Brain cancer stem cells display preferential sensitivity to Akt inhibition (Q37335643)

19 August 2017

Brain cancer stem cells display preferential sensitivity to Akt inhibition (English)

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19 August 2017

neoplastic stem cells

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Anita B Hjelmeland

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Roger E McLendon

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Jeremy N Rich

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19 August 2017

Christine E Eyler

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19 August 2017

Wen-Chi Foo

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19 August 2017

Katherine M LaFiura

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18 September 2008

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3027-3036

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describes a project that uses

19 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2739007/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Glioma formation, cancer stem cells, and akt signaling

1 reference

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Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer

6 September 2017

1 reference

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PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo

6 September 2017

1 reference

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Mechanisms of disease: the PI3K-Akt-PTEN signaling node--an intercept point for the control of angiogenesis in brain tumors

6 September 2017

1 reference

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PI3K/PTEN signaling in tumorigenesis and angiogenesis

6 September 2017

1 reference

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Diagnosis and treatment of high-grade astrocytoma

6 September 2017

1 reference

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CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells

6 September 2017

1 reference

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A perivascular niche for brain tumor stem cells

6 September 2017

1 reference

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Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma

6 September 2017

1 reference

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Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

6 September 2017

1 reference

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Cancer stem cells: models and concepts

6 September 2017

1 reference

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Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor

6 September 2017

1 reference

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2739007

PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry

6 September 2017

1 reference

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Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas

6 September 2017

1 reference

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Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition.

6 September 2017

1 reference

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

6 September 2017

1 reference

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Identification of human brain tumour initiating cells

6 September 2017

1 reference

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Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma

6 September 2017

1 reference

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Therapeutic implications of cancer stem cells.

6 September 2017

1 reference

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Cancerous stem cells can arise from pediatric brain tumors

6 September 2017

1 reference

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Identification of a cancer stem cell in human brain tumors

6 September 2017

1 reference

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Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4.

6 September 2017

1 reference

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CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway.

14 September 2017

1 reference

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Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy

14 September 2017

1 reference

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The combination of novel low molecular weight inhibitors of RAF (LBT613) and target of rapamycin (RAD001) decreases glioma proliferation and invasion

14 September 2017

1 reference

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Phosphatidylinositol ether lipid analogues that inhibit AKT also independently activate the stress kinase, p38alpha, through MKK3/6-independent and -dependent mechanisms.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2739007

Targeting of CD44 eradicates human acute myeloid leukemic stem cells

14 September 2017

1 reference

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Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice

14 September 2017

1 reference

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CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles.

28 September 2017

1 reference

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Cotreatment with a novel phosphoinositide analogue inhibitor and carmustine enhances chemotherapeutic efficacy by attenuating AKT activity in gliomas.

2 September 2018

1 reference

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Activation of Akt and Erk pathways in medulloblastoma.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2739007

Regulation of Akt/PKB Ser473 phosphorylation

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2739007

Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2739007

Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo.

2 September 2018

1 reference

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Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2739007

The Akt/mammalian target of rapamycin signal transduction pathway is activated in high-risk myelodysplastic syndromes and influences cell survival and proliferation

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2739007

10.1634/STEMCELLS.2007-1073

20 October 2018

Identifiers

DOI

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19 August 2017

1 reference

19 August 2017

1 reference