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model.

2 September 2018

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Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy

2 September 2018

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Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

2 September 2018

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The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

2 September 2018

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Members of several gene families influence survival of rat motoneurons in vitro and in vivo.

2 September 2018

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Akt blocks ligand binding and protects against expanded polyglutamine androgen receptor toxicity

2 September 2018

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Expression of X-linked bulbospinal muscular atrophy (Kennedy disease) in two homozygous women

3 December 2018

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12 December 2020

Insulin-like growth factors: putative muscle-derived trophic agents that promote motoneuron survival

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12 December 2020

Myogenic vector expression of insulin-like growth factor I stimulates muscle cell differentiation and myofiber hypertrophy in transgenic mice

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12 December 2020

Effect of recombinant human insulin-like growth factor-I on progression of ALS. A placebo-controlled study. The North America ALS/IGF-I Study Group

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12 December 2020

A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis. European ALS/IGF-I Study Group

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12 December 2020

Localized treatment with a novel FDA-approved proteasome inhibitor blocks the degradation of dystrophin and dystrophin-associated proteins in mdx mice

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12 December 2020

10.1016/J.NEURON.2009.07.019

Identifiers

DOI

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19 August 2017

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19 August 2017

PubMed publication ID

19679072

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