Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53. (Q37339040)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19494119%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

title

Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53 (English)

1 reference

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30 January 2020

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4

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30 January 2020

author name string

Stephen M Sykes

1

1 reference

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30 January 2020

Timothy J Stanek

2

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30 January 2020

Amanda Frank

3

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30 January 2020

Steven B McMahon

5

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30 January 2020

language of work or name

English

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publication date

3 June 2009

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Journal of Biological Chemistry

30 January 2020

published in

1 reference

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30 January 2020

volume

284

1 reference

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30 January 2020

page(s)

20197-20205

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30 January 2020

issue

30

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Targeting p53 to mitochondria for cancer therapy

30 January 2020

cites work

1 reference

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Regulation of programmed cell death by the p53 pathway.

6 September 2017

1 reference

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Monoubiquitylation promotes mitochondrial p53 translocation

6 September 2017

1 reference

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Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate.

6 September 2017

1 reference

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Dissecting p53-dependent apoptosis.

6 September 2017

1 reference

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Ubiquitination of p53 at multiple sites in the DNA-binding domain

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740446

PUMA couples the nuclear and cytoplasmic proapoptotic function of p53

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740446

Stress-induced p53 runs a transcription-independent death program

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740446

In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation

6 September 2017

1 reference

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Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

6 September 2017

1 reference

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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740446

p53's believe it or not: lessons on transcription-independent death

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740446

p53 has a direct apoptogenic role at the mitochondria

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740446

Live or let die: the cell's response to p53

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740446

WAF1, a potential mediator of p53 tumor suppression

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740446

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740446

Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740446

Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740446

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740446

Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740446

Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740446

Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740446

Acetylation of the p53 DNA-binding domain regulates apoptosis induction

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740446

Structural basis of DNA recognition by p53 tetramers.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740446

The post-translational phosphorylation and acetylation modification profile is not the determining factor in targeting endogenous stress-induced p53 to mitochondria

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740446

Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740446

p53 mutations in benign prostatic hyperplasia.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2740446

p53 null mutations undetected by immunohistochemical staining predict a poor outcome with early-stage non-small cell lung carcinomas

2 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19494119

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M109.026096

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19494119%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19494119%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

1 reference