Hepatic basolateral efflux contributes significantly to rosuvastatin disposition I: characterization of basolateral versus biliary clearance using a novel protocol in sandwich-cultured hepatocytes (Q37331801)

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scientific article published on 10 September 2013

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English	Hepatic basolateral efflux contributes significantly to rosuvastatin disposition I: characterization of basolateral versus biliary clearance using a novel protocol in sandwich-cultured hepatocytes	scientific article published on 10 September 2013

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20 February 2020

Hepatic basolateral efflux contributes significantly to rosuvastatin disposition I: characterization of basolateral versus biliary clearance using a novel protocol in sandwich-cultured hepatocytes (English)

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20 February 2020

Kim L.R. Brouwer

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20 February 2020

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Nathan D Pfeifer

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20 February 2020

Kyunghee Yang

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20 February 2020

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10 September 2013

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20 February 2020

Journal of Pharmacology and Experimental Therapeutics

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20 February 2020

347

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20 February 2020

3

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20 February 2020

727-736

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20 February 2020

Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data

1 reference

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6 September 2017

Elevated hepatic multidrug resistance-associated protein 3/ATP-binding cassette subfamily C 3 expression in human obstructive cholestasis is mediated through tumor necrosis factor alpha and c-Jun NH2-terminal kinase/stress-activated protein kinase-s

1 reference

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6 September 2017

Effect of culture time on the basal expression levels of drug transporters in sandwich-cultured primary rat hepatocytes

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6 September 2017

Evaluation of (99m)technetium-mebrofenin and (99m)technetium-sestamibi as specific probes for hepatic transport protein function in rat and human hepatocytes

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6 September 2017

Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity.

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6 September 2017

Hepatobiliary disposition of troglitazone and metabolites in rat and human sandwich-cultured hepatocytes: use of Monte Carlo simulations to assess the impact of changes in biliary excretion on troglitazone sulfate accumulation.

1 reference

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6 September 2017

Use of tc-99m mebrofenin as a clinical probe to assess altered hepatobiliary transport: integration of in vitro, pharmacokinetic modeling, and simulation studies

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6 September 2017

Rosuvastatin pharmacokinetics in heart transplant recipients administered an antirejection regimen including cyclosporine

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6 September 2017

Statin-associated myopathy

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6 September 2017

Tissue distribution and induction of human multidrug resistant protein 3

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6 September 2017

Mechanisms of bile secretion: insights from the isolated rat hepatocyte couplet

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6 September 2017

Absolute quantification and differential expression of drug transporters, cytochrome P450 enzymes, and UDP-glucuronosyltransferases in cultured primary human hepatocytes

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14 September 2017

ATP-dependent transport of rosuvastatin in membrane vesicles expressing breast cancer resistance protein

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14 September 2017

The effect of gemfibrozil on the pharmacokinetics of rosuvastatin

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14 September 2017

Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3).

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28 September 2017

Understanding the interplay of drug transporters involved in the disposition of rosuvastatin in the isolated perfused rat liver using a physiologically-based pharmacokinetic model.

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26 June 2018

Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin

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26 June 2018

In vitro biliary clearance of angiotensin II receptor blockers and 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in sandwich-cultured rat hepatocytes: comparison with in vivo biliary clearance.

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26 June 2018

Drug/Drug interaction between lopinavir/ritonavir and rosuvastatin in healthy volunteers

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26 June 2018

Lack of effect of ketoconazole on the pharmacokinetics of rosuvastatin in healthy subjects

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26 June 2018

Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities.

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2 September 2018

Improved extrapolation of hepatobiliary clearance from in vitro sandwich cultured rat hepatocytes through absolute quantification of hepatobiliary transporters

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836307

2 September 2018

ABCG2 polymorphism is associated with the low-density lipoprotein cholesterol response to rosuvastatin

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2 September 2018

Biliary efflux transporters involved in the clearance of rosuvastatin in sandwich culture of primary rat hepatocytes

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836307

2 September 2018

ABCG2 polymorphism markedly affects the pharmacokinetics of atorvastatin and rosuvastatin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836307

2 September 2018

LC-MS/MS mediated absolute quantification and comparison of bile salt export pump and breast cancer resistance protein in livers and hepatocytes across species.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836307

2 September 2018

Absolute difference of hepatobiliary transporter multidrug resistance-associated protein (MRP2/Mrp2) in liver tissues and isolated hepatocytes from rat, dog, monkey, and human.

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2 September 2018

Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3836307

2 September 2018

Characterization of transport protein expression in multidrug resistance-associated protein (Mrp) 2-deficient rats.

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2 September 2018

Multiple transport systems mediate the hepatic uptake and biliary excretion of the metabolically stable opioid peptide [D-penicillamine2,5]enkephalin

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2 September 2018

Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat.

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2 September 2018

Absolute oral bioavailability of rosuvastatin in healthy white adult male volunteers

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2 September 2018

Uptake of rosuvastatin by isolated rat hepatocytes: comparison with pravastatin

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2 September 2018

Pharmacokinetics and pharmacodynamics of rosuvastatin in subjects with hepatic impairment

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2 September 2018

Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4).

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2 September 2018

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2 September 2018

Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and atpase activities by interaction with dietary flavonoids

1 reference

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2 September 2018

Use of Ca2+ modulation to evaluate biliary excretion in sandwich-cultured rat hepatocytes.

1 reference

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2 September 2018

Carbon monoxide as a regulator of bile canalicular contractility in cultured rat hepatocytes

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2 September 2018

Role of BCRP 421C>A polymorphism on rosuvastatin pharmacokinetics in healthy Chinese males

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3 December 2018

Statin-associated myopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/24023367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variability in human hepatic MRP4 expression: influence of cholestasis and genotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/24023367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Culture period-dependent changes in the uptake of transporter substrates in sandwich-cultured rat and human hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24023367

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/JPET.113.207472

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24023367%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

PMC publication ID

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Europe PubMed Central

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20 February 2020

PubMed publication ID

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Europe PubMed Central

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20 February 2020

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